Podoplanin and the posterior heart field : epicardial-myocardial interaction
Mahtab, E.A.F.
Citation
Mahtab, E. A. F. (2008, October 21). Podoplanin and the posterior heart field : epicardial- myocardial interaction. Retrieved from https://hdl.handle.net/1887/13214
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/13214
Note: To cite this publication please use the final published version (if applicable).
[Samenvatting]
198
ﺏﻮﻴﺗ ﻪﮐ ﯽﺗﺍﺮﺠﺣﺯﺍ ﺐﻠﻗ یﺍﺪﺘﺑﺍ یﺍﺪﺘﺑﺍ ﻪﺣﺎﺳﺯﺍ
ﺐﻠﻗ
‘primary heart field’
ﻞﻴﮑﺸﺗ ،ﺪﻧﺮﻴﮕﻴﻣ ﺎﺸﻨﻣﺮﺳ
ﻣ ﺩﺩﺮﮕﻴ . ﻦﻳﺍﺯﺍ ﺖﻳﺎﻬﻧﺭﺩ ﺏﻮﻴﺗ
ﻃﺎﺒﺗﺭﺍ ﮏﻳ ﯽ یﺍﺭﺍﺩ ﻪﮐ ﻝﺎﻌﻓ ﯽﺒﻠﻗ ﺠﻣ
ﺎ ،ﻦﻄﺑ ﻭﺩ ،ﺰﻴﻠﻫﺩ ﻭﺩ ،یﺩﻭﺭﻭ یﺭ
ﺠﻣ ﺎ ﻭ ﯽﺟﻭﺮﺧ یﺭ ﻃﺎﺒﺗﺭﺍ ﻢﺘﺴﻴﺳ ﮏﻳ
ﯽ ﺪﺷﺎﺒﻴﻣ
، ﺩﺩﺮﮕﻴﻣ ﻞﻴﮑﺸﺗ .
ﺖﻤﺴﻗ ﮏﻳ ﻭ ﺐﻠﻗﺯﺍ ﻩﺪﻤﻋ
ﻢﺘﺴﻴﺳ
ﺩﻮﺷ ﻪﺘﺧﺎﺳ ﺪﻳﺎﺑﺯﻮﻨﻫ ﺶﻠﻣﺎﮑﺗ ﻥﺎﻳﺮﺟﺭﺩ ﻥﺁ ﯽﻃﺎﺒﺗﺭﺍ .
ﯽﺗﺍﺮﺠﺣﺯﺍ ﺐﻠﻗ ﻞﻣﺎﮑﺗ ﻪﻴﻘﺑ ﺐﻠﻗ ﯽﻣﻭﺩ ﻪﺣﺎﺳﺯﺍ ﻪﮐ
‘second heart field’
ﺩﻮﺸﻴﻣ ﻪﺘﺧﺎﺳ ،ﺪﻧﺮﻴﮕﻴﻣ ُﺎﺸﻨﻣ .
ﺎﻣ ﻦﺘﻣ ﻦﻳﺍﺭﺩ ﻪﺣﺎﺳ ﺕﺍﺮﺠﺣ ﻥﺩﻮﻤﻧ ﻪﻓﺎﺿﺍ
ﺐﻠﻗ ﯽﻣﻭﺩ
‘splanchnic mesoderm’
ﻪﺑ ﺵﻮﻣ ﮏﻳ ﺐﻠﻗ یﺪﻳﺭﻭ ﺐﻄﻗ ﺍﺭ
ﻡﻁﺍﻝﻉﻩ ﻢﻴﻳﺎﻤﻨﻴﻣ . ﻦﻳﺪﺑ
ﻦﻴﺟﺯﺍ ﺎﻣﺭﻮﻈﻨﻣ podoplanin
ﺍﺪﻳﺪﺟ ﻪﮐ "
ﻢﻳﺩﻮﻤﻧ ﻩﺩﺎﻔﺘﺳﺍ ﻩﺪﺷ ﻪﺘﺧﺎﻨﺷ .
