University of Groningen
Exploring the regeneration potential of salivary glands using organoids as a model Rocchi, Cecilia
DOI:
10.33612/diss.168896082
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Publication date: 2021
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Rocchi, C. (2021). Exploring the regeneration potential of salivary glands using organoids as a model. University of Groningen. https://doi.org/10.33612/diss.168896082
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Exploring the Regeneration
Potential of Salivary Glands using
Organoids as a Model
Rocchi, C.
Exploring the Regeneration Potential of Salivary Glands using Organoids as a Model PhD dissertation, University of Groningen, The Netherlands
© Copyright 2021, Cecilia Rocchi. All rights reserved. No parts of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means without prior permission of the author, or when appropriate, of the publisher of the published articles.
Cover Design: Emily Fong.
www.emilyfongstudio.com
© Copyright & copy;2021 Emily Fong. All rights reserved.
Exploring the regeneration
potential of salivary glands using
organoids as a model
PhD thesis
to obtain the degree of PhD at the University of Groningen
on the authority of the
Rector Magnificus Prof. C. Wijmenga and in accordance with
the decision by the College of Deans. This thesis will be defended in public on Wednesday 26 May 2021 at 14.30 hours
by
Cecilia Rocchi
born on 29 July 1985 in Reggio Emilia, Italy
Supervisor
Prof. R.P. CoppesCo-supervisors
Dr. R.P. van Os Dr. L. BarazzuolAssessment Committee
Prof. G. de Haan Prof. C. Ovitt Prof. M. VerheijParanymphs
Peter Nagle
TABLE OF CONTENTS
CHAPTER 1
GENERAL INTRODUCTION & OUTLINE OF THE THESIS... 1
CHAPTER 2
THE EVOLVING DEFINITION OF SALIVARY GLAND STEM CELLS ... 7
Npj Nature Regenerative Medicine 2021;6(4) CHAPTER 3
LONG-TERM IN VITRO EXPANSION OF SALIVARY GLAND STEM CELLS
DRIVEN BY WNT SIGNALS ... 28
Stem Cell Reports. 2016 Jan 12;6(1):150-62. CHAPTER 4
THE HIPPO SIGNALING PATHWAY EFFECTOR YAP REGULATES SALIVARY GLAND REGENERATION AFTER INJURY ... 57
Under revision in Science Signalling CHAPTER 5
AUTOPHAGY INDUCTION DURING STEM CELL ACTIVATION PLAYS A KEY ROLE IN SALIVARY GLAND SELF-RENEWAL ... 90
Accepted in Autophagy CHAPTER 6
A MOLECULAR NETWORK-BASED APPROACH REVEALS HUMAN SALIVARY GLAND STEM CELL FEATURES ... 134
In preparation CHAPTER 7
GMP COMPLIANT ISOLATION AND EXPANSION OF PRIMARY HUMAN-DERIVED SALIVARY GLAND ORGANOIDS FOR AUTOLOGOUS CELL-BASED THERAPY FOR XEROSTOMIA ... 165
In preparation CHAPTER 8
SUMMARY & DISCUSSION ... 196
CHAPTER 9 APPENDICES ... 214 Nederlandse Samenvatting Acknowledgements Curriculum vitae List of Publications
