University of Groningen
Individual behavioural patterns and neural underpinnings of verb processing in aphasia
Akinina, Yulia
DOI:
10.33612/diss.136488344
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Publication date: 2020
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Akinina, Y. (2020). Individual behavioural patterns and neural underpinnings of verb processing in aphasia. https://doi.org/10.33612/diss.136488344
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Individual Behavioural Patterns and Neural
Underpinnings of Verb Processing in Aphasia
The author of this thesis was financially supported by several funders. The paper presented in Chapter 2 is an output of a research project implemented as part of the Basic Research Program at the National Research University Higher School of Economics (HSE). Preparation of the papers presented in Chapters 3 and 4 has been funded by the Center for Language and Brain NRU Higher School of Economics, RF Government grant, ag. No 14.641.31.0004. The work was also partially supported by the Russian Foundation for Humanities (RGNF), grant 11-06-12033v; by Short Term Scientific Mission COST Action IS1208 COST-STSM-ECOST-STSM-IS1208-011014-050781; by the Academic Fund Program at the National Research University Higher School of Economics (HSE) in 2015-2017 (grant №15-01-0110); and by the Russian Academic Excellence Project "5-100". Publication of this thesis was financially supported by the University of Groningen and Stichting Aphasie Nederland (SAN).
Groningen dissertations in linguistics 190 ISSN: 0928-0030
Cover image by Maria Akinina
Layout and cover design by Douwe Oppewal Printed by Ipskamp Printing B.V.
Individual Behavioural Patterns
and Neural Underpinnings of Verb
Processing in Aphasia
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Thursday 12 November 2020 at 12.45 hours
by
Yulia Akinina
born on 19 April 1989
in Moscow, USSR
Supervisor
Prof. Y.R.M. Bastiaanse
Co-supervisor
Dr. O. Dragoy
Assessment Committee
Prof. C.G. Luzzatti
Prof. B.A.M. Maassen
Prof. N.O. Schiller
ACKNOWLEDGMENTS
Doing a PhD is a serious challenge, but you never do it alone. I am greatly indebted to so many people around me who made it possible.
First of all, I dearly thank my supervisors, Prof. dr. Roelien Bastiaanse and Dr. Olga Dragoy, for guiding me, giving me topics and tests to adapt, and providing me with all the unique opportunities in career and life. I owe you tremendously, and I cannot thank you enough.
I thank my reading committee, Prof. Claudio Luzzatti, Prof. dr. Ben Maassen and Prof. dr. Niels Schiller, for taking their time to read my thesis and assess it.
I want to express my gratitude to my senior collaborators and co-authors, Prof. Nina Dronkers and Dr. Maria Ivanova. Although not my formal supervisors, you were indeed my mentors, I learned so much from you, and it was a real pleasure working with you. Thank you to Victor Shklovsky and Roman Cheremin for providing access to the resources of the Center for Speech Pathology and Neurorehabilitation in Moscow, Russia, without which the research with people with aphasia would not be possible. Likewise, special thanks to my clinician colleagues and collaborators Ekaterina Iskra, Elena Mannova and Svetlana Kuptsova, for their help and advice on navigating the real-life clinical setting and the insights from their fields of speech pathology and neuropsychology.
I wholeheartedly thank all our research participants who gave their time to help advance scientific research.
I thank all the co-authors of the papers that are part of this thesis (and now the lists start to intersect!) – Anna Artemova, Roelien Bastiaanse, Olga Buivolova, Olga Dragoy, Nina Dronkers, Oksana Fedina, Maria Ivanova, Ekaterina Iskra, Svetlana Malyutina, Elena Mannova, Alexey Petrushevsky, Viktor Shklovsky, Olga Soloukhina, And Turken, and Andrey Zyryanov. Thank you for your invaluable contributions, it has been so fun working with you! Thanks to the proofreaders of the papers, Kelly Callahan (chapter 1, 2 and 5) and Katrina Gaffney (chapter 4). For the help on chapter 3, I would like to mention our colleagues and collaborators for their invaluable contributions to the paper: Svetlana Malyutina for her helpful comments on the text, Anna Yurchenko for her assistance with lesion data processing, Roelien Bastiaanse for her suggestions for manuscript revisions, and all those who assisted with behavioral data pre-processing (Anna Kotova, Tatiana Rylko, Anastasia Novikova, Julia Edeleva, Grigory Ignatyev, Valeriya Garkavaya, Maria Melnikova, Maria Grabovskaya, Viktoriya Silayeva, Anna Vechkaeva, and Olga Rudina).
For their contributions to the work on chapter 4, I express my gratitude to Lilya Kazakova, Alexey Koshevoy, Oksana Kovaleva, Natalia Krasikova, Taisiya Metelkina, Stepan Mikhailov, Evgeniya Miller, Anastasia Panova, Elena Savinova, Evgeniya Slepak, and Elena Sokur, for their assistance with collection of data. I also thank Ekaterina Iskra for her help with data collection in people with aphasia and for her invaluable clarifications of the standard language diagnostic procedures in the Center for Speech Pathology and Neurorehabilitation.