ﻦﻴﺟﺮﻫﺎﻈﺗ ﻉﻮﻧ ﺎﻣ ﻖﻴﻘﺤﺗ ﻦﻳﺍﺭﺩ
podoplanin ﻥﺁ ﻁﺎﺒﺗﺭﺍﻭ
ﻞﻣﺎﮑﺗ ﺎﺑ ﮏﻳژﻮﻟﻮﻳﺮﺒﻣﺍ
ﺐﻠﻗ ﻪﻌﻟﺎﻄﻣ ﯽﻣﻭﺩ ﻪﺣﺎﺳﺯﺍ ﻢﻳﺩﻮﻤﻧ
. ﻥﺁ ﻩﻭﻼﻋ ﻪﺑ
ﺯﺍ ﺵﻮﻣ ﺐﻠﻗ یﺪﻳﺭﻭ ﺐﻄﻗ ﮏﻳژﻮﻟﻮﻳﺮﺒﻣﺍ ﻞﻣﺎﮑﺗ podoplanin
ﺩﺮﮔ ﯽﺑﺎﻳﺯﺭﺍ ﻞﻣﺎﮑﺗ ﺎﺑ ﻭ ﻩﺪﻳ
ﯽﺸﺣﻭ یﺎﻫ ﺵﻮﻣ ﺐﻠﻗ ﮏﻳژﻮﻟﻮﻳﺮﺒﻣﺍ (wild type)
ﺕﻮﮑﻧﻭ (knockout) ﺪﻳﺩﺮﮔ ﻪﺴﻳﺎﻘﻣ
.
ﻮﻟﻮﻳﺮﺒﻣﺍ ﻞﻣﺎﮑﺗﺯﺍ ﻪﺻﻼﺧ ﻝﻭﺍ ﻞﺼﻓ ﺪﺷﺎﺒﻴﻣ ﻥﺁﺯﺎﻏﺁ ﻪﻠﺣﺮﻣﺭﺩ ﺐﻠﻗ ﮏﻳژ
. ﺐﻠﻗ یﺍﺪﺘﺑﺍ ﺏﻮﻴﺗ یﺎﻫ ﻪﻳﻻ ﺯﺍ
ﯽﺒﻧﺎﺟ ﺖﻤﺴﻗ ﮏﻴﻨﺟﻮﻳﺩﺭﺎﮐ ﻡﺭﺩﻭﺰﻴﻣ
ﺮﻴﮕﻴﻣ ًﺎﺸﻨﻣﺮﺳ ﻧ
ﺪ . ﺍ ﻪﺣﺎﺳ ﺎﻫ ﻪﻳﻻ ﻦﻳﺍ یﺍﺪﺘﺑ
ﺐﻠﻗ
‘primary(first)
heart field’
ﺪﻧﺯﺎﺴﻴﻣ ﺍﺭ .
ﺐﻠﻗ ﺏﻮﻴﺗ )
ﭗﭼ ﻦﻄﺑﻭ ﻦﻄﺑﻭﺰﻴﻠﻫﺩ ﻦﻴﺑ ﻝﺎﻧﺎﮐ ،ﺰﻴﻠﻫﺩ ﻭﺩ ﺯﺍ ﺖﻤﺴﻗ ﮏﻳ ﻪﮐ
ﺩﺮﻴﮕﻴﻣﺮﺑﺭﺩ ﺍﺭ ﺐﻠﻗ (
ﺪﺷﺎﺒﻴﻣ یﺪﻳﺭﻭ ﺐﻄﻗ ﮏﻳ ﻭ ﯽﻧﺎﻳﺮﺷ ﺐﻄﻗ ﮏﻳ یﺍﺭﺍﺩ .
