University of Groningen
Enhancing the antimicrobial potential of lanthipeptides by employing different engineering
strategies
Zhao, Xinghong
DOI:
10.33612/diss.127409437
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Publication date: 2020
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Zhao, X. (2020). Enhancing the antimicrobial potential of lanthipeptides by employing different engineering strategies. University of Groningen. https://doi.org/10.33612/diss.127409437
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Stellingen behorende bij het proefschrift
Enhancing the antimicrobial potential of lanthipeptides by
employing different engineering strategies
Xinghong Zhao
1. Engineering of lanthipeptides with different antimicrobial motifs provides an alternative approach for discovering antimicrobials. 2. The discovery of antimicrobial peptides can be achieved by using
non-ribosomally produced antimicrobial peptides as design-scaffolds for subsequent production of ribosomally synthesized and posttranslationally modified mimics.
3. The most important requirements for druggability of new antimicrobial compounds are safety, suitable pharmacokinetics and pharmacodynamics.
4. The recent coronavirus outbreak and the increasing number of antimicrobial-resistant pathogens call for both increased efforts in the fundamental understanding of proliferation and transmission of viruses and microbes, as well as for enhanced drug development programs.
5. Many RiPPs are excellent antimicrobials in their natural environment, but it remains to be seen whether they can be used as antibiotics in man.
6. Pharmaceutical engineering plays a vital role in broadening the application of drugs. (Chapter 5)
7. The proposition, “The proposition No. 7 of Xinghong Zhao is incorrect”, is correct.
