University of Groningen
Diminished ovarian reserve and adverse reproductive outcomes
de Carvalho Honorato, Talita
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Publication date: 2017
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de Carvalho Honorato, T. (2017). Diminished ovarian reserve and adverse reproductive outcomes: Epidemiologic studies on their association. University of Groningen.
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Diminished ovarian reserve and
adverse reproductive outcomes
Epidemiologic studies on their association
Talita de Carvalho Honorato
The research presented in this thesis was financially supported by the Abel Tasman talented Program, University of Groningen and by the Department of Obstetrics and Gynaecology of the University Medical Centre Groningen.
The printing of this thesis was financially supported by the University of Groningen, the University Medical Centre Groningen and the SHARE research institute of the Graduate School of Medical Sciences.
ISBN
978-94-034-0126-3 (hardcopy) 978-94-034-0125-6 (digital) Copyright © 2017 TC Honorato
All rights reserved. No part of this publication may be reproduced or transmitted in any form or by any means without written permission of the author and the publisher holding respective copyrights of the published articles, if applicable.
Cover design: Talita de Carvalho Honorato
Diminished ovarian reserve and
adverse reproductive outcomes
Epidemiologic studies on their association
PhD thesis
to obtain the degree of PhD at the
University of Groningen
on the authority of the
Rector Magnificus Prof. E. Sterken
and in accordance with
the decision by the College of Deans.
This thesis will be defended in public on
Monday October 9 2017 at 12.45 hours
by
Talita de Carvalho Honorato
born on 17 April 1984
in Araraquara-SP, Brazil
Supervisors
Prof. A. Hoek
Prof. H.M. Boezen
Co-supervisors
Dr. H. Groen
Dr. M.L. Haadsma
Assessment committee
Prof. C.M.A. van Ravenswaaij-Arts
Prof. J.J.H.M Erwich
Paranymphs
Violeta Stojanoviska
Marcin Rzeszewicz
Table of contents
Chapter 1
Introduction, hypothesis and aim of this thesis 9
Chapter 2 Follicle pool, ovarian surgery and the risk for a subsequent trisomic pregnancy 29
Human Reproduction (2015) 30 (3): 717-722 Chapter 3 Low oocyte yield during IVF treatment and the risk of a trisomic pregnancy 43
Accepted Reproductive BioMedicine Online Chapter 4 Miscarriage risk in women with repeated poor ovarian response during IVF treatment 59
Submitted Chapter 5 Miscarriage risk for women exposed to cigarette smoke in-utero 75
Accepted Menopause Chapter 6 In-utero cigarette smoke exposure and the risk of earlier menopause 95
Submitted Chapter 7 Summary, general discussion and future perspectives 115
References 129
Summary English 149
Summary Dutch 152
Acknowledgments 155
Research Institute SHARE 160
