Podoplanin and the posterior heart field : epicardial-myocardial interaction
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(2) Podoplanin and the Posterior Heart Field. Epicardial - Myocardial Interaction. Edris Ahmad Faiz Mahtab.
(3) Colofon Podoplanin and the Posterior Heart Field. Epicardial – Myocardial Interaction Edris Ahmad Faiz Mahtab This thesis was prepared at the Department of Anatomy & Embryology of the Leiden University Medical Center, Leiden, The Netherlands. Cover Front: Artist’s impression of this thesis Back: Afghan carpet Design and lay-out by Kambiz Radjabzadeh. Copyright © 2008 Edris A.F. Mahtab All rights reserved. No part of this book may be reproduced or transmitted, in any form or by any means, without written permission of the author. ISBN 978-90-9023317-8 Printed by Gildeprint Drukkerijen B.V. - www.gildeprint.nl.
(4) Podoplanin and the Posterior Heart Field Epicardial - Myocardial Interaction. Proefschrift. ter verkrijging van de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. P.F. van der Heijden, volgens besluit van het College voor Promoties te verdedigen op dinsdag 21 oktober 2008 klokke 14.15 uur. door. Edris Ahmad Faiz Mahtab geboren te Kabul, Afghanistan 1983.
(5) Promotiecommissie Promotores. Prof. Dr. A.C. Gittenberger- de Groot Prof. Dr. R.E. Poelmann. Co-promotor. Dr. M.R.M. Jongbloed. Referent. Prof. Dr. M.G. Hazekamp. Overige leden. Prof. Dr. A. van der Laarse Dr. N.A. Blom. Financial support of the Netherlands Heart Foundation and of the ‘J.E. Jurriaanse Stichting’ for the publication of this thesis is gratefully acknowledged..
(6) Voor mijn ouders: mijn steunpilaar op aarde en mijn beschermengel in de hemel.. .
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(12) Contents. Chapter 1. General Introduction. Chapter 2. Nkx2.5-Negative Myocardium of the Posterior Heart Field and Its. 9. 21. Correlation with Podoplanin Expression in Cells from the Developing Cardiac Pacemaking and Conduction System. Anatomical Record 2007; 290:115-122.. Chapter 3. Cardiac Malformations and Myocardial Abnormalities in. 41. Podoplanin Knockout Mouse Embryos: Correlation with Abnormal Epicardial Development. Developmental Dynamics 2008; 273:847-857.. Chapter 4. Podoplanin Deficient Mice Show a RhoA Related Hypoplasia of the. 65. Sinus Venosus Myocardium Including the Sinoatrial Node. Submitted for Publication. Chapter 5. Pulmonary Vein, Dorsal Atrial Wall and Atrial Septum. 87. Abnormalities in Podoplanin Knockout Mice with Disturbed Posterior Heart Field Contribution. Pediatric Research, In Press. Chapter 6. Development of the Cardiac Conduction System and the Possible Relation to Predilection Sites of Arrhythmogenesis, with Special Emphasis on the Role of the Posterior Heart Field. The Scientific World Journal 2008; 8:239-269.. 105.
(13) Chapter 7. Transcription Factor Sp3 Knockout Mice Display Serious Cardiac. 149. Malformations. Molecular and Cellular Biology 2007; 27:8571-8582.. Chapter 8. General Discussion and Summary. 175. Samenvatting. 191.
(14) . 197. Acknowledgments. 201. Curriculum Vitae. 205.
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