Radiotherapy in bone metastasis : the Dutch bone metastasis study Linden, Y.M. van der
9
0
0
Hele tekst
(2) %URO1OL A NEW FACILITY FOR THE MEASUREMENT OF HEALTH RELATED QUALITY OF LIFE 4HE %URO1OL 'ROUP (EALTH 0OLICY $OLAN 0 -ODELING VALUATIONS FOR %URO1OL (EALTH STATES -ED #ARE 'OLD -2
(3) 3IEGEL *%
(4) 2USSELL ,"
(5) 7IENSTEIN -# #OST EFFECTIVENESS IN HEALTH AND MEDICINE .EW 9ORK .9 /XFORD #ITY 0RESS
(6) /OSTENBRINK *"
(7) +OOPMANSCHAP -!
(8) 2UTTEN && -ANUAL FOR COST ANALYSES
(9) METHODS AND STANDARD PRICES FOR ECONOMIC EVALUATIONS IN HEALTH CARE IN $UTCH $UTCH (EALTH )NSURANCE %XECUTIVE "OARD
(10) EDITOR !MSTELVEEN 4HE .ETHERLANDS $UTCH (EALTH )NSURANCE %XECUTIVE "OARD 0HARMACOTHERAPEUTIC #OMPASS IN $UTCH $UTCH (EALTH )NSURANCE %XECUTIVE "OARD
(11) EDITOR !MSTELVEEN 4HE .ETHERLANDS VAN (OUT "!
(12) !L -*
(13) 'ORDON '3
(14) 2UTTEN && #OSTS
(15) EFFECTS AND #% RATIOS ALONGSIDE A CLINICAL TRIAL (EALTH %CON "RIGGS !(
(16) /"RIEN "*
(17) "LACKHOUSE ' 4HINKING OUTSIDE THE BOX RECENT ADVANCES IN THE ANALYSIS AND PRESENTATION OF UNCERTAINTY IN COST EFFECTIVENESS STUDIES !NNU 2EV 0UBLIC (EALTH 4HOMPSON 3'
(18) "ARBER *! (OW SHOULD COST DATA IN PRAGMATIC RANDOMISED TRIALS BE ANALYSED "-* %ARLE ##
(19) #HAPMAN 2(
(20) "AKER #3
(21) "ELL #-
(22) 3ONE 07
(23) 3ANDBERG %! 3YSTEMATIC OVERVIEW OF COST UTILITY ASSESSMENTS IN ONCOLOGY * #LIN /NCOL 3INGER 0!
(24) -ARTIN $+
(25) +ELNER - 1UALITY END OF LIFE CARE PATIENTS PERSEPCTIVES *!-! 4UBIANA -
(26) %SCHWEGE & #ONFORMAL RADIOTHERAPY AND INTENSITY MODULATED RADIOTHERAPY CLINICAL DATA !CTA /NCOL 3UIT ( 4HE 'RAY ,ECTURE COMING TECHNICAL ADVANCES IN RADIATION ONCOLOGY )NT * 2ADIAT /NCOL "IOL 0HYS "EN *OSEF %
(27) 3HAMSA &
(28) 7ILLIAMS !/
(29) 0ORTER !4 2ADIOTHERAPEUTIC MANAGEMENT OF OSSEOUS METASTASES A SURVEY OF CURRENT PATTERNS OF CARE )NT * 2ADIAT /NCOL "IOL 0HYS ,IEVENS 9
(30) 6AN DEN "7
(31) 2IJNDERS !
(32) +UTCHER '
(33) +ESTELOOT + 0ALLIATIVE RADIOTHERAPY PRACTICE WITHIN WESTERN EUROPEAN COUNTRIES IMPACT OF THE RADIOTHERAPY lNANCING SYSTEM 2ADIOTHER /NCOL $UTCH 3OCIETY FOR 2ADIOTHERAPY AND /NCOLOGY -ASTERPLAN ON RADIOTHERAPY CAPACITY SHORTAGE
(34) A SHARED CONCERN !MERSFOORT 4HE .ETHERLANDS
(35) $UTCH 3OCIETY FOR 2ADIOTHERAPY AND /NCOLOGY . $ISCUSSION AND FUTURE PERSPECTIVES.
(36) $ISCUSSION AND FUTURE PERSPECTIVES *OUIJTUIFTJT UIFSFTVMUTPGUIF%VUDI#POF.FUBTUBTJT4UVEZPOUIFUSFBUNFOU PGQBJOGVMCPOFNFUBTUBTFTJOQBUJFOUTBSFQSFTFOUFE5IFQVSQPTFPGUIJT USJBMXBTUPQSPWFUIFFRVBMFGGFDUJWFOFTTPGUXPQBMMJBUJWFSBEJPUIFSBQZUSFBU NFOUTDIFEVMFTBTJOHMFGSBDUJPOPG(ZWFSTVT(ZJOGSBDUJPOT 5IJTDIBQUFSBEESFTTFTUIFJNQMJDBUJPOTPGUIF%VUDI#POF.FUBTUBTJT4UVEZ BTXFMMBTCPOFNFUBTUBTJTSFMBUFEJTTVFTUIBUOFFEGVSUIFSJOWFTUJHBUJPO. -ETHODOLOGY )SSUES IN "ONE -ETASTASES 2ESEARCH .BKPSDSJUJDJTNJOCPOFNFUBTUBTFTSFTFBSDIIBTCFFOUIFIFUFSPHFOFJUZJOEFTJHO PGUIFQVCMJTIFESBOEPNJ[FEDMJOJDBMUSJBMTXJUIEJGGFSFOUFOEQPJOUEF¾OJUJPOT BOEWBSJPVTQBUJFOUQPQVMBUJPOT5IFSFGPSF JO BO*OUFSOBUJPOBM#POF.FUBT UBTFT$POTFOTVT8PSLJOH1BSUZXBTJOJUJBUFEJOPSEFSUPQSPNPUFDPOTJTUFODZJO FOEQPJOUEF¾OJUJPOTJOGVUVSFDMJOJDBMUSJBMTPOUIFUSFBUNFOUPGQBUJFOUTXJUI QBJOGVMCPOFNFUBTUBTFT5IJTJOUFSOBUJPOBMFGGPSUSFTVMUFEJOBXSJUUFODPOTFO