• No results found

University of Groningen The right ventricle in heart failure with preserved ejection fraction Gorter, Thomas Michiel

N/A
N/A
Protected

Academic year: 2021

Share "University of Groningen The right ventricle in heart failure with preserved ejection fraction Gorter, Thomas Michiel"

Copied!
10
0
0

Bezig met laden.... (Bekijk nu de volledige tekst)

Hele tekst

(1)

University of Groningen

The right ventricle in heart failure with preserved ejection fraction

Gorter, Thomas Michiel

IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.

Document Version

Publisher's PDF, also known as Version of record

Publication date: 2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Gorter, T. M. (2018). The right ventricle in heart failure with preserved ejection fraction. Rijksuniversiteit Groningen.

Copyright

Other than for strictly personal use, it is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), unless the work is under an open content license (like Creative Commons).

Take-down policy

If you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim.

Downloaded from the University of Groningen/UMCG research database (Pure): http://www.rug.nl/research/portal. For technical reasons the number of authors shown on this cover page is limited to 10 maximum.

(2)
(3)

Financial support by Abbott Medical Nederland BV, Actelion Pharmaceuticals Nederland BV, Bayer BV, Bracco Imaging Europe BV, GUIDE, Medis Medical Imaging Systems BV, Novartis Pharma BV and Rijksuniversiteit Groningen for the publication of this thesis, is gratefully acknowledged.

Copyright 2018 Thomas Michiel Gorter

All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without permission of the authors and, when appropriate, the publisher holding the copyrights of the published articles.

ISBN 978-94-6233-971-2

Cover design and layout by: Claudia Gonzalez Arevalo argo1983@gmail.com

https://clavitos.wixsite.com/graphicportfolio Printed by: Gildeprint

(4)

The Right Ventricle

In Heart Failure with Preserved Ejection Fraction

(5)
(6)

The right ventricle in heart failure with

preserved ejection fraction

Proefschrift

ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen

op gezag van de

rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.

De openbare verdediging zal plaatsvinden op woensdag 6 juni 2018 om 14.30 uur

door

Thomas Michiel Gorter

geboren op 25 juli 1988 te Enschede

(7)

Promotor

Prof. dr. D.J. van Veldhuisen

Copromotores Dr. J.P. van Melle Dr. M. Rienstra Dr. T.P. Willems Beoordelingscommissie Prof. dr. J.J. Bax

Prof. dr. M.P. van den Berg Prof. dr. R.A.J.O. Dierckx

(8)

Paranimfen

Sander Gorter

(9)

Chapter 1 Introduction and aims

10

Chapter 2 Right ventricular dysfunction in heart failure with

preserved ejection fraction: a systematic review and meta-analysis

19

Eur J Heart Fail 2016

Chapter 3 Right ventricular-vascular coupling in heart failure

with preserved ejection fraction and pre- versus post-capillary pulmonary hypertension

58

Eur Heart J Cardiovasc Imaging 2018

Chapter 4 Exercise unmasks distinct pathophysiologic

features in heart failure with preserved ejection fraction and pulmonary vascular disease

77

Submitted

Chapter 5 Right heart dysfunction in heart failure with

preserved ejection fraction: The impact of atrial fibrillation

97

J Card Fail 2018

Table of

Contents

(10)

Chapter 6 Diabetes mellitus and right ventricular dysfunction

in heart failure with preserved ejection fraction

113

Am J Cardiol 2018

Chapter 7 Right heart dysfunction and failure in heart failure

with preserved ejection fraction: mechanisms and management

127

Eur J Heart Fail 2018

Chapter 8 Measuring pulmonary artery pressures in heart

failure: A new useful diagnostic tool?

171

Circulation 2017

Chapter 9 General discussion and future perspectives

177

Appendices Dutch Summary

193

About the author

199

Acknowledgments

200

Referenties

GERELATEERDE DOCUMENTEN

previously demonstrated the reduced RV systolic function coupled with higher pulmonary pressures was associated with poor prognosis in patients with left-sided heart failure

The HFpEF criteria used for study selection were any (sub)group of patients with signs and/or symptoms of heart failure (HF) or HF hospitalization <12 months; in combination

COPD chronic obstructive pulmonary disease; FAC fractional area change; FWLS free wall longitudinal strain; HF heart failure; LAVi left atrial volume

BP, blood pressure; Ea, effective arterial elastance; LVTMP, left ventricular transmural pressure; PA, pulmonary artery; PAC pulmonary arterial compliance; PCWP, pulmonary

RA reservoir strain could be measured in 70 (76.9%) patients, RA volume and emptying fraction in 72 (80.0%) and RA compliance in 56 (61.5%) of the patients.. AF atrial fibrillation;

Diabetes mellitus is a common comorbidity in patients with heart failure with preserved ejection fraction (HFpEF), 1,2 and is independently associated with increased morbidity..

ACEi angiotensin-converting enzyme inhibitor; ARB angiotensin receptor blocker; ARNI angiotensin receptor- neprilysin inhibitor; CCB calcium channel blocker; cGMP cyclic

In this study, and I believe it is for proper future research as well, I have firstly demonstrated that studying social dynamics of leadership with a fine lens should take