Citation
Puijvelde, G. H. M. van. (2007, June 28). Regulation of T cell responses in atherosclerosis.
Retrieved from https://hdl.handle.net/1887/12149
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Regulation of T cell responses in atherosclerosis
Regulation of T cell responses in atherosclerosis
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op donderdag 28 juni 2007 klokke 15.00 uur
door
Gijsbrecht Henricus Maria van Puijvelde
geboren te Terneuzen in 1978
The studies described in this thesis were supported by a grant of the Nether- lands Heart Foundation (NHF-2000T040) and were performed at the Division of Biopharmaceutics, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, the Netherlands. Financial support by the Netherlands Heart Foundation for publication of this thesis is gratefully acknowledged.
The realization of this thesis was also financially supported by:
- Leiden University - J.E. Jurriaanse Stichting - LACDR
- Bristol-Myers Squibb - Dr. Ir. van de Laar Stichting
Luctor et Emergo
”Ik worstel en kom boven”
Zeeland - 1585
Aan mijn ouders voor Elze
Table of Contents
Page
Chapter 1 General Introduction 9
Chapter 2 Induction of oral tolerance to oxidized LDL ameliorates atherosclerosis
39
Chapter 3 Induction of oral tolerance to HSP60 or an HSP60- peptide activates T cell regulation and reduces atherosclerosis
55
Chapter 4 Immunotherapy of atherosclerosis using dendritic cells
71
Chapter 5 The effect of NKT cell activation on atherosclerosis depends on apoE and lipid loading
87
Chapter 6 Immunomodulation with OCH-pulsed dendritic cells attenuates atherosclerosis
101
Chapter 7 Effect of deficiency in the natural killer T cell specific Vα14-Jα281 receptor on atherosclerosis in LDL recep- tor deficient mice
119
Chapter 8 Summary and perspectives 131
Nederlandse samenvatting 145
List of abbreviations 151
List of publications 153
Curriculum Vitae 157
Nawoord 159
