Cover Page The handle http://hdl.handle.net/1887/137984 holds various files of this Leiden University dissertation. Author: Gravesteijn, G. Title: Preparing for CADASIL therapy Issue Date: 2020-10-28

At this point, I should also thank colleagues and staff at the Turkish Studies Department of Leiden University, the International Institute of Social History, which

The results derived from these textual and discursive practices will be identified in the hegemonic analysis of the two military intervention processes, with a special focus on the

The static character, theoretical limitations, and geographical dependency of Mardin’s center- periphery analysis are overcome by Gramscian hegemony’s analytical and theoretical depth

To validate whether serum Neurofilament Light-chain (NfL) levels correlate with disease severity in CADASIL, and to determine whether serum NfL predicts disease progression and

- Natural occurring NOTCH3 exon skipping is associated with reduced NOTCH3 protein aggregation in CADASIL patients, suggesting that cysteine corrected NOTCH3

Voor de verdere ontwikkeling van de NOTCH3 cysteïne correctie therapie, zijn binnen dit promotietraject ASOs toegediend aan CADASIL muizen om te testen of NOTCH3 exon

Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands; Department of Neurology, Leiden Univeristy Medical Center, Leiden, The Netherlands..

Mensen met een CADASIL mutatie resulterend in NOTCH3 cysteïne correctie hebben minder NOTCH3 aggregatie en een milder fenotype dan klassieke CADASIL patiënten.. De ontwikkelde