TVTBOEBOPOHPJOHDMPTFDPPQFSBUJPOCFUXFFOEFEJDBUFESFTFBSDIFST1BSUJDJ QBOUTJOUIFDPOTFOTVT¾MMFEPVUTVSWFZTDPOUBJOJOHQSFGFSFODFTPOCPOFNFUBT UBTFTSFMBUFEJTTVFT BOEWJTJUFEUIFDPOTFOTVTNFFUJOHJO#PTUPO 64"JO0DUPCFS BUUIF"4530"OOVBM$POGFSFODF"NPOHPUIFST UIFDPOTFOTVTTUBUFEUIBU SFUSFBUNFOUTIPVMEOPUCFJODMVEFEJOUIFQSJNBSZPVUDPNFPGUIF¾STUJSSB EJBUJPO SFTQPOTFUPSFUSFBUNFOUTIPVMECFTFQBSBUFMZBOBMZ[FE BOEDIBOHFTJO BOBMHFTJDTJOUBLFTIPVMECFDPSSFDUFEGPSJOUIFSFTQPOTFDBMDVMBUJPOT 4PNFRVFTUJPOTSFHBSEJOHCPOFNFUBTUBTFTSFTFBSDIBSFTUJMMPQFOGPSEJT DVTTJPOBOEPSOFFENPSFSFTFBSDI 5JNJOHPGQBJOSFTQPOTFBTTFTTNFOU 3FTQPOTFDBOCFNFBTVSFEBU¾YFEUJNFQPJOUT JFBU BOENPOUIT BT XBTQSPNPUFEJOUIFDPOTFOTVT PSBTBSFTQPOTFPDDVSSJOHBUBOZUJNFEVSJOH GPMMPXVQ $SJUJDJTNUPUIFMBUUFSNFUIPEJTUIBUBSFTQPOTFPDDVSSJOHCFZPOE NPOUITNBZSF¿FDUTFDPOEBSZJOUFSWFOUJPOT TVDIBTBSFUSFBUNFOU DIBOHFT JOTZTUFNJDUIFSBQZPSBEKVTUNFOUTJOBOBMHFTJDTJOUBLF3FTQPOTFQFSDFOUBHFT NBZUIFOCFDPNFIJHIFS5IJTNFUIPE IPXFWFS EPFTSF¿FDUUIFSFTQPOTF QBUUFSOJOUJNF FTQFDJBMMZXIFOSFTQPOTFJTTIPXOHSBQIJDBMMZ*OUIF%#.4 XIJDIXBTEFTJHOFECFGPSFUIFDPOTFOTVTNFFUJOH XFDIPTFUPVTFUIFMBUUFS PGUIFUXPNFUIPET"MNPTUBMMSFTQPOTFTPDDVSSFEXJUIJOUIF¾STUNPOUIT BGUFSSBOEPNJ[BUJPO *OGVUVSF XFUIJOLSFQPSUJOHSFTQPOTFVTJOHCPUI NFUIPETXJMMHJWFUIFCFTUJOGPSNBUJPO *OEJWJEVBMQBJOSFTQPOTF -BSHFEJGGFSFODFTFYJTUJOSFTQPOTFQBUUFSOTCFUXFFOUIFJOEJWJEVBMQBUJFOUT.
(37) "GUFSQBMMJBUJWFUSFBUNFOU GPVSDBUFHPSJFTPGSFTQPOEFSTDBOCFQPJOUFEPVU JNNFEJBUFSFTQPOEFST XJUIJOBXFFL JOUFSNFEJBUFSFTQPOEFST XJUIJO XFFLT TMPXSFTQPOEFST XJUIJOXFFLT BOEOPSFTQPOEFST QFSTPOBMDPN NVOJDBUJPOXJUI+$WBO)PVXFMJOHFO &WFOXJUIJOUIFTBNFQSJNBSZUVNPST QBUJFOUTNBZSFTQPOEEJGGFSFOUMZ.PSFSFTFBSDIOFFETUPCFEPOFPOUIFDPVSTF PGQBJOEVSJOHBOEBGUFSUSFBUNFOUJOSFMBUJPOUPQBUJFOUµDIBSBDUFSJTUJDT &GGFDUTPGDPJOUFSWFOUJPOTPOQBJOSFMJFG "OPUIFSNPEVMBUJOHFGGFDUPOQBJOPUIFSUIBOSBEJPUIFSBQZJTUIFDPODPNJ UBOUVTFPGBOBMHFTJDTPSTZTUFNJDUSFBUNFOUT1BUJFOUTXJUICPOFNFUBTUBTFT PGUFOVTFBOBMHFTJDTXIFOSFGFSSFEGPSQBMMJBUJWFSBEJPUIFSBQZ"QQSPYJNBUFMZ PGUIFQBUJFOUTBMTPIBWFWJTDFSBMPSPUIFSNFUBTUBTFTBOESFRVJSFBNPSF TZTUFNJDUSFBUNFOUUPUSFBUUIFJSEJTFBTF*OUIF%.#4NPSFUIBOPGUIF QBUJFOUTSFDFJWFETPNFLJOEPGTZTUFNJDUIFSBQZDPODPNJUBOUMZ *UJTPCWJPVT UIBUDIBOHFTJOBOBMHFTJDTJOUBLFPSTZTUFNJDUIFSBQZNBZJO¿VFODFUIF QBJOFYQFSJFODFECZUIFQBUJFOUBOEDBOJOUFSGFSFXJUISFTQPOTFDBMDVMBUJPOT "MUIPVHIUIFDPOTFOTVTTUBUFEUIBUDIBOHFTJOBOBMHFTJDTJOUBLFTIPVMECF DPSSFDUFEGPS UIFQSFDJTFXBZJOXIJDIBMMUSFBUNFOUTJOUFSBDUJTVOLOPXO .PSFSFTFBSDIPOUSFBUNFOUJOUFSBDUJPOTJOSFMBUJPOUPSFQPSUFEQBJOOFFET UPCFQFSGPSNFE 2VBOUJGJDBUJPOPGSFTQPOTFEVSBUJPO "MUIPVHISFTQPOTFQFSDFOUBHFTPGUPUPQBMMJBUJWFSBEJPUIFSBQZGPS CPOFNFUBTUBTFTIBWFCFFOSFQPSUFE TUJMMBMBSHFQFSDFOUBHFPGUIFQBUJFOUT FYQFSJFODFTQSPHSFTTJWFQBJOBGUFSJOJUJBMUSFBUNFOU.PTUQVCMJTIFEUSJBMTSF QPSUFEQSPHSFTTJPOSBUFTCFUXFFOUPPGUIFQBUJFOUTXIPSFTQPOEFEUP JOJUJBMSBEJPUIFSBQZ 5IFTFQBUJFOUTOFFEBTFDPOEJSSBEJBUJPOPSPUIFSUSFBU NFOUNPEBMJUJFT5IVT SFQPSUJOHPOMZSFTQPOTFQFSDFOUBHFTEPFTOPUSF¿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o VAN DER ,INDEN
(38) (OLLAND (ARTSELL
(39) 53! 2OOS
(40) !USTRALIA.EW :EALAND +IRKBRIDE
(41) #ANADA "ONE 0AIN 4RIAL 7ORKING 0ARTY
