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Interactions between thyroid hormone and microRNAs in the heart:

Janssen, J.A.

2016

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citation for published version (APA)

Janssen, J. A. (2016). Interactions between thyroid hormone and microRNAs in the heart: implications for

pathological ventricular remodeling.

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Chapter 1

General Introduction

Part III A Evidence for a local hypothyroid condition — 24 Part III B Focus on DIO3 — 27

Aims and outline of the study — 29

Chapter 2

Thyroid hormone- regulated

cardiac microRNAs are

predicted to suppress

pathological hypertrophic

signaling

Abstract — 32 Introduction — 33

Materials and methods — 35 Results — 37

Discussion — 42

Supplementary data — 45

Chapter 3

Cardiac expression of

deiodinase type 3 (Dio3)

following myocardial

infarction is associated

with the induction of a

pluripotency microRNA

signature from the

Dlk1-Dio3 genomic region

Introduction — 51

Methods and methods — 52 Results — 54

Discussion — 57

Supplementary data — 59

Chapter 4

MicroRNA 214 is a

potential regulator of

thyroid hormone levels

in the mouse heart

following myocardial

infarction, by targeting

the thyroid- hormone

inactivating enzyme

deiodinase type III

Introduction — 65

Materials and methods — 67 Results — 71 Discussion — 77 Supplementary data — 80 Chapter 5

Cardiac induction of

the thyroid-hormone

degrading enzyme type III

deiodinase in human

ischemic heart failure

Introduction — 85

Methods and materials — 87 Results — 90

Discussion — 93

Chapter 6