University of Groningen
The multifactorial nature of food allergy
van Ginkel, Cornelia Doriene
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Publication date: 2018
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van Ginkel, C. D. (2018). The multifactorial nature of food allergy. Rijksuniversiteit Groningen.
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THE MULTIFACTORIAL NATURE OF FOOD ALLERGY
PHD THESIS
Copyright © 2018 by Dorien Westerlaken - van Ginkel, Zwolle, The Netherlands Cover design by Dorien Westerlaken - van Ginkel
Lay-out by Erik Westerlaken, Dorien Westerlaken - van Ginkel and Ridderprint Printed by Ridderprint
Financial support for the publication of this thesis was provided by Nutricia Early Life Nutrition, Mylan laboratories, Allergy Therapeutics, Danone Nutricia Research, ALK-Abelló, Mead Johnson Nutrition, the University of Groningen, Graduate School of Medical Sciences & University Medical Center Groningen.
ISBN 978-94-034-1098-2 (printed version) ISBN 978-94-034-1099-9 (electronic version)
The multifactorial nature of food
allergy
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 10 oktober 2018 om 16.15 uur
door
Cornelia Doriene van Ginkel
geboren op 24 april 1991 te Soest
Copyright © 2018 by Dorien Westerlaken - van Ginkel, Zwolle, The Netherlands Cover design by Dorien Westerlaken - van Ginkel
Lay-out by Erik Westerlaken, Dorien Westerlaken - van Ginkel and Ridderprint Printed by Ridderprint
Financial support for the publication of this thesis was provided by Nutricia Early Life Nutrition, Mylan laboratories, Allergy Therapeutics, Danone Nutricia Research, ALK-Abelló, Mead Johnson Nutrition, the University of Groningen, Graduate School of Medical Sciences & University Medical Center Groningen.
ISBN 978-94-034-1098-2 (printed version) ISBN 978-94-034-1099-9 (electronic version)
The multifactorial nature of food
allergy
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 10 oktober 2018 om 16.15 uur
door
Cornelia Doriene van Ginkel
geboren op 24 april 1991 te Soest
Promotores
Prof. dr. A.E.J. Dubois Prof. dr. G.H. Koppelman
Beoordelingscommissie
Prof. dr. H.M. Boezen Prof. dr. A.C. Knulst Prof. dr. S. Weidinger
CONTENTS
PART I - INTRODUCTION
P9 Chapter 1 - General introduction
P19 Chapter 2 - The genetics of allergic disorders
Ginkel C.D. van, Dubois A.E.J., Koppelman G.H. Manual of Allergy and Clinical Immunology for
Otolaryngologists. Editors: David L. Rosenstreich, Marvin P. Fried, Gabriele S. de Vos and
Alexis H. Jackman. Copyricht © 2016 Plural Publishing, Inc
PART II - EPIDEMIOLOGY AND ENVIRONMENTAL FACTORS INFLUENCING FOOD ALLERGY
P47 Chapter 3 - Extremely low prevalence of epinephrine autoinjectors in high-risk food-allergic adolescents in Dutch high schools
Flokstra- de Blok B.M.J., Ginkel C.D. van, Roerdink E.M., Kroeze A.J.M., Stel A.A., Meulen G.N.
van der, Dubois A.E.J. Pediatric Allergy and Immunology 22: 374-7 (2011)
P55 Chapter 4 - Food allergy in 78 890 adults from the northern Netherlands
Ginkel C.D. van, Vonk J.M., Flokstra- de Blok B.M.J., Sprikkelman A.B., Koppelman G.H.,
Dubois A.E.J. Submitted for peer review
P93 Chapter 5 - Retrospective observational cohort study regarding the effect of breastfeeding on challenge-proven food allergy
Ginkel C.D. van, Meulen G.N. van der, Bak E., Flokstra-de Blok B.M.J., Kollen B.J., Koppelman
G.H., Dubois A.E.J. European Journal of Clinical Nutrition 72:557-563 (2018)
P105 Chapter 6 - Effect of birth order and familial atopy on food allergy risk
Ginkel C.D. van and Bak E., KollenB.J., Flokstra-de BlokB.M.J., KoppelmanG.H., Dubois A.E.J.
Submitted for peer review
PART III - GENETICS OF FOOD ALLERGY
P121 Chapter 7 - Loss-of-function variants of the filaggrin gene are associated with clinical reactivity to foods
Ginkel C. D. van, Flokstra-de BlokB.M.J., KollenB.J., Kukler J., Koppelman G.H. and A. E. J.