(42) 5+.EW :EALAND 3TEENLAND
(43) (OLLAND +OSWIG
(44) 'ERMANY .IELSEN
(45) $ENMARK 'AZE
(46) 5+ +AGEI
(47) *APAN #OLE
(48) 5+ 0RICE
(49) 5+. 9EAR . 4REATMENT ARMS. 0ATIENTS 2 !. 'Y 3& VS
(50) 'Y &. 'Y 3& VS 'Y & 'Y 3& VS 'Y &. .3 . 'Y 3& VS 'Y & 'Y 3& VS 'Y &. . 'Y 3& VS 'Y & 'Y 3& VS 'Y & 'Y 3& VS 'Y & 'Y 3& VS 'Y & 3& VS -& 'Y 3& VS 'Y & 'Y 3& VS 'Y &. . !NALYSIS REVIEWED BY. 7U 7U. 7U 7U 7U
(51) 2ATANATHARATHORN
(52) -C1UAY 7U
(53) 2ATANATHARATHORN
(54) -C1UAY 2ATANATHARATHORN
(55) -C1UAY 7U
(56) 2ATANATHARATHORN
(57) -C1UAY 7U
(58) 2ATANATHARATHORN
(59) "EN *OZEF
(60) -C. 4RIALS COMPARING DIFFERENT MULTIPLE FRACTION REGIMENS !UTHORCOUNTRY .IEWALD
(61) 'ERMANY 2ASMUSSON
(62) $ENMARK (IROKAWA
(63) *APAN /KAWA
(64) *APAN. 9EAR. "LITZER
(65) 53!p -ADSEN
(66) $ENMARK 4ONG
(67) 53!. . !UTHORCOUNTRY *EREMIC
(68) 9UGOSLAVIA (OSKIN
(69) 5+. . 9EAR. 4REATMENT ARMS. 0ATIENTS 2 !. !NALYSIS REVIEWED BY. 'Y & VS 'Y & 7U
(70) 2ATANATHARATHORN
(71) -C1UAY 7U
(72) 2ATANATHARATHORN
(73) -C1UAY 'Y & VS 'Y & 'Y & VS 'Y & 7U
(74) -C1UAY 'Y & BID VS 7U
(75) 2ATANATHARATHORN
(76) "EN *OZEF
(77) -C 'Y & VS 'Y &. 7U
(78) 2ATANATHARATHORN
(79) "EN *OZEF
(80) -C 'Y & VS 'Y & 3OLITARY METASTASIS 7U
(81) 2ATANATHARATHORN
(82) "EN *OZEF
(83) -C 'Y & VS 'Y & -ULTIPLE METASTASES 'Y & VS 'Y &
(84) VS 'Y & VS 'Y & 4RIALS COMPARING DIFFERENT SINGLE FRACTION REGIMENS 4REATMENT ARMS 'Y VS 'Y VS 'Y 'Y VS 'Y. 0ATIENTS 2 ! . !NALYSIS REVIEWED BY. 7U
(85) 2ATANATHARATHORN 7U
(86) 2ATANATHARATHORN
(87) "EN *OZEF
(88) -C. 2 NUMBER OF PATIENTS RANDOMIZED
(89) ! NUMBER OF PATIENTS ASSESSABLE FOR RESPONSE CALCULATIONS .3 NOT STATED o 4HIS PUBLICATION WAS A FURTHER ANALYSIS OF THE $UTCH "ONE -ETASTASIS 3TUDY BY 3TEENLAND ET AL
(90) CORRECTING FOR THE INm UENC AND CHANGES IN ANALGESICS INTAKE p 4HIS PUBLICATION WAS A REANALYSIS OF THE 24/' TRIAL BY 4ONG ET AL .
(91) FG¾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¾OJUJWFSFTVMUTPOEVSBCJMJUZPGSFTQPOTFJOUIJTUSJBMIBWFUPCFBXBJUFEGPS 3FDFOUMZ 'PSP"SOBMPUFUBMSFQPSUFEBUUIF&4530NFFUJOHPOUIFFRVBM FGGFDUJWFOFTTPG(ZTJOHMFGSBDUJPOWT(ZJOGSBDUJPOTJOQBUJFOUT &BSMZSFTVMUTPGUIFMBTUPOHPJOH"VTUSBMJBOUSJBM530(GPSOFVSPQBUIJD QBJO JFQBJOXJUIBSBEJBUJOHDVUBOFPVTDPNQPOFOUEVFUPDPNQSFTTJPOPS JSSJUBUJPOPGOFSWFTCZUVNPS SFQPSUFEFGGFDUJWFOFTTPGSBEJPUIFSBQZJO BGUFS(Z4'BOE(Z.'SBEJPUIFSBQZ 5IF¾OBMSFTVMUTXJMMCFQSFTFOUFE JOUIFOFBSGVUVSF #ZOPX XFUIJOLUIFSBEJPUIFSBQZDPNNVOJUZXJMMIBWFUPDPODMVEFUIBU UIFMJUFSBUVSFPOUIFFRVBMFGGFDUJWFOFTTPGBTJOHMFEPTFTDIFEVMFWFSTVTNPSF QSPUSBDUFESFHJNFOTGPSUIFNBKPSJUZPGQBUJFOUTXJUIQBJOGVMCPOFNFUBTUBTFT JTPWFSXIFMNJOH . 52% . &)'52% . -ETA ANALYSIS OF COMPLETE RESPONSE RATES FROM RANDOMIZED TRIALS OF SINGLE VS MULTIPLE FRACTIONS OF 24 FOR PAINFUL BONE METASTASES INTENTION TO TREAT N NUMBER OF PATIENTS ACHIEVING COMPLETE RESPONSE . NUMBER OF PATIENTS RANDOMIZED. A 3ENSITIVITY ANALYSIS USING ASSESSABLE PATIENTS AS DENOMINATORS FOR COMPLETE RESPONSE RATES
(92) SINGLE VS MULTIPLE FRACTIONS N NUMBER OF PATIENTS ACHIEVING A COMPLETE RESPONSE . NUMBER OF PATIENTS ASSESSABLE. DY. ADIAN E 0AIN 4RIAL CH WIG SEN E E . L #). 3INGLE N(. -ULTIPLE N(. . .
