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Chapter 4: Manuscript B

Chapter 4

Article published in Neuropharmacology, entitled:

“Social isolation rearing in rats alters plasma tryptophan metabolism and is reversed

by sub-chronic clozapine treatment”

Introduction

This chapter presents the full-length manuscript published in Neuropharmacology, published by Elsevier. The manuscript is presented as published by the publisher, and can be viewed or accessed on-line via the journal website:

http://www.sciencedirect.com/science/article/pii/S0028390812000822

Authors’ contributions

• M. Möller designed the study along with BH Harvey, undertook the entire analytical laboratory and statistical analyses as well as the animal study, wrote the first draught of the manuscript, and edited the manuscript after receiving comments from co-authors for publication.

• JL du Preez supervised all aspects of analytical laboratory analysis. • R Emsley advised on the study design and proof read the final manuscript.

• BH Harvey supervised the study design and assisted in the interpretation of the study data, as well as finalized the manuscript for publication.

All co-authors provided permission to use this manuscript as part of M.

Möller’s Ph.D. thesis.

Manuscript B

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Chapter 4: Manuscript B

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Chapter 4: Manuscript B

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Chapter 4: Manuscript B

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Chapter 4: Manuscript B

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Möller designed the study along with JL du Preez, undertook the entire analytical laboratory and statistical analyses as well as the animal study, wrote the first draught of