University of Groningen
Novel aspects of heart failure biomarkers
Suthahar, Navin
DOI:
10.33612/diss.135383104
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Suthahar, N. (2020). Novel aspects of heart failure biomarkers: Focus on inflammation, obesity and sex differences. University of Groningen. https://doi.org/10.33612/diss.135383104
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Stellingen behorende bij het proefschrift
Novel Aspects of
Heart Failure Biomarkers
Navin Suthahar
1. Inflammation is a cause as well as a consequence of heart failure. This thesis 2. Inhibiting galectin-3 activation could emerge as a novel therapeutic strategy for heart failure. This thesis
3. Inflammatory mechanisms link type-2 diabetes mellitus and obesity with incident heart failure. This thesis
4. In the general population, plasma concentrations of several cardiovascular biomarkers are influenced by obesity. This, however, poorly translates to whether a biomarker would differentially relate with heart failure risk across the BMI spectrum. This thesis
5. In the general population, lower natriuretic peptide levels in heavier individuals is better explained by male sex than by obesity. This thesis
6. Cardiac troponins (cTns) are powerful predictors of cardiovascular disease and heart failure in both sexes. However, the cTn threshold in which cardiovascular risk becomes apparent is lower in women than in men. Therefore, even minor cTn elevations should be taken seriously - particularly in women. This thesis
7. Although baseline biomarker levels differ between men and women, equal increases in biomarker levels are associated with similar increases in the risk of heart failure in both sexes. This thesis
8. If your experiment needs statistics, you ought to have done a better experiment. Ernest Rutherford
9. Never let success get to your head; never let failure get to your heart. 10. For what profits a man if he gains the whole world but loses his own soul?
