University of Groningen
Supercharged proteins and polypeptides for advanced materials in chemistry and biology
Ma, Chao
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Publication date: 2019
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Ma, C. (2019). Supercharged proteins and polypeptides for advanced materials in chemistry and biology. University of Groningen.
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Propositions
Accompanying the thesisSupercharged Proteins and Polypeptides for
Advanced Materials in Chemistry and Biology
Chao Ma
1. Elastin-based supercharged unstructured proteins (SUPs) can be complexed with oppositely charged surfactants to induce liquid formation.
2. Supercharging proteins bestows materials with new properties such as prevention of ice formation when applied on surfaces (Chapter 2).
3. SUPs fused to fluorescent proteins can function as active components in fluorescence assays without exhibiting a well-defined binding site for an analyte (Chapter 3).
4. The combination of a fluorescent protein with SUPs can be exploited in a diagnostic context to authenticate whiskeys (Chapter 3).
5. Taking advantage of electrostatic interactions, GFP-SUP works as a ‘glue’ for cocrystal construction with CCMV capsids. Such assemblies could serve as a protective shell for cargo proteins and might facilitate the structure determination of biomacromolecules by X-ray analysis in the future if guest proteins are incorporated in an ordered manner (Chapter 4).
6. SUP fusions self-assemble into hierarchical architectures when combined with β-sheet forming motifs in an alternating fashion (Chapter 5).
7．“苟日新，日日新，又日新”出自《大学》。(If you can improve yourself in a day, do so each day, forever building on improvement. From the <Great Learning>, ~ 5th century BC, recorded by disciples of Confucius)
