Cover Page
The handle http://hdl.handle.net/1887/65995 holds various files of this Leiden University
dissertation.
Author: Blok, J.J.
Title: Predicting outcome after liver transplantation
Issue Date: 2018-09-18
Predicting outcome after
liver transplantation
Joris J. Blok
Colophon
Predicting outcome after liver transplantation Thesis, Leiden University, the Netherlands 2018 Joris J. Blok, 2018, the Netherlands
ISBN: 978-94-6361-125-1
Layout and printed by: Optima Grafische Communicatie (www.ogc.nl)
All rights reserved. No parts of this thesis may be reproduced, distributed, stored in a retrieval system or transmitted in any form or by any means, without prior written permission of the author.
Financial support by the Leiden University Medical Center (LUMC), Haaglanden Medical Center (HMC), Nederlandse Transplantatie Vereniging (NTV), Stichting Extracurriculaire Activiteiten Haagse Chirurgen (SEAHC), Astellas Pharma, Chiesi Pharmaceuticals, Bridge to Life and ChipSoft for the printing of this thesis is gratefully acknowledged.
The cover shows the painting ‘Liver Transplant’ by Sir Roy Y. Calne, depicting the `moment of truth’ when the replacement organ is being transplanted (will it ‘take’?). The diseased organ has been removed to foreground right. By the courtesy of the Science Museum, London.
Reproduced with permission by Sir Roy Y. Calne (personal communication).
Sir Roy Y. Calne, FRS, transplant surgeon and Professor Emeritus of Surgery at University of Cambridge, performed the first liver transplantation in Europe in 1968.
Predicting outcome after liver transplantation
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnificus prof. mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op dinsdag 18 september 2018
klokke 15.00 uur door Joris Jonathan Blok geboren te Leidschendam
in 1986
Promotor
Prof. dr. J.F. Hamming Copromotor Dr. A.E. Braat
Leden promotiecommissie Prof. dr. I.P.J. Alwayn Dr. M.J. Coenraad Prof. dr. B. van Hoek
Prof. dr. H.J. Metselaar (Erasmus Universiteit Rotterdam) Prof. dr. R.J. Porte (Universiteit Groningen)
Voor Josephine
COnTEnTS
Chapter 1 Introduction and outline of this thesis 9
Part I. Waitlist mortality and outcome after liver transplantation
Chapter 2 A decade of MELD-based liver allocation in Eurotransplant and its effect on liver transplant waitlist outcomes
21 Submitted
Part II. Donor risk factors and models in liver transplantation
Chapter 3 Validation of the donor risk index in orthotopic liver transplantation within the Eurotransplant region
43 Liver Transplantation 2012
Chapter 4 The Eurotransplant donor risk index in liver transplantation: ET-DRI 61 American Journal of Transplantation 2012
Chapter 5 Longterm results of liver transplantation from donation after circulatory death
77 Liver Transplantation 2016
Part III. Combining donor risk, recipient risk and the center effect
Chapter 6 The combined effect of donor and recipient risk on outcome after liver transplantation: research of the Eurotransplant database
95 Liver Transplantation 2015
Chapter 7 Identification and validation of the predictive capacity of risk factors and models in liver transplantation over time
111 Transplantation Direct 2018
Chapter 8 The center effect in liver transplantation in the Eurotransplant region – a retrospective database analysis
135 Transplant International 2018
Summary and general discussion
Chapter 9 Summary, general discussion and future perspectives 159
Chapter 10 Summary in Dutch (Nederlandse samenvatting) 181
Appendices
Abbreviations and definitions 192
List of publications 194
Curriculum vitae 197
Acknowledgements (Dankwoord) 198
