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Novel insights in reperfusion therapy and stent thrombosis in the drug eluting stent era

Hassan, A.K.M.

Citation

Hassan, A. K. M. (2009, January 14). Novel insights in reperfusion therapy and stent

thrombosis in the drug eluting stent era. Retrieved from https://hdl.handle.net/1887/13406

Version: Corrected Publisher’s Version

License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden

Downloaded from: https://hdl.handle.net/1887/13406

Note: To cite this publication please use the final published version (if applicable).

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Novel insights in

reperfusion therapy and stent thrombosis in the drug eluting stent era

Ayman Khairy Mohamed Hassan

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The studies described in this thesis were performed at the department of Cardiology of the Leiden University Medical Center, the Netherlands.

Copyright ©Ayman Khairy Mohamed Hassan, Leiden, the Netherlands. All rights reserved.

No part of this book may be reproduced or transmitted in any form or by any means, without prior written permission of the author.

Lay out: Legatron Electronic Publishing

Printed by: PrintPartners Ipskamp, Enschede (www.ppi.nl) ISBN: 978-90-9023809-8

Financial support to the costs associated with the publication of this thesis from Cardiology department, Leiden University Medical Center, Leiden, the Netherlands.

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Novel insights in reperfusion therapy and stent thrombosis in the drug eluting stent era

Proefschrift

ter verkrijging van

de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof.mr. P.F. van der Heijden,

volgens besluit van het College voor Promoties te verdedigen op woensdag 14 januari 2009

klokke 15:00 uur

door

Ayman Khairy Mohamed Hassan

Geboren te Assiut, Egypt 1975

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Promotiecommissie

Promoters: Prof. dr. J.W.Jukema Prof. dr. M.J.Schalij

Referent: Prof. dr. A.H. Zwinderman

(Academic Medical centre, University of Amsterdam, Amsterdam)

Overige leden: Prof. dr. A. van der Laarse Prof. dr. E.E. van der Wall Dr. D.E. Atsma

Prof. dr. R. Klautz

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To the soul of my precious mother To my great father and my dear

sister

To my little family……….., My lovely wife mona

my son mostafa

and my daughter salwa

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TABLE OF CONTENTS

Chapter 1 General introduction and outline of the thesis 9

Chapter 2 In-ambulance abciximab administration in STEMI patients prior to 27 primary PCI is associated with smaller infarct size, improved LV function and lower incidence of heart failure: Results from the Leiden MISSION!

acute myocardial infarction treatment optimization program

Chapter 3 Incidence, patient’s characteristics and predictors of aborted myocardial 43 infarction in patients undergoing primary PCI: prospective study

comparing pre- and in-hospital abciximab pretreatment

Chapter 4 Aborted myocardial infarction in patients undergoing primary PCI: 59 long term outcomes

Chapter 5 Usefulness of Peak Troponin-T to Predict Infarct Size and Long-Term 71 Outcome in Patients with First Acute Myocardial Infarction after Primary Percutaneous Coronary Intervention

Chapter 6 The risk of late acquired stent malapposition is higher after drug-eluting 87 stent compared to bare-metal stent implantation and is associated with late stent thrombosis: Meta-analysis and systematic review

Chapter 7 Summary, conclusions and Future perspectives 103

Chapter 8 Samenvatting en conclusie 109

Acknowledgments 115

Curriculum vitae 117

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