(93)
(94)
(95)
(96)
(97)
(98)
(99) . . .
(100) . 22 #) 2ANDOM. 22 #) 2ANDOM. FOR HETEROGEINITY CHI SQUARE DF P FOR OVERAL EFFECT Z P . ADIAN E 0AIN 4RIAL CH SEN WIG E E . L #). -ULTIPLE N(. #ANADIAN "ONE 0AIN 4RIAL $UTCH .IELSEN +OSWIG 'AZE 0RICE . . .
(101)
(102)
(103)
(104)
(105)
(106)
(107) . 4OTAL #). . .
(108) . 22 #) 2ANDOM. 22 #) 2ANDOM. 4EST FOR HETEROGEINITY CHI SQUARE DF P 4EST FOR OVERAL EFFECT Z P &AVORS MULTIPLE &AVORS SINGLE. &AVORS MULTIPLE &AVORS SINGLE. -ETA ANALYSIS OF OVERALL RESPONSE RATES FROM RANDOMIZED TRIALS OF SINGLE VS MULTIPLE FRACTIONS OF 24 IN PAINFUL BONE METASTASES INTENTION TO TREAT N NUMBER OF PATIENTS ACHIEVING COMPLETE OR PARTIAL RESPONSE . NUMBER OF PATIENTS RANDOMIZED. DY. 3INGLE N(. 3TUDY. 3INGLE N(. -ULTIPLE N(. . .
(109)
(110)
(111)
(112)
(113)
(114)
(115)
(116) . . .
(117) . 22 #) 2ANDOM. FOR HETEROGEINITY CHI SQUARE DF P FOR OVERAL EFFECT Z P . 22 #) 2ANDOM. B 3ENSITIVITY ANALYSIS USING ASSESSABLE PATIENTS AS DENOMINATORS FOR OVERALL RESPONSE RATES
(118) SINGLE VS MULTIPLE FRACTIONS N NUM OF PATIENTS ACHIEVING OVERALL RESPONSE . NUMBER OF PATIENTS ASSESSABLE 3TUDY #ANADIAN "ONE 0AIN 4RIAL $UTCH .IELSEN +OSWIG 'AZE #OLE 0RICE 4OTAL #). 3INGLE N(. -ULTIPLE N(. . .
(119)
(120)
(121)
(122)
(123)
(124)
(125)
(126) . . .
(127) . 22 #) 2ANDOM. 4EST FOR HETEROGEINITY CHI SQUARE DF P 4EST FOR OVERAL EFFECT Z P &AVORS MULTIPLE &AVORS SINGLE. &AVORS MULTIPLE &AVORS SINGLE. 22 #) 2ANDOM.
(128) )MPLEMENTATION OF THE SINGLE DOSE SCHEDULE FOR PAINFUL BONE METASTASES 0OFDPVMEBSHVFUIBUTJOHMFGSBDUJPOSBEJPUIFSBQZXPVMECZOPXIBWF CFDPNFUIFTUBOEBSEUIFSBQZJOUIFXPSME CVUVOGPSUVOBUFMZUIJTJTOPUUIF DBTF*ODIBQUFS BOFEJUPSJBMJTQSFTFOUFEDPODFSOJOHUIJTUPQJD#FTJEFT DMJOJDBMBSHVNFOUT TPDJPFDPOPNJDGBDUPSTBMTPBGGFDUUIFDIPJDFGPSB TQFDJ¾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¿VFODFPGBSFUSFBUNFOUPOUIFJOJUJBMSFTQPOTFDBMDVMBUJPOT BOEJODPS QPSBUJOHQPTTJCMFDIBOHFTJOBOBMHFTJDTJOUBLF8FTIPXFEUIBUSFTQPOTFQFS DFOUBHFTCFUXFFOCPUIUSFBUNFOUTDIFEVMFTXFSFFRVBMFWFOXJUIUIFFGGFDUPG BSFUSFBUNFOUFYDMVEFEGSPNUIFSFTQPOTFDBMDVMBUJPOT*OBEEJUJPO XFEFNPO TUSBUFEUIBUQIZTJDJBOTXFSFNPSFXJMMJOHUPSFUSFBUBQBUJFOUJGUIFJOJUJBMUSFBU NFOUXBTB4'#FDBVTFUIFQVCMJTIFEUSJBMTEJEOPUJODMVEFQSPUPDPMHVJEFMJOFT GPSSFUSFBUNFOU UIFIJHIFSSFUSFBUNFOUQFSDFOUBHFTBGUFSB4'SFQPSUFEJOUIF MJUFSBUVSFXFSFCJBTFE 5PBOTXFSBMMPVUTUBOEJOHRVFTUJPOTPOSFUSFBUNFOU UIF¾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¿VFODFPGMFTJPOBMDIBSBDUFSJTUJDTBOESBEJP UIFSBQZUPUBMEPTFJOQBUJFOUTXJUIGFNPSBMMFTJPOT5IFPOMZMFTJPOBMDIBSBDUFS JTUJDQSFEJDUJWFGPSGSBDUVSJOHXBTUIFBYJBMDPSUJDBMJOWPMWFNFOUPGUIFMFTJPO XJUIBDVUPGGQPJOUBUNN'PSMFTJPOTXJUIBOBYJBMDPSUJDBMJOWPMWFNFOU. &)'52% $ECISION TREE FOR THE TREATMENT OF PATIENTS WITH PAINFUL BONE METASTASES OF THE FEMUR 0AINFUL FEMORAL BONE METASTASIS. -ULTIDIRECTIONAL 8 RAYS !XIAL CORTICAL INVOLVEMENT MM. !XIAL CORTICAL INVOLVEMENT ) MM. 3& RADIOTHERAPY 0AIN RESPONSE. 0AIN WORSE OR RECURRENT. #ONDITION ACCEPTABLE. #ONDITION WORSE. 0ROPHYLACTIC SURGERY. &OLLOW UP 0OSTOPERATI VE -& RADIOTHERAPY. -& RADIOTHERAPY.
