Cover Page
The handle
http://hdl.handle.net/1887/97600
holds various files of this Leiden University
dissertation.
Author:
Boer, A.C.
Title: Clinically suspect arthralgia and early rheumatoid arthritis : advances in imaging
and impact on daily life
Clinically Suspect Arthralgia and Early
Rheumatoid Arthritis
Advances in imaging and impact on daily life
The studies described in this thesis were performed at the Department of Rheumatology of the Leiden University Medical Centre, Leiden, the Netherlands
ISBN/EAN: 978-94-640-22278 Cover design: Hanne Snel Printing: Gildeprint - Enschede Copyright © 2020 by Aleid Boer
Clinically Suspect Arthralgia and Early
Rheumatoid Arthritis
Advances in imaging and impact on daily life
Proefschrift
ter verkrijging van de graad van doctor aan de Universiteit Leiden, op gezag van de Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties, te verdedigen op dinsdag 9 juni 2020 om 15:00 uur
door Aleid Christine Boer geboren te Den Hout
Promotores Prof. dr. A.H.M. van der Helm - van Mil Prof. dr. T.W.J. Huizinga
Leden promotiecommissie Prof. dr. A.W.M. Evers
Contents
1 General introduction 1
I Advances in imaging 17
2 Using a reference when defining an abnormal MRI reduces false-positive
MRI-results 19
3 The use of MRI-detected synovitis to determine the number of involved joints for the 2010 ACR/EULAR classification criteria for Rheumatoid Arthritis – is it
of additional benefit? 31
4 Do musculoskeletal ultrasound and magnetic resonance imaging identify synovitis and tenosynovitis at the same joints and tendons? A comparative study in early inflammatory arthritis and clinically suspect arthralgia 43 5 Improving the feasibility of MRI in clinically suspect arthralgia for prediction of
rheumatoid arthritis by omitting scanning of the feet 69
II Impact on daily life 87
6 Is ACPA-positive RA still a more severe disease than ACPA-negative RA? 89 7 Does psychological stress in patients with clinically suspect arthralgia associate
with subclinical inflammation and progression to inflammatory arthritis? 111 8 Depression and anxiety associate with less remission after 1 year in rheumatoid
arthritis 127
9 The contribution of tenosynovitis of small joints to the symptom morning stiffness in patients presenting with Undifferentiated and Rheumatoid Arthritis 133
III General discussion and summary 147
10 Discussion and summary 149
11 Nederlandse samenvatting 165
Curriculum Vitae 175
List of Publications 177
Dankwoord 179
