Costimulation blockade and regulatory T-cells in a non- human primate model of kidney allograft transplantation
Haanstra, K.G.
Citation
Haanstra, K. G. (2008, March 13). Costimulation blockade and regulatory T- cells in a non-human primate model of kidney allograft transplantation.
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Abbreviations
agm african green monkey
AICD activation induced cell death ATG anti-thymocyte globulin APC antigen presenting cell B7-H3, B7-H4 B7-homologue 3, 4
BPRC Biomedical Primate Research Centre
BSA bovine serum albumin
BTLA B and T lymphocyte attenuator CAN chronic allograft nephropathy CI calcineurin inhibitors
CMV cytomegalovirus
COS costimulation blockade
CsA Cyclosporin A
CTL cytotoxic T-lymphocyte
CTLA-4 Cytotoxic T-lymphocyte antigen-4
DC dendritic cell
DTH delayed type hypersensitivity
EBV Epstein Barr virus
Foxp3, FOXP3 mouse, human forkhead/winged-helix p3
GITR, GITRL glucocorticoid induced T-cell receptor, GITR ligand GVHD graft-versus-host disease
HLA Human Leukocyte Antigen
HVEM herpes virus entry mediator
i interstitial inflammation according to Banff criteria
i.m. intramuscular
i.v. intravenous
ICOS, ICOS-L inducible costimulator, ICOS-ligand
IFN-γ interferon-γ
IF/TA interstitial fibrosis and tubular athrophy IgG, IgM Immunoglobulin G, Ig M
IL-2, -4, -10, etc interleukin-2, -4, -10, etc
ILT-3, ILT-4 immunoglobulin-like transcript 3, 4
IPEX immunodysregulation, polyendocrinopathy, enteropathy X-linked syndrome
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Abbreviations
ISD immunosuppressive drugs
IVIG intravenous immunoglobulin LAP latency-associated peptide LTS monkeys long-term surviving monkeys
mAb monoclonal antibodies
MFI mean fluorescence intensity MHC Major Histocompatibility Complex
MLC, MLR mixed lymphocyte culture, mixed lymphocyte reaction
MMF mycophenolate mofetil
NF-κB nuclear factor-κB
NFAT nuclear factor of activated T-cells
NHP non-human primate(s)
NK-cell natural killer cell NKT cell natural killer T-cell
NOD non-obese diabetic
PBMC peripheral blood mononuclear cells PBS phosphate buffered saline
PD-1 programmed death-1
PD-L1, PD-L2 PD-ligand 1, PD-ligand 2
POD postoperative day
RACA rhesus anti-chimeric antibody
SI stimulation index
SIV simian immunodeficiency virus
SMAD7 mothers against decapentaplegic homologue 7 SCID severe combined immune deficiency
SPF specific pathogen-free
t tubulitis according to Banff criteria
TCR T-cell receptor
Teff effector T-cell
TGF-β transforming growth factor-β Th cell T-helper cell
TLR Toll-like receptor
TNF, TNFR tumour necrosis factor, TNF receptor Tr1 cell T regulatory type 1 cell
Treg regulatory T-cell
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