(129) TNBMMFSUIBONNB4'XBTBTTBGFBTNVMUJQMFGSBDUJPOT8FUIFSFGPSFQSP QPTFBEFDJTJPOUSFFGPSUIFUSFBUNFOUPGGFNPSBMMFTJPOT ¾HVSF "MUIPVHI BQQMJDBUJPOPGUIJTEFDJTJPOUSFFXJMMMFBEUPBDFSUBJOEFHSFFPGTVSHJDBMPWFS USFBUNFOU UIFNPSCJEJUZPGTVTUBJOJOHBQBUIPMPHJDBMGSBDUVSFJTDPOTJEFSFE WFSZUSBVNBUJDGPSUIFQBUJFOU 'SPNBOFDPOPNJDQFSTQFDUJWF QBUIPMPHJDBM GSBDUVSJOHJTDPTUMZ BSFDFOUTUVEZTIPXFEIJHIEJSFDUDPTUTJOPMEFSXPNFO XIPGSBDUVSFEBCPOF .PTUQSPHOPTUJDGBDUPSTUPTFMFDUJNQFOEJOHMFTJPOT JODMVEJOHUIFBYJBM DPSUJDBMJOWPMWFNFOUPGUIFMFTJPO IBWFPOMZMJNJUFEQPTJUJWFQSFEJDUJWFWBMVFT BOEMFBEUPTVSHJDBMPWFSUSFBUNFOU DIBQUFS 3FTFBSDIJOPSEFSUPSF¾OF UIFTFQSPHOPTUJDGBDUPSTGPSGSBDUVSJOHJTOFDFTTBSZ CFDBVTFUIFQPUFOUJBM CFOF¾UPGBOJOUFSWFOUJPOJOUIJTJODSFBTJOHQBUJFOUQPQVMBUJPOJTQSPNJTJOH *OUIF/FUIFSMBOET BSFTFBSDIQSPQPTBMPOGSBDUVSFSJTLTVUJMJ[JOHQBUJFOU TQFDJ¾DDPNQVUFSNPEFMT 'JOJUF&MFNFOU.PEFMT CBTFEPOQSPTQFDUJWFMZ QBUJFOUEFSJWFEJOGPSNBUJPOPOEBJMZBDUJWJUJFTBOESFQFUJUJWF$5TDBOOJOHJT DVSSFOUMZCFJOHEFWFMPQFE 4QJOBMNFUBTUBTFT *ODIBQUFS XFTIPXFEUIBUQBUJFOUTXJUI)BSSJOHUPOµT$MBTT*BOE**TQJOBM NFUBTUBTFT CFOF¾UGSPN(ZTJOHMFGSBDUJPOSBEJPUIFSBQZ"OPUIFSSFMBUJWFMZ VODPNNPOUSFBUNFOUNPEBMJUZGPSQBJOGVMTQJOBMNFUBTUBTFTJTWFSUFCSP QMBTUZ JFJOKFDUJPOPGUIFMFTJPOXJUIQPMZNFUIZMNFUIBDSZMBUFUPTUSFOHUIFO UIFWFSUFCSB*OUIF/FUIFSMBOET BQSPTQFDUJWFMZSBOEPNJ[FETUVEZJTVOEFS DPOTUSVDUJPOUIBUXJMMTUVEZUIFQBMMJBUJWFFGGFDUPGWFSUFCSPQMBTUZWFSTVTSBEJP UIFSBQZJOQBUJFOUTXJUI)BSSJOHUPOµ$MBTT*BOE**MFTJPOT 'PSQBUJFOUTXJUI)BSSJOHUPOµ$MBTT***MFTJPOT UIFSFTVMUTPGBUSJBMXFSF SFQPSUFEBUUIF"4530BOOVBMNFFUJOHJOXIJDIQBUJFOUTXJUI TQJOBMDPSEDPNQSFTTJPOXFSFSBOEPNJ[FECFUXFFOEFDPNQSFTTJWFTVSHFSZ GPMMPXFECZSBEJPUIFSBQZPSSBEJPUIFSBQZBMPOF "GUFSBOJOUFSJNBOBMZTJT UIFTUPQQJOHSVMFXBTNFUCFDBVTFOFVSPMPHJDBMPVUDPNFXBTJOGBWPVSPGUIF TVSHFSZBSN1BUJFOUTUSFBUFEXJUITVSHFSZ
(130) SBEJPUIFSBQZSFUBJOFEUIFBCJMJUZ UPXBMLTJHOJ¾DBOUMZMPOHFSUIBOUIPTFUSFBUFEXJUI35BMPOF NFEJBO EBZTWTEBZT 1 "MUIPVHIUIFGVMMQBQFSJTOPUZFUQVCMJTIFE BEKVTUNFOUPGUIFQSJNBSZDBSFGPSUIFTFQBUJFOUTOFFETUPCFEJTDVTTFE CFUXFFOBMMPODPMPHJTUTJOWPMWFE XJUIQSPCBCMZBMBSHFSSPMFGPSEFDPNQSFT TJWFTVSHFSZ'PSQBUJFOUTXJUI)BSSJOHUPOµ$MBTT***MFTJPOTBOEBMPXQFSGPS NBODFTUBUVT BOEPSTIPSUMJGFFYQFDUBODZ BOJOUFSJNBOBMZTJTPGBSBOEPN J[FESBEJPUIFSBQZUSJBMPOIZQPGSBDUJPOBUJPOXBTSFDFOUMZQSFTFOUFEBU&4530 1BUJFOUTXFSFSBOEPNJ[FECFUXFFO(Z4'PSGSBDUJPOTPG(Z *O QBUJFOUTOPEJGGFSFODFTJOSFTQPOTFPSUPYJDJUZXFSFTFFO XJUISFMJFGPGCBDL QBJOJO BCJMJUZUPXBMLJO BOEHPPECMBEEFSGVODUJPOJOPGUIF. QBUJFOUT5IF¾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¾DFOPVHIUPEFUFDUTVCUMFEJGGFSFODFT-PDBM SBEJPUIFSBQZNBZJNQSPWFBDUJWJUJFTPGEBJMZMJWJOHUIBUBSFIBNQFSFECZ CPOFQBJO CVUOPUJNQSPWFPWFSBMMRVBMJUZPGMJGFJOQBUJFOUTCVSEFOFEXJUIB TZTUFNJDEJTFBTF"TQFDJ¾DCPOFNFUBTUBTFTNPEVMFPOQBUJFOUEF¾OFEBDUJWJUZ JOUFSGFSFODFUPBDDPNQBOZUIF&035$2-2$RVFTUJPOOBJSFGPSGVUVSFDMJOJDBM USJBMTJOQBUJFOUTXJUICPOFNFUBTUBTFTJTDVSSFOUMZVOEFSEFWFMPQNFOU &INAL CONCLUSION 5IFPVUDPNFPGUIF%VUDI#POF.FUBTUBTJT4UVEZDMFBSMZTIPXTUIBUBTJOHMF GSBDUJPOPG(ZJTBTFGGFDUJWFBT(ZJOGSBDUJPOTJOUSFBUJOHQBJOGVMCPOF NFUBTUBTFTGSPNTPMJEUVNPST"TJOHMFGSBDUJPOPG(ZTIPVMECFUIFTUBOEBSE UIFSBQZGPSUIFWBTUNBKPSJUZPGQBUJFOUTXJUIQBJOGVMCPOFNFUBTUBTFT . 2EFERENCE ,IST. #HOW %
(131) 7U *
(132) (OSKIN 0
(133) #OIA ,
(134) "ENTZEN 3
(135) "LITZER 0 )NTERNATIONAL CONSENSUS ON PALLIATIVE RADIOTHERAPY ENDPOINTS FOR FUTURE CLINICAL TRIALS IN BONE METASTASES 2ADIOTHER /NCOL 3TEENLAND %
(136) ,EER *7
(137) VAN (OUWELINGEN (
(138) 0OST 7*
(139) VAN DEN (OUT 7"
(140) +IEVIT * ET AL 4HE EFFECT OF A SINGLE FRACTION COMPARED TO MULTIPLE FRACTIONS ON PAINFUL BONE METASTASES A GLOBAL ANALYSIS OF $UTCH "ONE -ETASTASIS 3TUDY 2ADIOTHER /NCOL 2ATANATHARATHORN 6
(141) 0OWERS 7%
(142) -OSS 74
(143) 0EREZ #! "ONE METASTASIS REVIEW AND CRITICAL ANALYSIS OF RANDOM ALLOCATION TRIALS OF LOCAL lELD TREATMENT ;SEE COMMENTS= )NT * 2ADIAT /NCOL "IOL 0HYS .