ﺕﺍﺮﺠﺣ ﻥﺪﺷ ﻪﻓﺎﺿﺍ ﺎﺑ
ﺐﻠﻗ ﻡﻭﺩ ﻪﺣﺎﺳ ﺯﺍ ﻝﻭﺍ ﻪﺣﺎﺳ ﺕﺍﺮﺠﺣ ﺪﻨﻧﺎﻣ ﻪﮐ
splanchnic mesoderm
ًﺎﺸﻨﻣﺮﺳ ﻞﻣﺎﮑﺗ ،ﺪﻧﺮﻴﮕﻴﻣ
ﺍﺪﻴﭘ ﻪﻣﺍﺩﺍ ﺐﻠﻗ ﺏﻮﻴﺗ ﺪﻳﺎﻤﻨﻴﻣ
. ﺖﻳﺎﻬﻧﺭﺩ ﻦﻄﺑﻭﺩﻭﺰﻴﻠﻫﺩ ﻭﺩ یﺍﺭﺍﺩ ﻪﮐ ﻞﻣﺎﮐ ﺐﻠﻗ ﮏﻳ ﻩﺩﻮﺑ
ﮏﻳ ﻂﺳﻮﺗﻭ
ﺩﺩﺮﮕﻴﻣ ﻞﻴﮑﺸﺗ ،ﺪﻨﺷﺎﺒﻴﻣ ﺍﺪﺟ ﻢﻫﺯﺍﺭﺍﺪﺟ .
ﺯﺍ ﻪﮐ ﯽﺗﺍﺮﺠﺣ ﻥﺪﺷ ﻪﻓﺎﺿﺍ ﺎﺑ ﺐﻠﻗ ﯽﻧﺎﻳﺮﺷ ﺐﻄﻗ ﻥﺎﻨﭽﻤﻫ ﻪﺣﺎﺳ
ﺐﻠﻗ ﻡﻭﺩ ﻪﺣﺎﺳﻭ ﯽﻣﺍﺪﻗ
‘secondary-‘
ﻭ
‘anterior heart field’
ًﺎﺸﻨﻣﺮﺳ ﻪﻣﺍﺩﺍ ﺩﻮﺧ ﻞﻣﺎﮑﺗ ﻪﺑ ،ﺪﻧﺮﻴﮕﻴﻣ
ﺪﻫﺪﻴﻣ . ﺐﻠﻗ ﯽﻔﻠﺧ ﻪﺣﺎﺳ ﺕﺍﺮﺠﺣ ﮏﻤﮐ ﺎﺑ ،ﺪﺷﺎﺒﻴﻣ ﺎﻣ ﻪﺟﻮﺗ ﺩﺭﻮﻣ ﻪﺣﺎﺳ ﻥﺎﻨﭽﻤﻫ ﻪﮐ ،ﺐﻠﻗ یﺪﻳﺭﻭ ﺐﻄﻗ
‘posterior heart field’
ﺪﻫﺪﻴﻣ ﻪﻣﺍﺩﺍ ﺩﻮﺧ ﻞﻣﺎﮑﺗ ﻪﺑ .
ﺐﻠﻗ ﯽﻔﻠﺧ ﻪﺣﺎﺳ ﻡﻭﺩ ﻞﺼﻓﺭﺩ
، ﺐﻠﻗ ﻡﻭﺩ ﻪﺣﺎﺳﺯﺍ ﯽﺘﻤﺴﻗ ﻪﮐ ،ﺪﺷﺎﺒﻴﻣ
ﯽﻓﺮﻌﻣ ﺩﺩﺮﮕﻴﻣ . ﻥﺎﻨﭽﻤﻫ ﻪﻓﺎﺿﺍ
ﺩﺩﺮﮕﻴﻣ ﻪﻌﻟﺎﻄﻣ یﺪﻳﺭﻭ ﺐﻄﻗ ﻪﺑ ﻪﺣﺎﺳ ﻦﻳﺍ ﺕﺍﺮﺠﺣ ﻥﺪﺷ .
ﯽﻔﻠﺧ ﻪﺣﺎﺳ ﺞﺴﻧ ﻥﺪﺷ ﻪﻓﺎﺿﺍ ﻝﻮﺤﺗ ﺕﺭﻮﺼﺑ
ﻢﻴﺸﻧﺍﺰﻴﻣ ﻪﺑ ﻞﻴﺘﻴﭘﺍ
‘epitheel-mesenchym transformation’
ﻪﺘﻓﺮﮔ ﺕﺭﻮﺻ ﻪﺳﻭﺮﭘ ﻦﻳﺍﺭﺩﻭ
‘coelomic epithelium’
ﺩﺮﻴﮕﻴﻣ ﻢﻬﺳ .