I would like to express my profound gratitude to my former and now-colleagues at the Center for Language and Brain (formerly Neurolinguistics Lab) in Moscow. Andrey, Anna (A.), Anna (Yu.), Anna (Lau.), Anna (Chr.), Anastasia (K.), Anastasia (L.), Anastasia (S.), Anastasia (Sh.), Daria, Dima, Ekaterina (St.), Ekaterina (T.), Evdokiya, Galina, Grigory, Kirill, Maria (G.), Maria (I.), Maria (Kh.), Nina (L.), Nina (Z.), Olga (S.), Olga (B.), Rosa, Svetlana (M.), Svetlana (D.), Tatiana, Natalia, Nikita, Valeriya (T.), Valeriya (Z.), Vardan, Victor, Victoria, Zara, Zoya – thank you for your support and help with scientific and technical questions, for your intellectually stimulating discussions and for the friendships that I hope will last wherever our future career paths take us.
Thanks to the current and former IDEALABers and members of the Neurolinguistics group: Aida, Annie, Assunta, Camila, Fleur, Frank, Jakolien, Jidde, Juliana, Kaimook, Katya, Liset, Miren, Nat, Nienke, Sana, Seçkin, Silvia, Srđan, Svetlana, Suzy, Pauline, Teja, and Toivo. We were not formally in the same program, but I really enjoyed our time together during my short stays in Groningen, and I learned from you a lot. I really wish we had spent more time together.
Thanks a million to my wonderful paranymphs Annie and Alice who helped me organize everything remotely – quite a challenging task in these challenging corona-times.
Life is not all work, so I will now also mention those outside academia who make my life so much fuller and better.
Many thanks to my choir A Posteriori: its director Danya, choirmasters Ira and Masha, and all the basses, tenors, altos, and fellow sopranos, for the singing we did together over the last two years. It brought me so much joy and gave much needed energy. I would probably not have finished without something like this. Thank you!
Also, special thanks to my dear friends! Masha, I couldn’t choose between ‘my bff’ and ‘my old bestie’, but what can I say? you know everything already. Everyone (sorry for unintentional omissions!) – Alex, Asya, Dasha, Dima, Emil, Gosha, Grisha, Ilona, Ilya, Ilya, Katya, Marianna, Nastya, Nika, Nikita, Sabira, Samer, Tema, Vanya, Uliana, Yasya – I am so lucky to have met you! Thank you for your support, and for just being there. Finally, I express my profoundest gratitude to my family who supported me no matter what. Thanks to my grandpa, a fellow scholar. Sis, I love you more than anything. Mom and dad, I don’t know what I would do without your unconditional support. Thank you, baba Sasha, you are the best; thank you, ded Tolya! And finally, with all my heart, thanks to my grandma Olga, who made it all possible. God, I wish you were here to see this.
TABLE OF CONTENTS
Acknowledgements
1. General introduction
111.1. Aphasia 12
1.2. Verb processing in aphasia 12
1.3. Neural underpinnings of single verb processing 13
1.4. Verb processing and its relation to sentence processing in aphasia 14
1.5. Summary 15
2. Russian Normative Data for 375 Action Pictures and Verbs
172.1. Introduction 19
2.2. Method 30
2.2.1. Stimuli 30
2.2.2. Procedure 31
2.2.3. Participants 33
2.3. Results and discussion 34
2.3.1. Descriptive statistics 34
2.3.2. Correlation analysis 35
2.3.3. Analysis of name disagreement sources 40
2.4. Conclusion 43
3. Grey and white matter substrates of action naming
453.1. Introduction 47
3.1.1. Neural substrates of the lexical-semantic level of word retrieval 47 3.1.2. Neural substrates of lexical-semantic stages of verb processing 49 3.1.3. White matter substrates of lexical-semantic stages of object 51
and action naming
3.1.4. The present study 52
3.2. Materials and methods 54
3.2.1. Participants 54 3.2.2. MRI acquisition 54 3.2.3. MRI preprocessing 55 3.2.4. Lesion analysis 55 3.2.5. Action naming 55 3.2.5.1. Materials 55 3.2.5.2. Procedure 56 3.2.5.3. Scoring 57 3.2.6. VLSM analysis 58 VIII
3.3. Results 59
3.3.1. Action naming results 59
3.3.2. VLSM results 60
3.3.3. Grey and white matter involvement 60
3.4. Discussion 64
3.4.1. Grey matter cortical findings 64 3.4.2. White matter findings: association fibers and cortico-cortical networks 67 3.4.3. Cortico-subcortical networks in action naming 69 3.4.4. Limitations and further directions 71
4. Prevalence of verb and sentence impairment in aphasia as
73demonstrated by cluster analysis
4.1. Introduction 75
4.1.1. The Verb And Sentence Test 76
4.1.2. Cluster analysis 77
4.1.3. The present study 77
4.2. Materials and methods 78
4.2.1. Participants 78 4.2.2. VAST-Ru 79 4.2.2.1. Adaptation procedure 79 4.2.2.2. Materials 80 4.2.2.3. Tasks 80 4.2.2.4. Procedure 85 4.2.2.5. Scoring 86 4.2.2.6. Data analysis 86 4.3. Results 87
4.3.1. NBD and PWA VAST-Ru performance 87
4.3.2. Cluster analysis 88
4.3.3. Individual performance 92
4.4. Discussion 92
4.4.1. VAST-Ru as a method to assess verb and sentence impairment 92 4.4.2. Cluster analysis interpretation 92
4.4.3. Individual patterns 93
4.4.4. Verb and sentence impairments across aphasia types 94 4.4.5. Implications for research and clinical practice 95 4.4.6. Limitations and further directions 95
5. General discussion
975.1. A stimuli database of action pictures and verbs 98
5.2. Neural underpinnings of action naming 99
5.3. Verb processing and its relation to sentence processing in aphasia 100
5.4. Verb processing in aphasia – conclusions and further directions 101
5.5. Clinical implications 102
