University of Groningen
Lifestyle, Inflammation, and Vascular Calcification in Kidney Transplant Recipients
Sotomayor, Camilo G.
DOI:
10.33612/diss.135859726
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Publication date: 2020
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Sotomayor, C. G. (2020). Lifestyle, Inflammation, and Vascular Calcification in Kidney Transplant Recipients: Perspectives on Long-Term Outcomes. University of Groningen.
https://doi.org/10.33612/diss.135859726
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Lifestyle, Inflammation
& Vascular Calcification
in Kidney Transplant Recipients:
Perspectives on Long-Term Outcomes
Sotomayor CG
Lifestyle, Infl ammation, and Vascular Calcifi cation in Kidney Transplant Recipients: Perspectives on Long-Term Outcomes.
PhD Dissertation, University of Groningen, Groningen, The Netherlands. This dissertation includes a summary in Dutch and a summary in Spanish.
The doctorate studies presented in this thesis were performed within the framework of Becas de Doctorado en el extranjero, Becas Chile, fi nancially supported by Agencia Nacional de Investigación y Desarrollo (research grant F 72190118). The studies presented in this thesis were based on data of the TransplantLines Insulin Resistance and Infl ammation cohort, which was funded by the Dutch Kidney Foundation (grant C00.1877), and data of the TransplantLines Food and Nutrition Biobank and Cohort Study, which was funded by the Top Institute Food and Nutrition (A-1003).
Financial support for the printing of this thesis from the University of Groningen, University Medical Center Groningen, Dutch Kidney Foundation, and Dutch Heart Foundation is gratefully acknowledged.
Additional fi nancial support for the printing of this thesis was kindly provided by Laboratorio Clínico Tecnoanálisis, Valtek SA, ERBE Nederland BV, Chipsoft BV, Bio-Connect Diagnostics BV, Noord Negentig accountants en belastingadviseurs, and Chiesi Pharmaceuticals, among others, as shown below.
Cover and lay-out: María José Mellado (mlld.mariajose@gmail.com) in Perú. Printing: Michal Slawinsky (thesisprint.eu) in Poland.
ISBN: 978-94-034-2902-1 (printed version) ISBN: 978-94-034-2903-8 (digital version) ©C.G. Sotomayor 2020.
All rights reserved. No part of this publication may be reproduced, copied, modifi ed, stored in a retrieval system, or transmitted without prior written consent of the author. Foundation is gratefully acknowledged.
Lifestyle, Infl ammation, and
Vascular Calcifi cation in
Kidney Transplant Recipients:
Perspectives on Long-Term Outcomes
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnifi cus Prof. C. Wijmenga and in accordance with the decision by the College of Deans. This thesis will be defended in public on Wednesday 28 October 2020 at 11.00 hours
by
Camilo Germán Sotomayor Campos born on 18 January 1993
Supervisors Prof. S.J.L. Bakker Prof. G.J. Navis Prof. R. Rodrigo Assessment Committee Prof. H.G.D. Leuvenink Prof. M.G. Vervloet Prof. C. Ferreccio
Paranymphs Irina Versteeg Yusof Said
TABLE OF CONTENTS
Chapter 1 Introduction and Aims of this Thesis 15 Lifestyle, Inflammation, and Vascular Calcification
in Kidney Transplant Recipients: Perspectives on Long-Term Outcomes
J Clin Med 2020, 9, 1911
Part I Lifestyle; Healthy Diet & Toxic Contaminants 49 Chapter 2 Consumption of Fruits and Vegetables and 51
Cardiovascular Mortality in Renal Transplant Recipients: A Prospective Cohort Study Nephrol Dial Transplant 2020, 35, 357–365
Chapter 3 Fish Intake, Circulating Mercury and Mortality 89 in Renal Transplant Recipients
Nutrients 2018, 10, 1419
Chapter 4 Plasma Cadmium is Associated with Increased 121 Risk of Long-Term Kidney Graft Failure
Kidney Int - Accepted
Part II Inflammation and Oxidative Stress & Vascular 177 Calcification
Chapter 5 Vitamin C Depletion and All-Cause Mortality 179 in Renal Transplant Recipients
Nutrients 2017, 9, 568
Chapter 6 Circulating Advanced Glycation Endproducts and 201 Long-Term Risk of Cardiovascular Mortality in
Kidney Transplant Recipients
Chapter 7 Galectin-3 and Risk of Late Graft Failure in Kidney 235 Transplant Recipients: A 10-years Prospective Cohort
Study
Transplantation - Accepted
Chapter 8 Bone Mineral Density and Aortic Calcification: 265 Evidence for a Bone-Vascular Axis after Kidney
Transplantation
Transplantation - Accepted
Chapter 9 Lifestyle, Inflammation, and Vascular Calcification 289 in Kidney Transplant Recipients: Perspectives on
Long-Term Outcomes
› Summary 291
› Discussion and Future Perspectives 302
Appendix Dutch Summary 325
Spanish Summary 331
Acknowledgements 337
About the Author 345