ﻪﻓﺎﺿﺍﺯﺍ ﺪﻌﺑ ﯽﻔﻠﺧ ﻪﺣﺎﺳ ﺕﺍﺮﺠﺣ ﻪﮐ ﻢﻴﻳﺎﻤﻧ ﺖﺑﺎﺛ ﻢﻴﺘﺴﻧﺍﻮﺗ ﺎﻣ
ﺶﺨﺑ ﻭﺩ ﻪﺑ یﺪﻳﺭﻭ ﺐﻄﻗ ﻪﺑ ﻥﺪﺷ ﺪﻨﻧﺍﻮﺘﻴﻣ
ﺪﻧﻮﺷ ﻢﻴﺴﻘﺗ .
1 ﻥﺪﺷ ﻪﻓﺎﺿﺍ . ﺩﺭﺎﮑﻴﭘﺍ ﻭﺮﭘ ﻥﺎﮔﺭﺍ ﻞﻣﺎﺷ ،یﺍﺪﺘﺑﺍ ﻪﻠﺣﺮﻣ ﺭﺩ ﻢﻴﺸﻧﺍﺰﻴﻣ
‘proepicardial organ’
ﻥﺁ ﺕﺎﻘﺘﺸﻣ ﻭ .
2 ،ﺩﺭﺎﮐﻮﻴﻣ ﻥﺪﺷ ﻪﻓﺎﺿﺍ . ﻪﻠﻤﺟﺯﺍ
ﻡﺯﻮﻨﻳﻭ ﺱﻮﻨﻴﺳ ﺩﺭﺎﮐﻮﻴﻣ
‘sinus venosus’
ﺯﺍ یﺎﻫ ﺶﺨﺑﻭ
ﯽﻃﺎﺒﺗﺭﺍ ﻢﺘﺴﻴﺳ ﺐﻠﻗ
.
،ﺩﺭﺎﮑﻴﭘﺍﻭﺮﭘ ﻥﺎﮔﺭﺍ ﻞﻣﺎﮑﺗﺭﺩ ﯽﻤﻴﺸﻧﺍﺮﭘ ﺕﺍﺮﺠﺣ ﻪﻋﻮﻤﺠﻣ ﻪﻧﻮﮕﭼ ﻪﮐ ﻢﻳﺩﺍﺩ ﻥﺎﺸﻧ ﺎﻣ ﻡﻮﺳ ﻞﺼﻓﺭﺩ
،ﺪﻧﺮﻴﮕﻴﻣ ًﺎﺸﻨﻣ ﺮﺳ ﺩﺭﺎﮑﻴﭘﺍ ﺯﺍ ﻪﮐ ﯽﺗﺍﺮﺠﺣ ﻭ ﺩﺭﺎﮑﻴﭘﺍ یﺯﺎﺑ ﻝﻭﺭ
ﺪﻳﺎﻤﻨﻴﻣ . ﻪﮐ ﯽﺗﺍﺮﺠﺣ ًﺎﺸﻨﻣ ﺩﺭﺎﮐ ﯽﭘﺍ ﺯﺍ
ﺪﻧﺮﻴﮕﻴﻣ
‘epicardium derived cells, EPDC’s’
ﻣ ﻞﻣﺎﮑﺗﺭﺩ ﺍﺭ ﻩﺪﻤﻋ ﻝﻭﺭ ،ﺎﻫ ﺖﺳﻼﺑﻭﺮﺒﻴﻓ ،ﺩﺭﺎﮐﻮﻴ
ﺪﻧﺭﺍﺩ ﺞﻨﮐﺭﻮﭘ ﻑﺎﻴﻟﺍ ﺹﻮﺼﺨﺑ ﺐﻠﻗ ﯽﻃﺎﺒﺗﺭﺍ ﻢﺘﺴﻴﺳ ﻭ ﺩﺭﺎﮐﻭﺪﻧﺍ ،ﺐﻠﻗ ﻦﻴﻳﺍﺮﺷ .
