Citation
Balog, C. I. A. (2010, November 30). Metabolomics, peptidomics and
glycoproteomics studies on human schistosomiasis mansoni. Department of Parasitology, Faculty of Medicine / Leiden University Medical Center (LUMC), Leiden University. Retrieved from
https://hdl.handle.net/1887/16188
Version: Corrected Publisher’s Version
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
Downloaded from: https://hdl.handle.net/1887/16188
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MetaboloMics, peptidoMics and glycoproteoMics studies on huMan schistosoMiasis Mansoni
Bruker Daltonics, Germany Dionex Benelux B.V.
Cover design: Wim Kooij
Layout and printing: Off Page, Amsterdam
Copyright © 2010 by C. Balog. All rights reserved.
No part of this book may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior permission of the author.
MetaboloMics, peptidoMics and glycoproteoMics studies on huMan schistosoMiasis Mansoni
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus Prof. Mr. P.F. van der Heijden,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 30 november 2010
klokke 13:45 uur
door
crina-ionela-ana balog geboren te Baia Mare, Roemenië in 1974
O singura rugaciune am: Doamne sa nu ma lasi niciodata sa fiu multumit de mine insumi!
(Ik heb maar één wens: Heer, laat mij nooit tevreden met mijzelf worden!) Lucian Blaga
Madrid, Spain) Prof. Dr. J.T. van Dissel
Dr. M.M.A. Olsthoorn (DSM Biology Center, Delft, The Netherlands)
Prof. Dr. P. Slagboom
Prof. Dr. H. Thiele (Bruker Daltonics, Bremen, Germany) Prof. Dr. R.A.E.M. Tollenaar
Dr. B.J. Vennervald (DBL-Institute for Health Research and Development, Copenhagen, Denmark)
General introduction 9 Novel automated biomarker discovery
workflow for urinary peptidomics 43
The feasibility of mass spectrometry and advanced data
processing for monitoring Schistosoma mansoni infection 61 Metabonomic investigation of human
Schistosoma mansoni infection 85
IPSE/alpha-1, a major secretory glycoprotein antigen from schistosome eggs, expresses the Lewis X motif
on core-difucosylated N-glycans 113
Mass spectrometric identification of aberrantly glycosylated human Apolipoprotein C-III peptides
in urine from Schistosoma mansoni-infected individuals 141
General discussion 171
Summary 178
Samenvatting 182
Dankwoord 186
Curriculum Vitae 189
List of publications 190
table of contents
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5
Chapter 6
Chapter 7 Addendum