(144) &ORO !RNALOT 0
(145) !LGARA -
(146) 6ALLS !
(147) &ERRER &
(148) 3ANZ 8
(149) 2ODRIGUEZ . ET AL 2ANDOMIZED CLINICAL TRIAL COMPARING TWO SCHEDULES OF BONE METASTASES TREATMENT 'Y MULTIFRACTION VS 'Y SINGLE FRACTION 2ADIOTHER /NCOL 3UPPL 3 "EN *OSEF %
(150) 3HAMSA &
(151) 9OUSSEF %
(152) 0ORTER !4 %XTERNAL BEAM RADIOTHERAPY FOR PAINFUL OSSEOUS METASTASES POOLED DATA DOSE RESPONSE ANALYSIS )NT * 2ADIAT /NCOL "IOL 0HYS -C1UAY (*
(153) #OLLINS 3,
(154) #ARROLL $ 2ADIOTHERAPY FOR THE PALLIATION OF PAINFUL BONE METASTASES #OCHRANE REVIEW 4HE #OCHRANE ,IBRARY )SSUE 'Y SINGLE FRACTION RADIOTHERAPY FOR THE TREATMENT OF METASTATIC SKELETAL PAIN RANDOMISED COMPARISON WITH A MULTIFRACTION SCHEDULE OVER MONTHS OF PATIENT FOLLOW UP "ONE 0AIN 4RIAL 7ORKING 0ARTY 2ADIOTHER /NCOL +OSWIG 3
(155) "UDACH 6 ;2EMINERALIZATION AND PAIN RELIEF IN BONE METASTASES AFTER AFTER DIFFERENT RADIOTHERAPY FRACTIONS TIMES 'Y VS TIME 'Y ! PROSPECTIVE STUDY= 3TRAHLENTHER /NKOL +IRKBRIDE 0
(156) 7ARDE 0
(157) 0ANZARELLA ! ! RANDOMISED TRIAL COMPARING THE EFlCACY OF SINGLE FRACTION RADIATION THERAPY PLUS ONDANSETRON WITH FRACTIONATED RADIATION THERAPY IN THE PALLIATION OF SKELETAL METASTASES !BSTRACT )NT * 2ADIAT /NCOL "IOL 0HYS 3UPPL 7U *3
(158) 7ONG 2
(159) *OHNSTON -
(160) "EZJAK !
(161) 7HELAN 4 -ETA ANALYSIS OF DOSE FRACTIONATION RADIOTHERAPY TRIALS FOR THE PALLIATION OF PAINFUL BONE METASTASES )NT * 2ADIAT /NCOL "IOL 0HYS 3ZE 7-
(162) 3HELLEY -$
(163) (ELD )
(164) 7ILT 4*
(165) -ASON -$ 0ALLIATION OF METASTATIC BONE PAIN SINGLE FRACTION VERSUS MULIFRACTION RADIOTHERAPY ! SYSTEMATIC REVIEW OF RANDOMISED TRIALS #LIN /NCOL 2 #OLL 2ADIOL (ARTSELL 7&
(166) 3COTT #
(167) "RUNER $7
(168) 3CARANTINO #7
(169) )VKER 2
(170) 2OACH - ET AL 0HASE ))) RANDOMIZED TRIAL OF 'Y IN FRACTION VS 'Y IN FRACTIONS FOR PALLIATION OF PAINFUL BONEMETASTASES PRELIMINARY RESULTS OF 24/' )NT * 2ADIAT /NCOL "IOL 0HYS 3UPPL 3 2OOS $%
(171) /"RIEN 0#
(172) 3MITH *'
(173) 3PRY .!
(174) (OSKIN 0*
(175) "URMEISTER "( ET AL ! ROLE FOR RADIOTHERAPY IN NEUROPATHIC BONE PAIN PRELIMINARY RESPONSE RATES FROM A PROSPECTIVE TRIAL 4RANS TASMAN RADIATION ONCOLOGY GROUP
(176) 42/' ;PUBLISHED ERRATUM APPEARS IN )NT * 2ADIAT /NCOL "IOL 0HYS -AY = )NT * 2ADIAT /NCOL "IOL 0HYS .IELSEN /3 0ALLIATIVE RADIOTHERAPY OF BONE METASTASES THERE IS NOW EVIDENCE FOR THE USE OF SINGLE FRACTIONS ;EDITORIAL COMMENT= 2ADIOTHER /NCOL #HOW %
(177) ,UTZ 3
(178) "EYENE * ! SINGLE FRACTION FOR ALL
(179) OR AN ARGUMENT FOR FRACTIONATION TAILORED TO lT THE NEEDS OF EACH INDIVIDUAL PATIENT WITH BONE METASTASES )NT * 2ADIAT /NCOL "IOL 0HYS "EN *OSEF %
(180) 3HAMSA &
(181) 7ILLIAMS !/
(182) 0ORTER !4 2ADIOTHERAPEUTIC MANAGEMENT OF OSSEOUS METASTASES A SURVEY OF CURRENT PATTERNS OF CARE )NT * 2ADIAT /NCOL "IOL 0HYS 2OOS $% #ONTINUING RELUCTANCE TO USE SINGLE FRACTIONS OF RADIOTHERAPY FOR METASTATIC BONE PAIN AN AUSTRALIAN AND NEW ZEALAND PRACTICE SURVEY AND LITERATURE REVIEW 2ADIOTHER /NCOL #HOW %
(183) $ANJOUX #
(184) 7ONG 2
(185) 3ZUMACHER %
(186) &RANSSEN %
(187) &UNG + ET AL 0ALLIATION OF BONE METASTASES A SURVEY OF PATTERNS OF PRACTICE AMONG CANADIAN RADIATION ONCOLOGISTS 2ADIOTHER /NCOL ,IEVENS 9
(188) +ESTELOOT +
(189) 2IJNDERS !