ﻥﺎﮔﺭﺍ ﻞﻣﺭﺎﻧ ﺮﻴﻏ ﻞﻣﺎﮑﺗ
ﻞﻴﮑﺸﺗ ﺭﺩ ﺺﻗﺎﻨﺗ ،ﺩﺭﺎﮑﻴﭘﺍﻭﺮﭘ EPDC’s
ﺩﺭﺎﮐﻮﻴﻣﻭ ﺩﺭﺎﮑﻴﭘﺍ ﻦﻴﺑ ﻞﻤﻌﻟﺍ ﺲﮑﻋﺭﺩ ﺵﻮﺸﺗ ﺎﻳ ﻭ ﻦﻴﻨﺟﺭﺩ
یﺎﻫ ﺵﻮﻣ ﻦﻴﻨﻠﭘﻭﺩﻮﭘ ﻦﻴﺟ ﻪﮐ
ﺮﻫﺎﻈﺘﻣ ،ﺪﻨﺘﺷﺍﺪﻧ ﺍﺭ ﺪﻳﺩﺮﮔ
. ﻻﺎﺑ ﺕﺎﺷﻮﺸﺗ ﻞﻴﻠﻟﺩ ﻥﺪﺸﻧ ﻪﻓﺎﺿﺍ
ﻢﺸﻧﺍﺰﻴﻣ ﻪﺣﺎﺳ
ﺎﻫ ﺵﻮﻣ ﻦﻳﺍ ﻦﻴﺑﺭﺩ ﯽﺒﻠﻗ ﻢﻴﺧﻭ یﺎﻫ ﯽﻟﺎﻣﻮﻧﺍ ﻪﺑﺮﺠﻨﻣ ﺕﺎﺷﻮﺸﺗ ﻦﻳﺍ ﻭ ﻩﺩﻮﺑ یﺪﻳﺭﻭ ﺐﻄﻗ ﻪﺑ ﺐﻠﻗ ﯽﻔﻠﺧ ﺪﻳﺩﺮﮔ . ﻦﻴﺟ ﻦﺸﻴﺗﻮﻴﻣ ﻪﮑﻳﺎﻬﺷﻮﻣ ﻦﻴﺑﺭﺩ ﻥﺎﻨﭽﻤﻫ ﺪﻨﺘﺷﺍﺩ ﺍﺭ ﻦﻴﻨﻠﭘﻭﺩﻮﭘ
ﻭ ﺎﻫﺰﻴﻠﻫﺩ ﺩﺭﺎﮐﻮﻴﻣ یﺯﻼﭘﻮﭙﻴﻫ
ﺐﻠﻗ یﺎﻫ ﻦﻄﺑ ﺍﺪﺟ ﻞﮑﺸﺗ ﻡﺪﻋ ﺎﺑ ﺍﺮﻤﻫ
ﺪﻴﺳﺭ ﻩﺪﻫﺎﺸﻣ ﻪﺑ ﻦﻄﺑ ﻭﺩ ﻭ ﺰﻴﻠﻫﺩ ﻭﺩ ﻦﻴﺑ ﺭ .
ﯽﻄﺳﻭ ﻪﻳﻻ ﻩﻭﻼﻋﺮﺑ
ﯽﺒﻠﻗ ﻪﻴﻋﻭﺍ
‘coronary artery’
،ﺩﺩﺮﮕﻴﻣ ﻞﻴﮑﺸﺗ ﻢﺸﻟ ﻪﻠﻀﻋﺯﺍ ﻪﮐ ﻞﻣﺎﮑﺗﻭ ﻩﺩﻮﺑ کﺯﺎﻧ
ﮏﻴﺘﺳﻼﭘﻮﭙﻴﻫ
ﺖﺷﺍﺩ .
