University of Groningen
From the wound to the bench
García Pérez, Andrea
DOI:
10.33612/diss.128078435
IMPORTANT NOTE: You are advised to consult the publisher's version (publisher's PDF) if you wish to cite from it. Please check the document version below.
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
García Pérez, A. (2020). From the wound to the bench: A study of wound-colonising bacteria and their interactions. University of Groningen. https://doi.org/10.33612/diss.128078435
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STELLINGEN
behorende bij het proefschrift: From the wound to the bench:
A study of wound-colonising bacteria and their interactions
1. “Though human ingenuity may make various inventions which, by the help of various machines answering the same end, it will never devise any inventions more beautiful, nor simpler, nor more to the purpose than nature does; because in her inventions nothing is wanting, and nothing is superfluous.” Da Vinci
2. Just as nothing in nature is redundant, bacteria display a supply of ‘moonlighting’ proteins with multiple functions, which are relevant for the organism’s fitness and, in the case of a pathogen, its virulence hallmark (Chapter 3).
3. In the context of long-term bacterial colonisation of a chronic wound, the influence of intra-species heterogeneity by cause of hypermutable strains plays a role in the intra-species’
persistence, chronic infection, and the development of antibiotic resistance (Chapter 3). 4. Co-colonising bacteria from chronic wounds can pacify Staphylococcus aureus (Chapters 3
and 4).
5. Klebsiella oxytoca and Bacillus thuringiensis trigger massive rearrangements in S. aureus physiology (Chapter 4).
6. The study of bacteria in a broader biological context, such as a chronic wound environment, allows the discovery of new bacterial proteins that could represent an important foundation for microbiome cross-talk and bacterial homeostasis (Chapters 4 and 5).
7. Future anti-S. aureus therapy should consider targets highly expressed in polymicrobial settings (Chapters 4 and 5).
8. A larger thesis cannot compensate for the lack of something.
9. “Perhaps everything terrible is, in its deepest being, something that needs our love” R.M. Rilke