(190) +UTCHER '
(191) 6AN DEN "7 $IFFERENCES IN PALLIATIVE RADIOTHERAPY FOR BONE METASTASES WITHIN WESTERN EUROPEAN COUNTRIES 2ADIOTHER /NCOL ,IEVENS 9
(192) 6AN DEN "7
(193) 2IJNDERS !
(194) +UTCHER '
(195) +ESTELOOT + 0ALLIATIVE RADIOTHERAPY PRACTICE WITHIN WESTERN EUROPEAN COUNTRIES IMPACT OF THE RADIOTHERAPY lNANCING SYSTEM 2ADIOTHER /NCOL 3HAKESPEARE 40
(196) ,U **
(197) "ACK -&
(198) ,IANG 3
(199) -UKHERJEE 2+
(200) 7YNNE #* 0ATIENT PREFERENCE FOR RADIOTHERAPY FRACTIONATION SCHEDULE IN THE PALLIATION OF PAINFUL BONE METASTASES * #LIN /NCOL . 3PRINGlELD $3 0ATHOLOGIC &RACTURES &RACTURES IN !DULTS 2OCKWOOD 'REEN ,IPPINCOTT 7ILLIAMS 7ILKINS
(201) :HOU :
(202) 2EDAELLI !
(203) *OHNELL /
(204) 7ILLKE 2*
(205) -ASSIMINI ' ! RETROSPECTIVE ANALYSIS OF HEALTH CARE COSTS FOR BONE FRACTURES IN WOMEN WITH EARLY STAGE BREAST CARCINOMA #ANCER (ARRINGTON +$ -ETASTATIC DISEASE OF THE SPINE * "ONE *OINT 3URG !M 2EGINE 7&
(206) 4IBBS 0!
(207) 9OUNG !
(208) 0AYNE 2
(209) 3ARIS 3
(210) +RYSCIO 2* ET AL -ETASTATIC SPINAL CORD COMPRESSION A RANDOMIZED TRIAL OF DIRECT DECOMPRESSIVE SURGICAL RESECTION PLUS RADIOTHERAPY VS RADIOTHERAPY ALONE )NT * 2ADIAT /NCOL "IOL 0HYS 3UPPL 4RIPPA &
(211) -ARANZANO %
(212) 2OSSI 2
(213) ,UPATELLI -
(214) "ELLAVITA 2
(215) &RATTEGIANI ! ET AL 0HASE ))) RANDOMIZED CLINICAL TRIAL OF TWO DIFFERENT HYPOFRACTIONATED RADIOTHERAPY SCHEDULES 'Y X VS 'Y IN METASTATIC SPINAL CORD COMPRESSION !N INTERIM ANALYSIS 2ADIOTHER /NCOL 3UPPL 3 -ILKER :ABEL 3
(216) :ABEL !
(217) 4HILMANN #
(218) 3CHLEGEL 7
(219) 7ANNENMACHER -
(220) $EBUS * #LINICAL RESULTS OF RETREATMENT OF VERTEBRAL BONE METASTASES BY STEREOTACTIC CONFORMAL RADIOTHERAPY AND INTENSITY MODULATED RADIOTHERAPY )NT * 2ADIAT /NCOL "IOL 0HYS +AASA 3
(221) ,OGE *( 1UALITY OF LIFE ASSESSMENT IN PALLIATIVE CARE ,ANCET /NCOLOGY !ARONSON .+
(222) !HMEDZAI 3
(223) "ERGMAN "
(224) "ULLINGER -
(225) #ULL !
(226) $UEZ .* ET AL 4HE %UROPEAN /RGANIZATION FOR 2ESEARCH AND 4REATMENT OF #ANCER 1,1 # A QUALITY OF LIFE INSTRUMENT FOR U IN INTERNATIONAL CLINICAL TRIALS IN ONCOLOGY * .ATL #ANCER )NST DE (AES *#
(227) VAN +NIPPENBERG &#
(228) .EIJT *0 -EASURING PSYCHOLOGICAL AND PHYSICAL DISTRESS IN CANCER PATIENTS STRUCTURE AND APPLICATION OF THE 2OTTERDAM 3YMPTOM #HECKLIST "R * #ANCER %URO1OL A NEW FACILITY FOR THE MEASUREMENT OF HEALTH RELATED QUALITY OF LIFE 4HE %URO1OL 'ROUP ;SEE COMMENTS= (EALTH 0OLICY VAN DER ,INDEN 9-
(229) ,OK **
(230) 3TEENLAND %
(231) -ARTIJN (
(232) (OUWELINGEN *#
(233) ,EER *7( ET AL 3INGLE FRACTION RADIOTHERAPY IS EFlCACIOUS A FURTHER ANALYSIS OF THE $UTCH "ONE -ETASTASIS 3TUDY CONTROLLING FO THE INmUENCE OF RETREATMENT )NT * 2ADIAT /NCOL "IOL 0HYS +OSWIG 3
(234) "UDACH 6 ;2EMINERALIZATION AND PAIN RELIEF IN BONE METASTASES AFTER AFTER DIFFERENT RADIOTHERAPY FRACTIONS TIMES 'Y VS TIME 'Y ! PROSPECTIVE STUDY= 3TRAHLENTHER /NKOL .IELSEN /3
(235) "ENTZEN 3-
(236) 3ANDBERG %
(237) 'ADEBERG ##
(238) 4IMOTHY !2 2ANDOMIZED TRIAL OF SINGLE DOSE VERSUS FRACTIONATED PALLIATIVE RADIOTHERAPY OF BONE METASTASES 2ADIOTHER /NCOL 'AZE -.
