University of Groningen
Endocytosis of nanomedicines Francia, Valentina
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Publication date: 2018
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Francia, V. (2018). Endocytosis of nanomedicines: Dissecting the pathways of uptake of nanosized drug carriers by cells. University of Groningen.
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STELLINGEN
behorende bij het proefschrift
1. Research on nanoparticle uptake and fate involves a combination of advanced chemistry and cutting edge cell biology. A close collaboration between scientists with different backgrounds is therefore essential for future research.
2. Drug delivery needs to become a discipline that embraces the cell biology of macromolecule uptake, and it needs to study more closely how viruses and bacterial toxins exploit the host trafficking machinery to gain access to intracellular targets. After all, these agents have spent a few million years finding out how to enter cells. (Editorial, Nature Biotechnology 2014).
3. The biological identity of nano-sized materials depends on their biomolecular corona, which determines their fate, cellular uptake and distribution. (This thesis)
4. The recognition between the LDLR (Low Density Lipoprotein Receptor) and the corona of silica nanoparticles depends on the amount and composition of the serum used to form the corona. (This thesis)
5. Curvature generation mechanisms play an important role in the uptake of nano-sized cargoes in cells (This thesis).
6. Studying in more detail how nano-sized materials interact with cells provides the basis for a more rational design of nanomedicines. (This thesis)
7. “Nothing in life is to be feared, it is only to be understood. Now is the time to understand more, so that we may fear less.” (Maria Skłodowska-Curie)
8. Science should be about proving yourself wrong and not about proving the others you are right. (about ‘Publish or perish’ in academia).
9. We should keep in mind that: “No amount of experimentation can ever prove me right; a single experiment can prove me wrong.” (Albert Einstein)
10. We should “put the philosophy back into the doctorate of philosophy” (Bosch, G., Nature 2018)
11. “La vita è fatta di cose reali e di cose supposte: se le reali le mettiamo da una parte, le supposte dove le mettiamo?” – “Life is made of real and alleged things: if we put aside the real ones, what should we do with the alleged ones?” (from italian comedy “Totò, Peppino e…la dolce vita”, 1961
