Cover Page
The handle http://hdl.handle.net/1887/44019 holds various files of this Leiden University dissertation.
Author: Steenbergen, H.W. van
Title: The course of clinically suspect arthralgia and early rheumatoid arthritis : clinical features, imaging and genetics
Issue Date: 2016-11-08
The course of Clinically Suspect Arthralgia and early
Rheumatoid Arthritis
Clinical features, imaging and genetics
Hanna van Steenbergen 2016
The studies described in this thesis were performed at the Department of Rheumatology of the Leiden University Medical Centre, Leiden, the Netherlands
ISBN/EAN: 978-94-623-33307
Printing of the thesis was supported by the Dutch Arthritis Foundation, Stichting MCH en Bronovo- Nebo, Pfizer BV, AbbVie BV, UCB Pharma BV and ChipSoft.
Cover design and thesis layout: Martin Berndsen Printing: Gildeprint - Enschede
Copyright © 2016 by Hanna van Steenbergen
All Rights reserved. No part of this book may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior permission of the author.
The course of Clinically Suspect Arthralgia and early Rheumatoid Arthritis
Clinical features, imaging and genetics
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, Op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 8 november 2016
klokke 15:00 uur
Door Hanna Willemijn van Steenbergen geboren te Delft
in 1988
Promotores Prof. dr. T.W.J. Huizinga
Prof. dr. A.H.M. van der Helm-Van Mil
Leden promotiecommissie Prof. dr. G. Kloppenburg
Prof. dr. R.B.M. Landewé (AMC/Universiteit van Amsterdam) Prof. dr. J. Houwing-Duistermaat
Prof. dr. M. Hazes (Erasmus MC)
CONTENTS
Chapter 1 Introduction 7
Part I: Phase of Clinically Suspect Arthralgia
Chapter 2 The preclinical phase of rheumatoid arthritis: what is
acknowledged and what needs to be assessed? 23 Chapter 3 Characterising arthralgia in the preclinical phase of rheumatoid
arthritis using MRI 45
Chapter 4 Subclinical inflammation on MRI of hand and foot of ACPA- negative arthralgia patients at risk for rheumatoid arthritis 61 Chapter 5 Clinical factors, ACPA and MRI-detected subclinical
inflammation in relation to progression from Clinically Suspect Arthralgia to arthritis
73
Chapter 6 Clinical expertise and its accuracy in differentiating arthralgia patients at risk for rheumatoid arthritis from other patients presenting with joint symptoms
93
Chapter 7 EULAR definition of arthralgia suspicious for progression to
rheumatoid arthritis. 97
Part II: Genetic factors and disease outcome in rheumatoid arthritis Chapter 8 Predicting the severity of joint damage in rheumatoid arthritis;
the contribution of genetic factors 113
Chapter 9 Does a genetic variant in FOXO3A predict a milder course of
rheumatoid arthritis? – a multi-cohort study 129 Chapter 10 SPP1 rs9138 variant contributes to the severity of radiological
damage in ACPA-negative rheumatoid arthritis 137 Chapter 11 A genetic study on C5-TRAF1 and progression of joint damage
in rheumatoid arthritis 145
Chapter 12 Association of Valine and Leucine at HLA-DRB1 position 11 with radiographic progression in rheumatoid arthritis, independent of the shared epitope alleles but not independent of ACPA
163
Chapter 13 IL2RA is associated with persistence of rheumatoid arthritis 181 Chapter 14 Osteoprotegerin as biomarker for persistence of rheumatoid
arthritis 197
Part III: Other outcomes in rheumatoid arthritis
Chapter 15 DMARD-free sustained remission in rheumatoid arthritis: an increasingly achievable outcome with subsidence of disease symptoms
203
Chapter 16 Fatigue in rheumatoid arthritis; a persistent problem: a large
longitudinal study 219
Chapter 17 Summary and discussion 235
Chapter 18 Nederlandse samenvatting 251
Curriculum Vitae 259
Publications 260
Dankwoord 265
