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The handle http://hdl.handle.net/1887/137968 holds various files of this Leiden University dissertation.
Author: Hamming, A.M.
Title: Spreading depolarizations, migraine and ischemia: A detrimental triangle in subarachnoid hemorrhage and ischemic stroke?
Issue Date: 2020-11-12
Acknowledgements
159
Acknowledgements
Completing this thesis was a ten year journey. The limited space of these
acknowledgements isn’t enough to thank all the people who helped me navigate through it and illustrates the journey.
This voyage started when Marieke Wermer had just started working in Leiden and got a PhD student, because there was some funding-without-a-plan. After extensively exploring unsuitable topics such as endothelial progenitor cells, we finally settled for relating stroke to a theme that was already big in Leiden: migraine. Michel Ferrari was kind enough to adopt us and the role of spreading depolarizations in stroke turned out to be a fascinating topic. But the hypotheses we generated required animal research. And if you say animal stroke research in the Netherlands, you say Rick Dijkhuizen, who runs a lab that’s both very professional and a joy to work in. While all three of my thesis advisors taught me a lot in their own way, one person deserves special mention: Arn van den Maagdenberg who advised us a lot.
Umesh, what a great chemistry we had, both professionally and socially. I hope to see you many times in the future. I can’t mention all the colleagues I’ve met along this journey, but I’d like to thank Gerard van Vliet, Ann Stowe and Annette van der Toorn for the enjoyable collaboration. Inge Mulder and Wouter Mol, we complemented each other, which made it a strong collaboration.
The reflection skills I learnt in occupational health care were a great compass while completing this thesis. If only I had learnt them at the start! Special thanks to Bedrijfsartsen5, Team Europoort, Ger Kaldenborg and Jos van Rooyen.
My friends keep me afloat; Acoutes (Bram, Hessel, Joost, Paul, Roger), Round Table 154, Jottum sailing team, Barbara, Barkhad, Coen, Dewi, Jeroen, Lien, Marko, Micha, Paula, Rianne, Robin, Ruth, Thomas, Ton, Thorvald, Wendy, Feuten and all those I can’t mention here.
Tim, the journey of a PhD thesis ends for me too now, but I hope to embark on many more trips with you.
Family is my buoy. Thanks to my parents and parents in law for looking after the kids.
Rosa, a boat stands firmer with two anchors. Mirjam, we both enjoy sailing. The waters are sometimes rough and I’m glad to share my life boat with you. Fenna, Maarten: land ho!
List of publications
163
List of publications
Het blijft kwakzalverij (3). Hamming AM. Medisch Contact. 2006 Sep; 61(36) 1422-1422 Spreading depolarization modulating drugs and delayed cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage. Mulder IA, Hamming AM, Gathier CS, van den Bergh WM, Dankbaar, JW, Hoff, RG, Ferrari, MD, Rinkel, GJE, Algra, A, Wermer, MJH. Cerebrovasc Dis 2014;37, Supplement: 1: B2117, 539-539
The Dutch String-of-Pearls Stroke Study: protocol of a large prospective multicenter genetic cohort study. Nederkoorn PJ, van Dijk EJ, Koudstaal PJ, Luijckx GJ, van Oostenbrugge RJ, Visser MC, Wermer MJ, Ruigrok YM, Algra A, Kappelle LJ; Dutch String-of-Pearls Stroke Study- Group. Int J Stroke. 2015 Jan;10(1):120-122.
Measurement of Distinctive Features of Cortical Spreading Depolarizations with Different MRI Contrasts. Umesh Rudrapatna S, Hamming AM, Wermer MJH, van der Toorn A, Dijkhuizen RM.
NMR Biomed 2015 May; 28(5):591-600.
Spreading depolarization-modulating drugs and delayed cerebral ischemia in patients with subarachnoid haemorrhage. Mulder IA, Hamming AM, Gathier CS, van den Bergh WM, vandertop WP, Verbaan D, Ferrari MD, Rinkel GJE, Algra A, Wermer MJH. Cephalalgia 2015 May; vol. 35, 6_suppl, 178-178
Spreading depolarizations increase delayed brain injury in a rat model of subarachnoid
hemorrhage. Hamming, AM, Wermer MJH, Rudrapatna U, Lanier C, van Os HJ, van den Bergh W, Ferrari MD, van der Toorn A, van den Maagdenberg, AMJM, Stowe AM. Dijkhuizen RM. Int j Stroke 2015 May; 10, Supplement 2, 194-194
Migrainde and anatomical variations in the ricle of Willis in patients with ischemic stroke.
Hamming AM, van Walderveen MAA, Mulder IA, van der Schaaf IC, Kapelle LJ, Velthuis BK, Ferrari MD, Visser MC, Schonewille W, Algra A. and Wermer MJH. European Stroke Journal 2016 May; vol. 1, 1_suppl, 3-612, 190-191
Valproate reduces brain injury by spreading depolarizations in a rat model of subarachnoid haemorrhage. Hamming AM, van der Toorn A, Rudrapatna SU, Ma L, van Os H, Ferrari MD, van den Maagdenberg A, Stowe A, Dijkhuizen R, Wermer MJH. European Stroke Journal 2016 May;
vol. 1, 1_suppl, 3-612, 395-396
Addendum List of publications
Een arbeidsarts voor zzp’ers zij aan zij met de huisarts. Hamming A, thanks to De Bruin TAPM, Van Rhenen W. Medisch Contact 75(41), Oktober 8 2020: 18-19.
