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University of Groningen On a quest for metabolic fluxes: sampling and inference tools using thermodynamics, metabolome and labelling data Taborda Saldida Alves, Joana

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University of Groningen

On a quest for metabolic fluxes: sampling and inference tools using thermodynamics,

metabolome and labelling data

Taborda Saldida Alves, Joana

DOI:

10.33612/diss.157440136

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2021

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Taborda Saldida Alves, J. (2021). On a quest for metabolic fluxes: sampling and inference tools using thermodynamics, metabolome and labelling data. University of Groningen.

https://doi.org/10.33612/diss.157440136

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Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

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samenvatting

Matthias, thank you for giving me the opportunity of joining your group and for working with me to achieve this goal. I learned immensely during my PhD and I will make good use of it in my future life.

Prof. B. Jayawardhana. Prof. B.M. Bakker, Prof. J. Zanghellini, I greatly appreci-ate that you took the time to read and assess this thesis and that you were part of my PhD committee.

Andreas, you have saved me on endless occasions from wherever I was stuck. Your valuable input and your technical knowledge propelled me to different lands of unknown math. I would have not been able to do this PhD without you, thank you.

Anna, Alfredo and Daniele, thank you for collaborating with me, I learned a lot from you and really enjoyed the process. A special thanks to Anna and Alfredo for welcoming me in Torino. Grazie mille.

To all the members of the MSB group, thank you for making my PhD journey more interesting and pleasant. Álvaro, you were the best house mate someone could hope for, I loved our long dinner talks and sharing my daily life with you for a year. Silke, thanks for being a great office mate and putting up with my occasional (or frequent) emotional explosions. Thank you Serdar and Vakil for spicing up our lunch talks and for putting the ‘philosophical’ into my PhD. Thank you Simeon for helping me with the computational monster of that model. Thank you so much Georg, for setting me up in my journey before you left the group and for teaching me something about experiments. Little Hanna and Yonathan, you were great fun as teaching partners and special thanks to Hanna for helping me translate my summary. Hannah, I loved hanging out with you and Francisca and going out to enjoy what this lovely city has to offer. Francisca, even though your time in the lab was short, you definitely made my PhD life

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284

acknowledgements

better, you gave me good advice and you understood me like no one else could. I am honoured to have been a part of such diverse and interesting group, thank you MSB.

To all the members of the SyMBioSys training network, thank you for being such a fun and inspiring group. I learned a lot in our trainings together and from the discus-sions about our projects. Our trips were not only informative, but also extremely fun and I enjoyed your company immensely.

Team Groningen, you have made my life in Groningen the best I could wish for. Hannah and Landi, I still remember discovering this city with you and having great fun doing it, our trip to South Africa was very special to me. Filippo, you will always be the only soul that I knew when I arrived in this very white landscape, thank you for being so supportive. Tejas, your cool and chilled attitude always made me at ease, thanks for being around during this time. Vincent, don’t lose that party spirit, teasing aside, I really enjoyed it. Steven, you were the friendliest neighbour. Anne-Grete, it was super gezellig to have friends close-by during this last difficult year. Adele, An-nique, Sharon and Alberto, you were a great addition to any party or hang-out, thanks for being always so cheery. Team Groningen, you were all there in endless BBQs, parties, dinners, board games and special moments. I feel very lucky to have made such good friends. Thank you for being a part of my PhD journey.

Casinhas, Inês, Maria e Mariana, um grande obrigado por acreditarem em mim e não me esquecerem durante estes anos em que estive menos presente. Este livro leva um bocadinho de ti Inês, obrigada pela minha capa linda.

Inês, Mafalda e Núria, obrigada por proporcionarem sempre um momento alegre e divertido em cada ida a Lisboa, senti o apoio do Fundo durante estes anos em Groningen.

Catarina, andamos sempre desencontradas por essa Europa fora mas quando fala-mos és a minha velha amiga de sempre, obrigada.

Artur, Renato e Leonor, adorei ter sempre boa companhia nas minhas muitas visitas a Londres e gostei muito das vossas visitas a Groningen. Hugo e Leonor, estiveram lá na última perninha de escrever este livro, obrigada pela paciência e por facilitarem a minha mudança para Londres.

Mário, entendeste-me tão bem desde o início, és um chefe fantástico e deste-me a liberdade que eu precisava para acabar este livro, obrigada.

Jhonatan and Simone, I loved the moments and laughs we shared. Thank you for being there for me during this long journey.

My dear paranymphs, Désirée and Niek, you definitely know how important and difficult this process was for me, and having you by my side throughout this journey

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acknowledgements

made it more fun and less painful. Thank you for all the support, all the love (that I really, really needed) and for being next to me on my defense. You are amazing friends!

Paolo, I wish there was another, stronger, word for thank you. You carried me over all my many difficult moments and celebrated with me the happy ones. You were absolutely essential during all the stages of this PhD journey and my best adviser on everything. Ti sarò per sempre grata.

Família pipoca, mãe, pai e João, foram uns anos atribulados cheios de saudades, bons momentos e frustração. Tudo o que eu fiz até agora foi sempre um fruto do que vocês me deram ao longo da vida. Sem o vosso apoio e amor, eu não tinha chegado longe. Obrigada por me aturarem sempre, por se preocuparem comigo e por serem a

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