(239) +ELLY #'
(240) +ERR '2
(241) #ULL !
(242) #OWIE 6*
(243) 'REGOR ! ET AL 0AIN RELIEF AND QUALITY OF LIFE FOLLOWING RADIOTHERAPY FOR BONE METASTASES A RANDOMISED TRIAL OF TWO FRACTIONATION SCHEDULES 2ADIOTHER /NCOL +AGEI +
(244) 3UYUKI +
(245) 3HERATO ( 0ROSPECTIVE RANDOMIZED TRIAL OF SINGLE HIGH DOSE VERSUS MULTIPLE FRACTION RADIATION THERAPY FOR THE TREATMENT OF BONE METASTASIS 'AN .O 2INSHO #OLE $* ! RANDOMIZED TRIAL OF A SINGLE TREATMENT VERSUS CONVENTIONAL FRACTIONATION IN THE PALLIATIVE RADIOTHERAPY OF PAINFUL BONE METASTASES #LIN /NCOL 2 #OLL 2ADIOL 0RICE 0
(246) (OSKIN 0*
(247) %ASTON $
(248) !USTIN $
(249) 0ALMER 3'
(250) 9ARNOLD *2 0ROSPECTIVE RANDOMISED TRIAL OF SINGLE AND MULTIFRACTION RADIOTHERAPY SCHEDULES IN THE TREATMENT OF PAINFUL BONY METASTASES 2ADIOTHER /NCOL .IEWALD -
(251) 4KOCZ (*
(252) !BEL 5
(253) 3CHEIB 4
(254) 7ALTER +
(255) .IEDER # ET AL 2APID COURSE RADIATION THERAPY VS MORE STANDARD TREATMENT A RANDOMIZED TRIAL FOR BONE METASTASES )NT * 2ADIAT /NCOL "IOL 0HYS 2ASMUSSON "
(256) 6EJBORG )
(257) *ENSEN !"
(258) !NDERSSON -
(259) "ANNING !-
(260) (OFFMANN 4 ET AL )RRADIATION OF BONE METASTASES IN BREAST CANCER PATIENTS A RANDOMIZED STUDY WITH YEAR FOLLOW UP 2ADIOTHER /NCOL .
(261) (IROKAWA 9
(262) 7ADASAKI +
(263) +ASHIWADO + ! MULTI INSTITUTIONAL PROSPECTIVE RANOMIZED STUDY OF RADIATION THERAPY OF BONE METASTASES *APANESE .IPPON )GAKU (OSHASEN 'AKKAI :ASSHI /KAWA 4
(264) +ITA -
(265) 'OTO -
(266) .ISHIJIMA (
(267) -IYAJI . 2ANDOMIZED PROSPECTIVE CLINICAL STUDY OF SMALL
(268) LARGE AND TWICE A DAY FRACTION RADIOTHERAPY FOR PAINFUL BONE METASTASES 2ADIOTHER /NCOL "LITZER 0( 2EANALYSIS OF THE 24/' STUDY OF THE PALLIATION OF SYMPTOMATIC OSSEOUS METASTASIS #ANCER -ADSEN %, 0AINFUL BONE METASTASIS EFlCACY OF RADIOTHERAPY ASSESSED BY THE PATIENTS A RANDOMIZED TRIAL COMPARING 'Y 8 VERSUS 'Y 8 )NT * 2ADIAT /NCOL "IOL 0HYS 4ONG $
(269) 'ILLICK ,
(270) (ENDRICKSON &2 4HE PALLIATION OF SYMPTOMATIC OSSEOUS METASTASES lNAL RESULTS OF THE 3TUDY BY THE 2ADIATION 4HERAPY /NCOLOGY 'ROUP #ANCER *EREMIC "
(271) 3HIBAMOTO 9
(272) !CIMOVIC ,
(273) -ILICIC "
(274) -ILISAVLJEVIC 3
(275) .IKOLIC . ET AL ! RANDOMIZED TRIAL OF THREE SINGLE DOSE RADIATION THERAPY REGIMENS IN THE TREATMENT OF METASTATIC BONE PAIN )NT * 2ADIAT /NCOL "IOL 0HYS (OSKIN 0*
(276) 0RICE 0
(277) %ASTON $
(278) 2EGAN *
(279) !USTIN $
(280) 0ALMER 3 ET AL ! PROSPECTIVE RANDOMISED TRIAL OF 'Y OR 'Y SINGLE DOSES IN THE TREATMENT OF METASTATIC BONE PAIN 2ADIOTHER /NCOL . 3UMMAR Y 3AMEN VATTING.
(281)
GERELATEERDE DOCUMENTEN
License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden Downloaded from: https://hdl.handle.net/1887/4330.
2ADIOTHERAPY 1SPFGTDISJGU UFSWFSLSJKHJOHWBO EFHSBBEWBO%PDUPSBBOEF6OJWFSTJUFJU-FJEFO PQHF[BHWBOEF3FDUPS.BHOJ¾DVT %S%%#SFJNFS
/UTLINE *OUIJTUIFTJT BWBSJFUZPGUIFRVFTUJPOTUIBUSFNBJOFEVOBOTXFSFEJOUIF
-AHER*"ONEMETASTASISCONSENSUSSTATEMENT NT*2ADIAT/NCOL"IOL0HYS
ETAL RRADIATIONOFBONEMETASTASESINBREASTCANCERPATIENTSARANDOMIZEDSTUDYWITHYEARFOLLOW UP 2ADIOTHER/NCOL
0EREZ#!"ONEMETASTASISREVIEWANDCRITICALANALYSIS OFRANDOMALLOCATIONTRIALSOFLOCALlELDTREATMENT NT*2ADIAT/NCOL"IOL0HYS
'PSUIFTVSWJWBMBOBMZTFT QBUJFOUTXFSFEJWJEFEJOUPQSJNBSZUVNPSHSPVQT CSFBTU QSPTUBUF MVOH BOEPUIFSUZQFTPGDBODFS 0WFSBMM TVSWJWBM 04 XBTTUVEJFEGSPNSBOEPNJ[BUJPO
SURVIVALANDOCCURRENCEOFFRACTURES3&VERSUS-& #FUXFFOUIF4'QBUJFOUTBOE.'QBUJFOUTOPNBKPSEJGGFSFODFTJOBHF TFY QBJOTDPSFBUUJNFPGSBOEPNJ[BUJPO ,BSOPGTLZ1FSGPSNBODF4DBMF