199
ﺐﻠﻗ ﯽﻔﻠﺧ ﻪﺣﺎﺳ ﺶﻘﻧ ﻪﺑ ﺩﺭﺍﺩ ﺹﺎﺼﺘﺧﺍ ﻡﺭﺎﻬﭼ ﻞﺼﻓ ﻪﻴﺣﺎﻧ ﺩﺭﺎﮐﻮﻴﻣ ﻪﮐ یﺪﻳﺭﻭ ﺐﻄﻗﺭﺩ
sinus
venosus ﺩﺯﺎﺴﻴﻣ ﺍﺭ
. ﻳ ﺪﺷﺎﺒﻴﻣ ﻢﻴﻬﺳ ﺐﻠﻗ ﯽﻃﺎﺒﺗﺭﺍ ﻢﺘﺴﻴﺳ ﻦﺘﺧﺎﺳ ﺭﺩ ﻥﺁ ﺯﺍ ﺖﻤﺴﻗ ﮏ .
ﺩﺭﺎﮐﻮﻴﻣ ﻪﻴﺣﺎﻧ
sinus venosus ﯽﻔﻠﺧﺭﺍﺪﺟ ،ﺰﻴﻠﻫﺩﻭﺩ ﻦﻴﺑ یﺍﺪﺘﺑﺍﺭﺍﺪﺟ ،یﺪﻳﺭﻭ یﺎﻫ ﻝﺍﻭ ،ﻝﺎﻳﺮﺗﺍﻮﻨﻴﺳ ﻩﺮﮔ ﻩﺪﻧﺮﻴﮔﺮﺑﺭﺩ
ﻭ ﺐﻠﻗ ﭗﭼ ﺰﻴﻠﻫﺩ ﺍﻭﺎﮐ ﺎﻨﻳﻭ یﺎﻫ ﺪﻳﺭﻭ ﻭ ﺎﻫ ﺶﺷ یﺎﻫ ﺪﻳﺭﻭ ﻑﺍﺮﻃﺍ ﺩﺭﺎﮐﻮﻴﻣ
’venae cava’
ﺪﺷﺎﺒﻴﻣ .
ﻞﻣﺎﮑﺗ ﺎﻣ ﻥﺎﻨﭽﻤﻫ ﺭﺩ ﻪﮐ ﻢﻳﺩﺮﮐ ﻪﻌﻟﺎﻄﻣ ﺍﺭ ﯽﭙﭼ ﻝﺎﻳﺮﺗﺍﻮﻨﻴﺳ ﻩﺮﮔ ﮏﻳ
% ﺪﻧﺎﻤﻴﻣ ﯽﻗﺎﺑ ﺕﺎﻌﻗﺍﻭ 10 .
ﺮﺛﺍﺭﺩ
ﻪﻴﺣﺎﻧ ﻦﻴﻧﻼﭘﻭﺩﻮﭘ ﻦﻴﺟ ﻦﺸﻴﺗﻮﻴﻣ sinus venosus
ﺩﻮﺑ ﻩﺪﻧﺎﻣ ﯽﻗﺎﺑ ﮏﻴﺘﺳﻼﭘﻮﭙﻴﻫ ﻉﻮﻤﺠﻣﺭﺩ .
ﻩﺮﮔ
ﻮﮐ یﺪﻳﺭﻭ یﺎﻫ ﻝﺍﻭ ،ﻩﺪﻧﺎﻣ ﮏﭼﻮﮐ ﻝﺎﻳﺮﺗﺍﻮﻨﻴﺳ ﺶﺷ یﺎﻫ ﺪﻳﺭﻭﺭﺍﺪﺟ، ﺰﻴﻠﻫﺩ ﻭﺩ ﻦﻴﺑ ﺩﺭﺎﮐﻮﻴﻣ ﻭ ﺪﻧﺩﻮﺑ ﻩﺎﺗ
ﻫ ﺪﻳﺭﻭ ﻭ ﺎﻫ ﺍﻭﺎﮐ ﺎﻨﻳﻭ یﺎ
ﺪﻧﺩﻮﺑ کﺯﺎﻧ .
ﺭﺎﻴﺴﺑ ﺪﻳﺩﺮﮔﺮﮐﺫ ﻻﺎﺑﺭﺩ ﻪﮐ ﻩﺩﺭﻭﺍ ﻑﺍﺮﻃﺍ ﺩﺭﺎﮐﻮﻴﻣﺮﺘﺸﻴﺑ ﻪﻤﻫﺯﺍ
ﺪﻧﺩﻮﺑ یﺩﺎﻤﺘﻣ ﺎﻧ ﻭ کﺯﺎﻧ .
