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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded.

The research described in this thesis was performed at the Department of Rheumatology of the Leiden University Medical Center, and was financially supported by the Netherlands

Given that the disease in Scurfy mice can be transplanted into a T-cell deficient host upon the transfer of CD4 + T cells (36), these immunological similarities between Scurfy

Although the highest expression of CD25 (termed CD25 high or CD25 ++ ) on CD4 + T cells is now widely used to identify, isolate, and characterize naturally occurring Treg cells

Therapies based on CD4 + CD25 + FOXP3 + T regulatory (Treg) cells offer promise for the restoration of tolerance in many immune-mediated disorders. However, it has been proven

/ATRA-induced Treg conversion, as 1) neutralization of IL-4 during activation induces.. high numbers of Foxp3 + Treg cells; 2) no detectable levels of IL-4 are observed from

In light of the great therapeutic potentials of in vitro activated/expanded Tregs for various inflammatory diseases in animals (16-19, 104), protocols have been developed

Geïntrigeerd door onze humane data behandeld in Hoofdstuk 4 waaruit blijkt dat er sprake is van een inconsistente inductie van Tregs door TGF- en ATRA van CD4 + CD25 -