University of Groningen
Hemostatic system activation and reperfusion injury in liver machine preservation and
transplantation of extended criteria donor livers
Karangwa, Shanice
DOI:
10.33612/diss.161905515
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Publication date:
2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Karangwa, S. (2021). Hemostatic system activation and reperfusion injury in liver machine preservation and
transplantation of extended criteria donor livers. University of Groningen.
https://doi.org/10.33612/diss.161905515
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Hemostatic system activation and reperfusion injury
in liver machine preservation and transplantation of
extended criteria donor livers
COLOFON
Hemostatic system activation and reperfusion injury in liver machine preservation and transplantation of extended criteria donor livers
Shanice A Karangwa
© Copyright S. A. Karangwa 2021, Amsterdam, the Netherlands
All rights reserved. No parts of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means without written permission of the author or the publisher holding the copyright of the published articles.
Cover: Kenneth Mugisha
Printing: Ridderprint ǀ www.ridderprint.nl
Financial support for printing of this thesis was obtained by generous contributions from the University of Groningen, University Medical Center Groningen, Graduate School of Medical Sciences (Research insitutue GUIDE) and the Nederlandse Transplantatie Vereniging
Hemostatic system activation and reperfusion
injury in liver machine preservation and
transplantation of extended criteria donor livers
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the Rector Magnificus Prof. C. Wijmenga
and in accordance with the decision by the College of Deans. This thesis will be defended in public on
Wednesday 7 April 2021 at 16:15 hours by
Shanice Amy Karangwa
born on 16 June 1993 in Nairobi, Kenya
Promotores
Prof. dr. R.J. Porte Prof. dr. J.A. Lisman
Assessment committee
Prof. dr. I.P.J. Alwayn Prof. dr. K.N. Faber Prof. dr. K. Meijer
Paranymphs:
Drs. S. L. Meyer
Table of contents
Chapter 1 General introduction and outline of this thesis
Part I. Activation of the hemostatic system
Chapter 2 DCD liver transplantation is not associated with hyper-fibrinolysis and increased blood loss after graft reperfusion
Transplantation 2021 (accepted)
Chapter 3 Activation of fibrinolysis, but not coagulation, during end-ischemic ex-situ normothermic machine perfusion of human donor livers
Transplantation. 2017; 101: e42-e48
Chapter 4 Production of physiologically relevant quantities of hemostatic proteins during normothermic machine perfusion of human livers
Liver Transpl 2018; 24: 1298-1302.
Chapter 5 Anti-coagulant management and synthesis of hemostatic proteins during machine preservation of livers for transplantation
Semin Thromb Hemost 2020 Sep;46(6):743-750
Part II. Reperfusion Injury
Chapter 6 The effect of arterialization time on outcomes in DCD liver transplantation
Manuscript in preparation
Chapter 7 Machine perfusion of donor livers for transplantation: A proposal for standardized nomenclature and reporting Guidelines.
Am J Transplant. 2016; 16: 2932-2942.
Chapter 8 Hypothermic machine perfusion in liver transplantation
Int.J.Surg 2020; S1743-9191(20)30356-3
Chapter 9 Cytokine adsorption to mitigate ischemia-reperfusion injury during ex-situ normothermic machine perfusion of porcine livers: A pilot study
Manuscript in preparation
Chapter 10 Summary, Discussion, and Future perspectives Chapter 11 Summary in Dutch │Nederlandse samenvatting
List of publications Acknowledgements Biography