ﻪﺣﺎﺳ ﺭﺩ ﻪﮐ ﻢﻳﺩﻮﻤﻧ ﺖﺑﺎﺛ ﺎﻣ ﻢﺠﻨﭘ ﻞﺼﻓ ﺭﺩ sinus venosus
ﺕﺍﺮﺠﺣ ، posterior heart field
ﻪﻧ
ﻞﻣﺎﮑﺗ ﺭﺩ ﻪﮑﻠﺑ ،ﺪﻧﺭﺍﺩ ﻢﻬﺳ ﺩﺭﺎﮐﻮﻴﻣ ﺭﺎﺘﺧﺎﺳ ﻭ ﻞﻣﺎﮑﺗ ﺭﺩ ﺎﻬﻨﺗ ﻭ ﺎﻫ ﺶﺷ ﻩﺩﺭﻭﺍ ﺭﺍﺪﺟ ﻢﺸﻟ ﺕﻼﻀﻋ
ﺪﻧﺭﺍﺩ ﺍﺭ ﻩﺪﻤﻋ ﻝﻭﺭ ﭗﭼ ﺰﻴﻠﻫﺩ ﺭﺎﺘﺧﺎﺳ ﺭﺩ ﻥﺎﻨﭽﻤﻫ .
ﺕﺍﺮﺠﺣ یﺮﻴﮔ ﻢﻬﺳ ﺭﺩ ﻝﻼﺘﺧﺍ posterior heart
field ﻦﻴﺟ ﺪﻗﺎﻓ یﺎﻬﺷﻮﻣ ﻦﻴﺑ ﺭﺩ ﻪﭽﻧﺎﻨﭼ podoplanin
ﻭ ﺩﺭﺎﮐﻮﻴﻣ ﻞﻣﺭﺎﻧ ﺮﻴﻏ ﻞﻣﺎﮑﺗ ﺚﻋﺎﺑ ،ﺪﺷ ﻩﺪﻳﺩ
ﻪﻴﺣﺎﻧﺭﺩ ﻢﺸﻟ ﺕﻼﻀﻋ sinus venosus
ﺩﺩﺮﮕﻴﻣ .
ﻞﺼﻓﺭﺩ ﺐﻠﻗ ﯽﻃﺎﺒﺗﺭﺍ ﻢﺘﺴﻴﺳ ﻞﻣﺎﮑﺗ ﺭﺩ ﺐﻠﻗ ﯽﻔﻠﺧ ﻪﺣﺎﺳ ﻝﻭﺭ ﻢﺸﺷ ‘cardiac conduction
system’
ﺖﺳﺍ ﻩﺪﻳﺩﺮﮔ ﺢﻴﺿﻮﺗ ﻞﺼﻔﻣ ﺕﺭﻮﺼﺑ .
ﺚﺤﺑ ﺩﺭﻮﻣ ﯽﻃﺎﺒﺗﺭﺍ ﻢﺘﺴﻴﺳ ﻒﻠﺘﺨﻣ یﺎﻫﺮﮐﺭﺎﻣ ﺭﺍﺮﻗ
ﺖﺳﺍ ﻪﺘﻓﺮﮔﺭﺍﺮﻗ ﻪﻌﻟﺎﻄﻣ ﺩﺭﻮﻣﺮﺘﻬﺑ ﻞﮑﺷ ﻪﺑ ﻢﺘﺴﻴﺳ ﻦﻳﺍ ﺎﻬﻧﺁ ﮏﻤﮐ ﻪﺑ ﻭ ﻪﺘﻓﺮﮔ .