Dubois. European Journal of Allergy and Clinical Immunology ;70(4):461-4 (2015)
P129 Chapter 8 - Association of STAT6 gene variants with food allergy diagnosed by double- blind placebo-controlled food challenges
Ginkel C.D. van, Pettersson M.E., Dubois A.E.J., Koppelman G.H. European Journal of Allergy
and Clinical Immunology 73;1337-41 (2018)
Promotores
Prof. dr. A.E.J. Dubois Prof. dr. G.H. Koppelman
Beoordelingscommissie
Prof. dr. H.M. Boezen Prof. dr. A.C. Knulst Prof. dr. S. Weidinger
CONTENTS
PART I - INTRODUCTION
P9 Chapter 1 - General introduction
P19 Chapter 2 - The genetics of allergic disorders
Ginkel C.D. van, Dubois A.E.J., Koppelman G.H. Manual of Allergy and Clinical Immunology for
Otolaryngologists. Editors: David L. Rosenstreich, Marvin P. Fried, Gabriele S. de Vos and
Alexis H. Jackman. Copyricht © 2016 Plural Publishing, Inc
PART II - EPIDEMIOLOGY AND ENVIRONMENTAL FACTORS INFLUENCING FOOD ALLERGY
P47 Chapter 3 - Extremely low prevalence of epinephrine autoinjectors in high-risk food-allergic adolescents in Dutch high schools
Flokstra- de Blok B.M.J., Ginkel C.D. van, Roerdink E.M., Kroeze A.J.M., Stel A.A., Meulen G.N.
van der, Dubois A.E.J. Pediatric Allergy and Immunology 22: 374-7 (2011)
P55 Chapter 4 - Food allergy in 78 890 adults from the northern Netherlands
Ginkel C.D. van, Vonk J.M., Flokstra- de Blok B.M.J., Sprikkelman A.B., Koppelman G.H.,
Dubois A.E.J. Submitted for peer review
P93 Chapter 5 - Retrospective observational cohort study regarding the effect of breastfeeding on challenge-proven food allergy
Ginkel C.D. van, Meulen G.N. van der, Bak E., Flokstra-de Blok B.M.J., Kollen B.J., Koppelman
G.H., Dubois A.E.J. European Journal of Clinical Nutrition 72:557-563 (2018)
P105 Chapter 6 - Effect of birth order and familial atopy on food allergy risk
Ginkel C.D. van and Bak E., KollenB.J., Flokstra-de BlokB.M.J., KoppelmanG.H., Dubois A.E.J.
Submitted for peer review
PART III - GENETICS OF FOOD ALLERGY
P121 Chapter 7 - Loss-of-function variants of the filaggrin gene are associated with clinical reactivity to foods
Ginkel C. D. van, Flokstra-de BlokB.M.J., KollenB.J., Kukler J., Koppelman G.H. and A. E. J.
Dubois. European Journal of Allergy and Clinical Immunology ;70(4):461-4 (2015)
P129 Chapter 8 - Association of STAT6 gene variants with food allergy diagnosed by double- blind placebo-controlled food challenges
Ginkel C.D. van, Pettersson M.E., Dubois A.E.J., Koppelman G.H. European Journal of Allergy
and Clinical Immunology 73;1337-41 (2018)
van Ginkel C.D., Dubois A.E.J., Sprikkelman A.B., Xu C., Dijk F.N., Nolte I.M., Marenholz I. et al.
Manuscript in preparation.
P189 Chapter 10 - Genome wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes
c11orf30/EMSY as a genetic risk factor for food allergy
Asai Y. and Eslami A., Ginkel C.D. van, Akhabir L., Wan M., Ellis G., Ben-Shoshan M. et al.
Journal of Allergy and Clinical Immunology 141(3)991-1001 (2018)
P241 Chapter 11 - Canadian genome-wide association study and meta analysis confirm HLA as a risk factor for peanut allergy
Asai Y. and Eslami A., Ginkel C.D. van, Akhabir L., Wan M., Yin D., Ellis G. et al. Journal of
Allergy and Clinical Immunology 141(4)1513-6 (2018)
PART IV – CONCLUDING REMARKS
P267 Chapter 12 - Summary and general discussion
P279 Nederlandse samenvatting P292 Acknowledgements P293 List of publications P295 Curriculum vitae
PART I
INTRODUCTIONvan Ginkel C.D., Dubois A.E.J., Sprikkelman A.B., Xu C., Dijk F.N., Nolte I.M., Marenholz I. et al.
Manuscript in preparation.
P189 Chapter 10 - Genome wide association study and meta-analysis in multiple populations identifies new loci for peanut allergy and establishes
c11orf30/EMSY as a genetic risk factor for food allergy
Asai Y. and Eslami A., Ginkel C.D. van, Akhabir L., Wan M., Ellis G., Ben-Shoshan M. et al.
Journal of Allergy and Clinical Immunology 141(3)991-1001 (2018)
P241 Chapter 11 - Canadian genome-wide association study and meta analysis confirm HLA as a risk factor for peanut allergy
Asai Y. and Eslami A., Ginkel C.D. van, Akhabir L., Wan M., Yin D., Ellis G. et al. Journal of
Allergy and Clinical Immunology 141(4)1513-6 (2018)
PART IV – CONCLUDING REMARKS
P267 Chapter 12 - Summary and general discussion
P279 Nederlandse samenvatting P292 Acknowledgements P293 List of publications P295 Curriculum vitae
PART I
INTRODUCTIONCHAPTER 1
