Iris and iridociliary melanoma : concepts in diagnosis and management
Razzaq, L.
Citation
Razzaq, L. (2011, October 11). Iris and iridociliary melanoma : concepts in diagnosis and management. Retrieved from
https://hdl.handle.net/1887/17921
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Iris and Iridociliary Melanoma
Concepts in Diagnosis and Management
Lubna Razzaq
The studies described in this thesis were performed at the Department of Ophthalmology of the Leiden University Medical Center, Leiden, the Netherlands.
Lay-out by: In Zicht Grafisch Ontwerp, Arnhem.
Printed by: Wöhrmann Print Service, Zutphen.
ISBN: 978-90-8570-861-2
Copyright © L. Razzaq, Leiden, the Netherlands. All rights reserved.
This research was funded by a Scholarship from the Higher Education Commission, Government of Pakistan. Research and travel grants were also provided by the Department of Ophthalmology LUMC, Stitching Blinden-Penning and Nelly Reef Fund.
Financial support to the costs associated with the publication of this thesis from Stichting Leids Oogheelkundig Ondersteunings Fonds (LOOF), Eckert & Ziegler BEBIG, MSD, Novartis, Allergan, Alcon, Thea and Carl-Zeiss are highly acknowledged.
Iris and Iridociliary Melanoma
Concepts in Diagnosis and Management
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof. mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op dinsdag 11 oktober 2011 klokke 16.15 uur
door
Lubna Razzaq
geboren te Islamabad, Pakistan in 1975
Promotiecommissie:
Promotors
Prof. Dr. G.P.M. Luyten Prof. Dr. R.J.W. de Keizer Overige leden
Prof. Dr. N. E. Schalij-Delfos
Prof. Dr. J.E.E. Keunen ( University Medical Center, St. Radboud, Nijmegen) Prof. Dr. B.E. Damato ( Royal Liverpool and Broadgreen University Hospital,
Liverpool, United Kingdom)
Dr. A.C. Moll (Vrije University Medical Center, Amsterdam)
The patient care is the center of the medical universe around which all our work resolves and towards which all our efforts tend.
J.B. Murphy (1857 – 1916)
Professor of surgery
Northwestern university, Chicago, USA
To honour my parents
With gratitude to my husband
With love to my sons
Contents
Chapter 1 General Introduction 9
PART 1 Diagnosis of iris and iridociliary melanoma
Chapter 2 Guidelines for diagnosis and treatment decision of suspected iris 33 and iridociliary melanomas based on clinical and
ultrasound biomicroscopic features
Chapter 3 Anterior segment imaging for iris melanocytic tumors 53 Chapter 4 Mesectodermal suprauveal iridociliary leiomyoma: Transscleral 67
excision without postoperative iris defect
PART II Surgical management of iris melanoma and correlation with histopathology
Chapter 5 Clinical and pathologic characteristics of biopsy proven iris 77 Melanoma: A Multicenter International Study
Chapter 6 Iris melanoma in a child treated with iridectomy and a phakic 97 iris repair implant lens: A case report of 8 years follow-up
PART III: Plaque brachytherapy for iris melanoma
Chapter 7 Ruthenium plaque radiation therapy for iris and iridociliary 107 melanomas
Chapter 8 Ruthenium plaque radiation for iris and iridociliary melanomas: 123 Development of dry eyes?
Chapter 9 Corneal endothelial cell density after ruthenium plaque radiation 131 therapy for iris melanoma patients
Chapter 10 Summary and general discussion 147
Nederlandse Samenvatting 159
Appendix 171
Acknowledgements 183
List of Publications 189
Curriculum Vitae 195
