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The observed pattern of cnLOH versus physical loss was confirmed for five representative MAP carcinomas (t2, t4, t10, t12 and t18) after flow sorting, by FISH for chromosome 17p and

In the search for low risk factors we replicated the association of six loci, identified in large ge- nome-wide association studies, in a Dutch clinical-based cohort of 995 familial

Mitotic checkpoint genes hBUB1 and hBUBR1 have been described to contribute to chromosomal instability.[66,67] Tumor suppressor gene p53, involved in G1 arrest and apoptosis,

We processed the data according to the following work- flow: 1) First, the genotype data were generated by Gene- Chip DNA Analysis Software (GDAS) from Affymetrix. 2) These genotype

Second, we studied the genomic profiles of the tumors of affected family members to identify commonly altered genomic regions likely to harbor tumor suppressor genes.. Finally,

Overall, the ORs identified in our cohort tend to be increased compared with the ORs described in the initial genome-wide association studies, consistent with our series

The observed pattern of cnLOH versus physical loss was confirmed for five representative MAP carcinomas (t2, t4, t10, t12 and t18) after flow sorting, by FISH for chromosome 17p and

We compared the profile of aberrations in our MMR-proficient familial CRCs series to that of sporadic CRC, MAP carcinomas, and Lynch carcinomas series that we analyzed previously,