University of Groningen
Positron emission tomography in infections associated with immune dysfunction
Ankrah, Alfred
DOI:
10.33612/diss.144628960
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Ankrah, A. (2020). Positron emission tomography in infections associated with immune dysfunction. University of Groningen. https://doi.org/10.33612/diss.144628960
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Propositions
1. Positron emission tomography (PET) integrated with computed tomography (CT) or magnetic resonance (MRI) can provide a pre-therapeutic metabolic map of invasive fungal infections (IFIs) and tuberculosis (This thesis, chapters 6 and 10).
2. F18-fluorodeoxyglucose PET (FDG PET) can be used to identify patients with subclinical tuberculosis (TB) (This thesis, chapter 10).
3. FDG PET/CT can predict patients with latent tuberculosis infection who are likely to progress to overt disease (This thesis, chapter 10).
4. Gallium citrate PET has a clearer definition and detection of intracerebral lesions and may be indicated for evaluation of intracerebral granulomatous lesions (This thesis, chapter 14).
5. Gallium (68) citrate is less likely to accumulate in post-infective inflammation and may be useful in the evaluation of residual disease on completion of treatment (This thesis, chapter 14).
6. The use of Gallium (68) citrate is an attractive alternative for a PET tracer in developing countries with the greatest burden of infection associated with immune dysfunction (This thesis, chapter 15).
7. Global total lesion glycolysis and global metabolic volume are better metabolic indices for measuring infections associated with immune dysfunction compared to standardized uptake value (This thesis, chapter 9).
8. PET/CT is a useful imaging biomarker in infections that must be used together with other biomarkers (This thesis, chapter 13).
9. Early metabolic changes from PET in infections support clinical decision making in infections associated with immune dysfunction (This thesis, chapter 15).
10. The metabolic uptake in reactive lymphadenopathy due to Human immunodeficiency virus is proportional to the CD 4 count and inversely proportional to the viral load. These parameters must be carefully considered in the interpretation of a scan with a suspected infection associated with immune dysfunction (This thesis, chapter 4).
11. The imaging of hypoxia in latent tuberculosis infection may help stratify patient who need preventive TB therapy (This thesis, chapter 12).
12. If I have seen ‘anything’ it is because I stood on the shoulders of giants (adapted, Sir Isaac Newton). 13. In the evaluation of patients with TB-HIV coinfection with PET/CT, expect the unexpected and remember
patients do not read text books!