Cognitieve beperkingen. Handvatten om persoonlijk functioneren in kaart te brengen. Hamming AM, Brand T. Tijdschrift voor Bedrijfs- en Verzekeringsgeneeskunde 2020; 28(10): 43-46.
Spreading depolarization-modulating drugs and delayed cerebral ischemia in patients with subarachnoid haemorrhage. Hamming AM, Mulder IA, Gathier CS, van den Bergh WM, Dankbaar JW, Hoff RG, vandertop WP, Verbaan D, Ferrari MD, Rinkel GJE, Algra A, Wermer MJH. J Neurol Sci 2016 Jul 15; 366:224-228.
Valproate reduces brain injury by spreading depolarizations in a rat model of subarachnoid haemorrhage. Hamming AM, van der Toorn A, Rudrapatna SU, Ma L, van Os H, Ferrari MD, van den Maagdenberg A, Stowe A, Dijkhuizen R, Wermer MJH. J Cereb Blood Flow Metab 2016 Jun; 36, Supplement 1, 350-351
Spreading depolarizations increase delayed brain injury in a rat model of subarachnoid haemorrhage. Hamming AM, Wermer MJH, Umesh Rudrapatna S, Lanier C, van Os HJ, van den Bergh WM, Ferrari MD, van der Toorn A, van den Maagdenberg AM, Stowe AM, Dijkhuizen RM. J Cereb Blood Flow Metab 2016 Jul; 36(7):1224-1231.
Landelijk Opleidingsplan Bedrijfsarts. Coffeng P, Smits P, Hoekstra H, Bastiaanssen M, Jurgens E, Thunnissen MJ, Sijderius R, Vissers P, de Jong P, Hamming AM, Guijt M, Yntema C.
Nederlandse Vereniging voor Arbeids- en Bedrijfsgeneeskunde (NVAB), 2016 Nov.
Valproate reduces brain injury by spreading depolarizations in a rat model of subarachnoid haemorrhage. Hamming AM, van der Toorn A, Rudrapatna US, Ma L, van Os HJ, Ferrari MD, van den Maagdenberg AM, van Zwet E, Poinsatte K, Stowe AM, Dijkhuizen RM, Wermer MJH.
Stroke 2017 Feb; 48(2):452-458.
Wat een bedrijfsarts voor je kan betekenen. Hamming AM. Werk en veiligheid. 2017 Mrt.
Published online (https://www.werkenveiligheid.nl/preventie/de-praktijk/wat-een-bedrijfsarts- voor-je-kan-betekenen)
Bedrijfsarts zoekt contact met preventiemedewerker. Hamming AM. Werk en veiligheid. 2017 Nov. Published online (http://www.werkenveiligheid.nl/preventie/rollen-en-verantwoordelijkheden/
bedrijfsarts-zoekt-contact-met-preventiemedewerker)
Ontdek net als Arend het vak van bedrijfsarts. Hamming AM, Hoedemakers K, Arbo Unie.
YouTube 2018 Aug (youtu.be/J7NFohLGIGc)
Curriculum Vitae
Curriculum vitae
Arend (Maarten) Hamming was born August 20, 1979 in Amsterdam. After graduating from secondary school at the Hervormd Lyceum Zuid with an extra subject and all eights or higher, he studied psychology and medicine at Maastricht University. During a side job in home care, he became aware of the impact of health on daily life. During another side job as statistics tutor, he developed an interest for scientific research and for education. After that he worked as neurology resident at the Amphia hospital in Breda (ANIOS) and the Leiden University Medical Center (AIOS). There he was involved in the implementation of a biobank and electronic health record and he performed the research of this thesis.
He attended several conferences and courses, such as laboratory animal science (Artikel 9) and the Invivo NMR course.
In 2015 he switched to occupational medicine. The hospital approach, focussed on diagnoses and organs were too limited for him. Sending patients back to the general practitioner with a note saying
“there is no neurological explanation for the symptoms” was not in line with his desire to help people get healthier, which often requires a broader perspective on prevention, the causes of symptoms and a positive health approach to the consequenses of disease. In 2020 he finished his four-year training as an occupational health physician, a job which he enjoys greatly. He likes to advise individuals about health and prevention and finds partnership in discussing these themes with companies. He has a guest appointment at the Polikliniek Mens en Arbeid of Amsterdam University Medical Center. He also has a passion for teaching new colleagues the ins and outs of occupational health care.
He is married to Mirjam and has two children: Fenna and Maarten. In his spare time he likes sea/match sailing, vegetarian cooking, running and ballroom and latin dancing.