ﻦﻴﺟ ﻝﻭﺭ ﻦﻤﺿﺭﺩ
ﺗ ﺖﻤﺴﻗ ﺭﺩ ﻦﻴﻧﻼﭘﻭﺩﻮﭘ ﻭ ﺐﻠﻗ ﯽﻃﺎﺒﺗﺭﺍ ﻢﺘﺴﻴﺳ ﻞﻣﺎﮑ
ﺭﺩ ﺐﻠﻗ ﻢﺘﻳﺭ ﺵﻮﺸﺗ ﯽﮑﻴﻨﻴﻠﮐ ﺐﻗﺍﻮﻋ ﻪﺣﺎﺳ
sinus
venosus ﺖﺳﺍ ﻪﺘﻓﺮﮔ ﺭﺍﺮﻗ ﯽﺑﺎﻳﺯﺭﺍ ﺩﺭﻮﻣ
.
!"#
ﺐﻠﻗ ﻞﻣﺎﮑﺗﺭﺩﻮﻧ ﻦﻴﺟ ﮏﻳ ﻪﻌﻟﺎﻄﻣ ﺎﺑ ﻞﺼﻓ ﻦﻳﺍﺭﺩ ،
ﻞﮑﺷ ﮏﻳ ﻪﺑ ﺪﻧﺪﻳﺩﺮﮔﺮﮐﺫ ﻻﺎﺑﺭﺩ ﻪﮐ یﺎﻬﺸﻫﻭﮋﭘ
ﺢﻴﺿﻮﺗ ﺢﺿﺍﻭ ﻩﺪﻳﺩﺮﮔ
. ﻮﺘﮑﻓ ﻦﺸﭘﺮﮑﺴﻧﺮﺗ ﻝﻭﺭ
‘Specificity protein 3 (Sp3)’
ﻪﺣﺎﺳ ﻦﻴﺟ ﮏﻳ ﻪﮐ
ﺖﺳﺍ ﻪﺘﻓﺮﮔﺭﺍﺮﻗ ﺎﻣ ﺶﻫﻭﮋﭘ ﺩﺭﻮﻣ ،ﺩﺭﺍﺩ ﻝﻭﺭ یﺪﻳﺭﻭ ﺐﻄﻗ ﻞﻣﺎﮑﺗ ﺖﻤﺴﻗﺭﺩﻭ ﺪﺷﺎﺒﻴﻣ ﺐﻠﻗ ﯽﻣﻭﺩ .
ﻭ ﻢﻳﺩﺭﺎﮐ ﯽﭘﺍ ﻝﻭﺭ ﻞﺼﻓ ﻦﻳﺍﺭﺩ ﻥﺎﻨﭽﻤﻫ ﯽﺗﺍﺮﺠﺣ
EPDC’s ﺎﻬﻧﺁ یﺮﻴﮔ ﻢﻬﺳ ﻭ ﺪﻧﺮﻴﮕﻴﻣ ًﺎﺸﻨﻣﺮﺳ ﻥﺁﺯﺍ ﻪﮐ
ﺖﺳﺍ ﻩﺪﻳﺩﺮﮔ ﻥﺎﻴﺑ ﺮﮕﻳﺩﺭﺎﺒﮑﻳ ﺩﺭﺎﮐﻮﻴﻣﺭﺎﺘﺧﺎﺳ ﻭ ﻞﻣﺎﮑﺗﺭﺩ .
! #
ﻢﺘﺸﻫ ﻞﺼﻓ ﻭ ﻦﻴﻧﻼﭘﻭﺩﻮﭘ یﺎﻬﻨﻴﺟ ﻝﻭﺭ ﻪﺑ ﻊﺟﺍﺭ ﺚﺤﺑ ﻭﺮﺟﺯﺍ ﻪﺻﻼﺧ
ﺐﻄﻗ ﻞﻣﺎﮑﺗ ﺖﻤﺴﻗﺭﺩ Sp3
ﺐﻠﻗ ﯽﻔﻠﺧ ﻪﺣﺎﺳﺯﺍ یﺪﻳﺭﻭ )
ﻪﭽﻧﺎﻨﭼ ﻡﻭﺩ ﻞﺼﻓ ﺭﺩ ﻼﻋ
ﺪﻳﺩﺮﮔ ﺮﮐﺫ ﻢﺘﻔﻫ (
ﺪﺷﺎﺒﻴﻣ .
