University of Groningen
Biomarkers in stable and acute exacerbations of COPD Prins, Hendrik J
DOI:
10.33612/diss.136484081
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Prins, H. J. (2020). Biomarkers in stable and acute exacerbations of COPD. University of Groningen. https://doi.org/10.33612/diss.136484081
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Biomarkers in stable and acute
exacerbations of COPD
ISBN: 978-94-034-2679-2 Ontwerp cover: Ria van der Linden
Lay-out by: ProefschriftMaken || www.proefschriftmaken.nl Printed by: ProefschriftMaken || www.proefschriftmaken.nl
Biomarkers in stable and acute
exacerbations of COPD
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 16 november 2020 om 14.30 uur
door
Hendrik Johannes Prins
geboren op 22 november 1982 te Zwolle
Promotor
Prof. dr. T.S. van der Werf
Copromotor
Dr. W.G. Boersma
Beoordelingscommissie
Prof. dr. A.W. Friedrich Prof. dr. J.M. Prins Prof. dr. P.J. Wijkstra
Table of contents
Chapter 1: General introduction 9
Chapter 2: CRP-guided Antibiotic Treatment in acute 27
exacerbations of COPD admitted to Hospital
Chapter 2.1: Safety of CRP-guided antimicrobial treatment in 49
hospitalized AECOPD
Chapter 3: Blood eosinophilia as a marker of early and late 55
treatment failure in severe acute exacerbations of COPD
Chapter 4: Role of low dose computed tomography scans 71
and biomarkers in patients hospitalized with acute exacerbations of COPD
Chapter 5: COPD-Lower Respiratory Tract infection Visual 85
Analogue Score (c-LRTI-VAS) validation in stable and exacerbated COPD patients
Chapter 6: Effects of doxycycline on local and systemic 103
inflammation in stable COPD patients, a randomized clinical trial
Chapter 7: General conclusion and future perspectives 121
Chapter 8: Summary 143
Chapter 9: Nederlandse samenvatting voor niet-ingewijden 149
Chapter 10: Curriculum Vitae 159
Chapter 11: Dankwoord 163
