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The following handle holds various files of this Leiden University dissertation:
http://hdl.handle.net/1887/58873 Author: Chen, X.
Title: Human pharmacology of current and novel gaba(a)-ergic treatments for anxiety
Issue Date: 2017-10-17
human pharmacology of current and novel gaba(a)-ergic treatments for anxiety 168
list of publications
Chen X, Broeyer F, de Kam M, Baas J, Cohen A, van Gerven J. Pharmacodynamic response profiles of anxiolytic and sedative drugs. Br J Clin Pharmacol. 2017 May;
83(5):1028-1038. doi: 10.1111/bcp.13204. Epub 2017 Mar 17.
Te Beek ET, Chen X, Jacobs GE, Nahon KJ, de Kam ML, Lappalainen J, Cross AJ, van Gerven JM, Hay JL. The effects of the nonselective benzodiazepine loraze- pam and the α2 /α3 subunit-selective gabaA receptor modulators azd7325 and azd6280 on plasma prolactin levels. Clin Pharmacol Drug Dev. 2015 Mar;4(2):149- 54. doi: 10.1002/cpdd.134.
Chen X, Zuiker RG, Østerberg O, Mirza NR, Muglia P, de Kam M, Klaassen ES, van Gerven JM. ns11821, a partial subtype-selective gabaA agonist, elicits selec- tive effects on the central nervous system in randomized controlled trial with healthy subjects. J Psychopharmacol. 2016 Mar; 30(3): 253-62. doi: 10.1177 / 0269881115620435.
Chen X, Jacobs G, de Kam ML, Jaeger J, Lappalainen J, Maruff P, Smith MA, Cross AJ, Cohen A, van Gerven J. azd6280, a novel partial γ-aminobutyric acid A receptor modulator, demonstrates a pharmacodynamically selective effect profile in healthy male volunteers. J Clin Psychopharmacol. 2015 Feb;35(1):22-33. doi: 10.1097/
JCP.0000000000000251.
Chen X, Jacobs G, de Kam M, Jaeger J, Lappalainen J, Maruff P, Smith MA, Cross AJ, Cohen A, van Gerven J. The central nervous system effects of the partial gaba- aα2,3 -selective receptor modulator azd7325 in comparison with lorazepam in healthy males. Br J Clin Pharmacol. 2014 Dec;78(6):1298-314. doi: 10.1111/bcp.12413.
Chen X, de Haas S, de Kam M, van Gerven J. An Overview of the cns-Pharmacody- namic Profiles of Nonselective and Selective gaba Agonists. Adv Pharmacol Sci.
2012;2012:134523. doi: 10.1155/2012/134523. Epub 2012 Jan 29.
Baas JM, Mol N, Kenemans JL, Prinssen EP, Niklson I, Chen X, Broeyer F, van Gerven J.
Validating a human model for anxiety using startle potentiated by cue and context: the effects of alprazolam, pregabalin, and diphenhydramine. Psycho- pharma cology (Berl). 2009 Jul; 205(1): 73-84.
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