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University of Groningen Application of poly(trimethylene carbonate) and calcium phosphate composite biomaterials in oral and maxillofacial surgery Zeng, Ni

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Application of poly(trimethylene carbonate) and calcium phosphate composite biomaterials in

oral and maxillofacial surgery

Zeng, Ni

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2017

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Zeng, N. (2017). Application of poly(trimethylene carbonate) and calcium phosphate composite biomaterials in oral and maxillofacial surgery. Rijksuniversiteit Groningen.

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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A P P L I C AT I O N O F P O LY ( T R I M E T HYL E N E C A R B O N AT E )

A N D C A LC I U M P H O S P H AT E CO M P O S I T E B I O M AT E R I A L S

I N O R A L A N D M AX I L LO FAC I A L S U R G E RY

Ni Zeng

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ISBN (printed version) 978-90-367-9408-4 ISBN (electronic version) 978-90-367-9407-7

Cover design, layout and printing: Off Page, Amsterdam

Universitair Medisch Centrum Groningen, Rijksuniversiteit Groningen, Groningen, Nederland Copyright © 2016 by Ni Zeng

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A P P L I C AT I O N O F P O LY ( T R I M E T HYL E N E C A R B O N AT E )

A N D C A LC I U M P H O S P H AT E CO M P O S I T E B I O M AT E R I A L S

I N O R A L A N D M AX I L LO FAC I A L S U R G E RY

PhD thesis 

to obtain the degree of PhD at the University of Groningen

on the authority of

the Rector Magnificus Prof. E. Sterken and in accordance with the decision by the College of Deans. This thesis will be defended in public on  Monday 16 January 2017 at 12.45 hours

by  Ni Zeng  born on 21 April 1986

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CO - S U P E R V I S O R

Dr. R. Kuijer 

A S S E S S M E N T CO M M I T T E E

Prof. R.A. Bank

Prof. G.J. Meijer Prof. E.A.J.M. Schulten

PA R A N I M F E N

Simon Robert Hemelaar Arden Leander van Arnhem

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TA B L E O F CO N T E N TS

Chapter 1 General introduction and aim of the thesis 7 Chapter 2 Barrier Membranes for Guided Bone Regeneration in Implant Surgery: 17

a review

Chapter 3 Histological Evaluation of Degradable Guided Bone Regeneration 39 Membranes Prepared from Poly(trimethylene carbonate)

and Biphasic calcium phosphate composites

Chapter 4 Evaluation of Novel Resorbable Membranes for Bone Augmentation 51 in A Rat Model

Chapter 5 Poly(trimethylene carbonate)-based Composite Materials 65 for Reconstruction of Critical-sized Cranial Bone Defects in Sheep

Chapter 6 Evaluation of Osteoinductivity of Different Calcium Phosphate 87 and PTMC-Calcium Phosphate Composite Biomaterials in a Sheep Model

Chapter 7 General Discussion 109

Appendix Summary 119

Samenvatting 122

摘要 125

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