University of Groningen
The gut microbiota and inflammatory bowel disease
Collij, Valerie
DOI:
10.33612/diss.150928851
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Publication date: 2021
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Collij, V. (2021). The gut microbiota and inflammatory bowel disease: From exploration to clinical translation. University of Groningen. https://doi.org/10.33612/diss.150928851
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The gut microbiota and
inflammatory bowel disease
From exploration to clinical translation
Printing this thesis was financially supported by the University of Groningen, the Graduate School of Medical Sciences of the University Medical Center Groningen, Norgine, Takeda, Dr. Falk Pharma Benelux B.V. and Tramedico.
Printed by Ipskamp Printing, Enschede, the Netherlands Cover design by Robert Faber
Design and lay-out by Douwe Oppewal, www.oppewal.nl
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author, or when appropriate, of the publishers of the publications included in this thesis.
The gut microbiota and
inflammatory bowel disease
From exploration to clinical translation
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 3 februari 2021 om 14.30 uur
door
Valerie Collij
geboren op 2 april 1993
te Groningen
Promotores Prof. dr. R.K. Weersma Prof. dr. J. Yang-Fu Copromotor Dr. A. Vich Vila Beoordelingscommissie Prof. dr. H.J. Verkade Prof. dr. D. Jonkers Prof. dr. M. Kleerebezem
Paranimfen
Dr. M. Kloosterman Dr. F. Imhann
Table of contents
Chapter 1 Introduction 9
Part I - Exploring the role of the gut microbiota in IBD
Chapter 2 Gut microbiota composition and functional changes in 23 inflammatory bowel disease and irritable bowel syndrome
Science Translational Medicine 2018;10:eaap8914
Chapter 3 Gut microbial co-abundance networks show specificity in 45 inflammatory bowel disease and obesity
Nature Communications 2020;11:4018
Chapter 4 The composition and metabolic potential of the human small 73 intestinal microbiota and its possible implications in IBD
Submitted
Chapter 5 SLC39A8 missense variant is associated with Crohn’s disease 93 but does not have a major impact on gut microbiome composition in healthy subjects
Plos One 2019;14:e0211328
Part II - Clinical translation – Drugs and (meta)genomics
Chapter 6 Drug repositioning in inflammatory bowel disease based 111 on genetic information
Inflammatory bowel disease 2016;22:2562-2570
Chapter 7 Gut microbiome and proteomic changes as biomarker of 129 response to vedolizumab treatment in patients with
inflammatory bowel disease Submitted
Chapter 8 Impact of commonly used drugs on the composition 151 and metabolic function of the gut microbiota
Nature Communications 2020;11:362
Chapter 9 Gut microbiota in inflammatory bowel diseases: 171 Moving from basic science to clinical applications
Human Genetics 2020: doi: 10.1007/s00439-020-02218-3
Chapter 10 Discussion 183
Appendices Nederlandse samenvatting 206
English summary 209
Curriculum vitae 211
List of publications 212
