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Chapter 3: Manuscript A

Chapter 3

Article published in The Journal of Chromatography B, entitled:

“Development and validation of a single analytical method for the determination of

tryptophan, and its kynurenine metabolites in rat plasma”

Introduction

This chapter presents the full-length manuscript published in The Journal of Chromatography B, published by Elsevier. The manuscript is presented as published by the publisher, and can be viewed or accessed on-line via the journal website:

http://www.sciencedirect.com/science/article/pii/S1570023212002553

Authors’ contributions

• M. Möller designed the study along with JL du Preez, undertook the entire analytical laboratory and statistical analyses as well as the animal study, wrote the first draught of the manuscript, and edited the manuscript after receiving comments from co-authors for publication.

• JL du Preez supervised all aspects of the study design and analytical laboratory analysis

• BH Harvey supervised the study design and assisted in the interpretation of the study data, as well as finalized the manuscript for publication.

All co-authors provided permission to use this manuscript as part of M.

Möller’s Ph.D. thesis.

Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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Chapter 3: Manuscript A

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