The handle http://hdl.handle.net/1887/33206 holds various files of this Leiden University dissertation.
Author: Verbeek, Floris Paul Reinier
Title: Image-guided cancer surgery : the value of near-infrared fluorescence imaging during oncologic and gastrointestinal procedures
Issue Date: 2015-06-03
Image-Guided Cancer Surgery
Th e value of near-infrared fl uorescence imaging during oncologic and gastrointestinal procedures
Floris P.R. Verbeek
in any form or by any means, without permission of the author.
ISBN: 978-94-6169-655-7
Layout and printing: Optima Grafi sche Communicatie, Rotterdam, Th e Netherlands Th is thesis is also available as an e-pub. www.e-pubs.nl?epub=f.verbeek
Th e research described in this thesis was fi nancially supported by the Dutch Cancer Society (UL 2010-4732), the Center for Translational Molecular Medicine (CTMM, DeCoDe and MUSIS projects) and the Leiden University Fund/Piso Kuperus.
Financial support by the Dutch Cancer Society, On Target Laboratories, AbbVie, Applied Medical, ChipSoft , ERBE, Fluoptics, Karl Storz, Pfi zer, Roche Nederland and de Nederlandse Vereniging voor Gastroenterologie for the printing of this thesis is gratefully acknowledged.
Image-Guided Cancer Surgery
Th e value of near-infrared fl uorescence imaging during oncologic and gastrointestinal procedures
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van Rector Magnifi cus prof.mr. C.J.J.M. Stolker,
volgens besluit van het College voor Promoties te verdedigen op woensdag 3 juni 2015
klokke 16.15 uur
door
Floris Paul Reinier Verbeek geboren te Naarden
in 1988
Prof. dr. V.T.H.B.M. Smit
Prof. dr. T.M. van Gulik (Universiteit van Amsterdam)
Voor Laura Aan mijn ouders
Contents
Chapter 1 General introduction and outline of the thesis 9 Part I Intraoperative evaluation of surgical margins 19 Chapter 2 Near-infrared fl uorescence imaging of both colorectal cancer
and ureters using a low-dose integrin targeted probe 21 Chapter 3 Real-time intraoperative detection of breast cancer using near-
infrared fl uorescence imaging and methylene blue 37 Chapter 4 Image-guided hepatopancreatobiliary surgery using near-
infrared fl uorescent light 53
Part II Sentinel lymph node imaging 75
Chapter 5 Near-infrared fl uorescence sentinel lymph node mapping in
breast cancer: a multicenter experience 77
Chapter 6 Clinical trial of combined radio- and fl uorescence-guided senti-
nel lymph node biopsy in breast cancer 95
Chapter 7 Improved sentinel lymph node biopsy in melanoma patients by combining radioactive and fl uorescence guidance 111 Chapter 8 Optimization of sentinel lymph node mapping in bladder cancer
using near-infrared fl uorescence 121
Chapter 9 Comparison of lymphatic tracers for near-infrared fl uorescence sentinel lymph node biopsy in vulvar cancer 135
Part III Vital structure imaging 151
Chapter 10 Intraoperative near infrared fl uorescence guided identifi cation of the ureters using low dose methylene blue: a fi rst in human experience
153
Chapter 11 Optimization of near-infrared fl uorescence cholangiography for
open and laparoscopic surgery 165
Part IV 179
Chapter 12 Summary and Future perspectives 181
Nederlandse samenvatting 191
List of Publications 199
Curriculum Vitae 203
Dankwoord 205
