Citation
Hameetman, L. (2007, April 26). The role of EXT and growth signalling pathways in
osteochondroma and its progression towards secondary peripheral chondrosarcoma.
Department Pathology, Faculty of Medicine / Leiden University Medical Center (LUMC),
Leiden University. Retrieved from https://hdl.handle.net/1887/11865
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/11865
The role of EXT and growth signalling
pathways in osteochondroma and its
progression towards secondary
peripheral chondrosarcoma
All rights reserved. No part of this thesis may be reproduced or transmitted in any form, by
The role of EXT and growth signalling
pathways in osteochondroma and its
progression towards secondary
peripheral chondrosarcoma
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op donderdag 26 april 2007
klokke 15.00 uur
door
Liesbeth Hameetman geboren te Gouda
in 1978
Prof. Dr. M.H. Breuning Prof. Dr. A. Vortkamp
(University Duisburg-Essen, Essen, Germany)
Financial support:
The studies described in this thesis were financially supported by the Dutch Cancer Society (RUL-2002-2738), who received additional financial support from the Terry Fox Run.
The printing of this thesis was financially supported by the Dutch Cancer Society (KWF), the J.E. Jurriaanse stichting and Dako Netherlands bv.
CONTENTS Chapter 1 Chapter 2
Chapter 3
Chapter 4
Chapter 5
Chapter 6
Chapter 7
Chapter 8
General introduction
Multiple Osteochondromas: Clinocopathological and Genetic Spectrum and Suggestions for Clinical Management Hereditary Cancer in Clinical Practice (2004); 2(4):161-173
Resolving the role of EXT1 in non-hereditary osteochondroma:
identification of homozygous deletions
Journal of the National Cancer Institute (2007) 99: In press
Decreased EXT expression and intracellular accumulation of HSPG in osteochondromas and peripheral chondrosarcomas
Journal of Pathology 2007; 211(4): 399-409
Peripheral chondrosarcoma progression is accompanied by decreased Indian Hedgehog (IHH) signalling
Journal of Pathology (2006) 209(4): 501-511
The use of BCL2 and PTHLH immunohistochemistry in the diagnosis of peripheral chondrosarcoma in a clinicopathological setting Virchows Archiv (2005) 446: 430-437
EXT-related pathways are not involved in pathogenesis of Dysplasia Epiphysealis Hemimelica and Metachondromatosis
Journal of Pathology (2006) 209(3):411-419 Summary and Discussion
Nederlandse samenvatting List of publications Curriculum Vitae Nawoord
1 29
49
69
87
109
123
137
149 159 161 163
