Towards new therapeutic strategies in chondrosarcoma Schrage, Y.M.

Schrage, Y.M.

Citation

Schrage, Y. M. (2009, November 5). Towards new therapeutic strategies in chondrosarcoma. Retrieved from https://hdl.handle.net/1887/14327

Version: Corrected Publisher’s Version

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Contents

7.1 Histological distinction between benign and low-grade malignant cartilaginous tumours

7.2 Prognostic markers superior to histological grading

7.3 New therapeutic strategies for metastatic and irresectable chondrosarcoma

7.4 Concluding remarks



7.1 Histological distinction between benign and low-grade malignant cartilaginous tumours

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or open chromatin.

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outcome of cartilaginous tumours.

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of long term follow up data. Both CDK4 and MDM2DUHORFDWHGDWT



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depending on histological grade.

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7.3 New therapeutic strategies in chondrosarcoma treatment

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the development of enchondromas and central chondrosarcomas. Central cartilaginous tumours were shown to have normal EXT1 and EXT2 H[SUHVVLRQZKLFKLVLQFRQWUDVWWRSHULSKHUDOWXPRXUVZLWKORZEXT1 and EXT2H[SUHVVLRQGXHWRJHQHWLFORVVLQVSRUDGLFWXPRXUV^ or inactivating PXWDWLRQVLQKHUHGLWDU\WXPRXUV^. In central cartilaginous tumours, active Indian hedgehog signalling was found. Indian hedgehog is important for the UHJXODWLRQ RI QRUPDO ORQJLWXGLQDO ERQH JURZWK &\FORSDPLQH D KHGJHKRJ

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the importance of prevention of malignant progression is evident to improve prognosis.

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