Pharmacogenetics of methotrexate in patients with
rheumatoid arthritis
Wessels, J.A.M
Citation
Wessels, J. A. M. (2007, October 11). Pharmacogenetics of
methotrexate in patients with rheumatoid arthritis. Retrieved from
https://hdl.handle.net/1887/12436
Version: Corrected Publisher’s Version
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doctoral thesis in the Institutional Repository of
the University of Leiden
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stellingen judith wessels
1. The response to methotrexate in patients with recent-onset rheumatoid arthritis can be predicted. Dit proefschrift
2. Currently available pharmacogenetic data do not provide results that lead to suggestions about the relationship between genotype and methotrexate induced hepatotoxicity. Dit proefschrift
3. Single nucleotide polymorphisms in genes coding for folate pathway and ade- nosine-release related enzymes are associated with methotrexate treatment outcome in patients with recent-onset rheumatoid arthritis. Dit proefschrift 4. Neglecting the impact of nongenetic factors on methotrexate treatment
outcome will lead to confounded associations. Dit proefschrift
5. Drug-induced liver injury is a major cause for failure of drug candidates before approval as well as for withdrawal of approved drugs after marketing, and the leading cause for acute liver failure, exceeding all other causes combined.
FDA, www.fda.gov (accessed on April 24, 2007)
6. The greater the flexibility in designs, definitions, outcomes and analytical modes in a scientific field, the less likely the research findings are to be true.
JPA Ioannidis, PloS Med 2005; 2:e124
7. For an unbiased view of the evidence for and against any particular associa- tion, study quality, rather than significant value, needs to play the dominant part. AT Hattersley et al., Lancet 2005; 366:315–23
8. De geneeskunde heeft zo’n enorme ontwikkeling doorgemaakt dat er nage- noeg geen gezond mens meer is. Aldous Huxley
9. Consilience should be encouraged.
10. The fact that more knowledge is associated with an increase of the life expectancy with 3 to 4 years is the evidence that investing in educational level in comparison with several preventive medicinal treatment strategies will be more beneficial.
