Cover Page
The handle http://hdl.handle.net/1887/54938 holds various files of this Leiden University dissertation.
Author: Jong, S.E. de
Title: Immunological differences between urban and rural populations
Issue Date: 2017-10-18
Immunological differences
between urban and rural populations
ISBN 978-94-6299-715-8
© 2017 Sanne E. de Jong
The work presented in this thesis was performed at the Department of Parasitology of the Leiden University Medical Center in the Netherlands.
Printing of this thesis was financially supported by ChipSoft.
Printing: Ridderprint BV, www.ridderprint.nl
Immunological differences
between urban and rural populations
Proefschrift ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 18 oktober 2017
klokke 15:00 uur
door
Sanne Eveline de Jong
geboren te Alphen aan den Rijn in 1988
Promotores
Prof. Dr. M. Yazdanbakhsh
Prof. Dr. P. G. Kremsner (University of Tübingen, Germany)
Leden promotiecommissie
Prof. Dr. S. H. van der Burg Prof. Dr. F. Koning Prof. Dr. C. van Kooten
Prof. Dr. E. C. de Jong (Academic Medical Center Amsterdam)
5
Table of contents
1. General introduction 6
2. Changes in antigen-specific IgG1 Fc N-glycosylation upon influenza and tetanus vaccination
12
3. IgG1 Fc N-glycan galactosylation as a biomarker for immune activation 34 4. Differences in innate cytokine responses between European and African children 56 5. Changes in immunological profile as a function of urbanization and life style 72 6. Immunological differences between European and African young adults 92
7. Natural immunity to controlled malaria infection in Europeans and Africans analysed by mass cytometry
118
8. Longitudinal study of changes in γδ T cells and CD4+ T cells upon asymptomatic malaria infection in Indonesian children
152
9. Summarising discussion 172
Appendices
Nederlandse samenvatting 184
Acknowledgements 187
Curriculum vitae 189
List of publications 190
