University of Groningen
DAMPs, endogenous danger signals fueling airway inflammation in COPD
Pouwels, Simon
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2017
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Pouwels, S. (2017). DAMPs, endogenous danger signals fueling airway inflammation in COPD.
Rijksuniversiteit Groningen.
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DAMPs, endogenous danger signals fueling
airway inflammation in COPD
ISBN: 978-90-367-9766-5 (book) ISBN: 978-90-367-9765-8 (e-pub) Cover: Luciana Nedelea
Lay-out: Proefschrift Groningen, Peter van der Sijde Printing: Zalsman, Groningen
© 2017, Simon D. Pouwels, The Netherlands
All rights reserved. No parts of this thesis may be reproduced or transmitted in any form, by any means, without prior written permission from the author.
Printing of this thesis was financially supported by: University of Groningen (RUG), the graduate school of Medical Sciences Groningen (GUIDE), het Longfonds and Stichting Astma Bestrijding (SAB).
The research presented in this thesis was financially supported by: Het Longfonds (Netherlands Lung Foundation), Stichting Asthma Bestrijding (SAB), Jan Kornelis de Cock Stichting, Noordelijke CARA Stichting (NCS), Netherlands Respiratory Society (NRS).
DAMPs, endogenous danger signals
fueling airway inflammation in COPD
Proefschrift
ter verkrijging van de graad van doctor aan de
Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken
en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op
woensdag 10 mei 2017 om 16.00 uur
door
Simon Daniël Pouwels
geboren op 28 oktober 1987
Promotores
Prof. dr. I.H. Heijink
Prof. dr. A.J.M. van Oosterhout
Copromotor
Dr. ir. M.C. Nawijn
Beoordelingscommissie
Prof. dr. G. Brusselle
Prof. dr. D.V. Krysko
Prof. dr. P. Heeringa
Paranimfen
Valerie R. Wiersma-Pouwels
Laura Hesse
TABLE OF CONTENTS
Chapter I General introduction, background & scope of this thesis 9
Chapter II DAMPs activating innate and adaptive immune responses in COPD 19
Mucosal Immunol. 2014;7: 215-26
Chapter III Cigarette smoke-induced necroptosis and DAMP release trigger neutrophilic 37 airway inflammation in mice
Am J Physiol Lung Cell Mol Physiol. 2016;310: L377-86
Chapter IV Susceptibility for cigarette smoke-induced DAMP release and DAMP-induced 51 inflammation in COPD
Am J Physiol Lung Cell Mol Physiol. 2016;311: L881-L892
Chapter V Genetic variation associates with susceptibility for cigarette smoke-induced 69 neutrophilia in mice
Am J Physiol Lung Cell Mol Physiol. 2015;308: L693-709
Chapter VI A specific DAMP profile identifies susceptibility to smoke-induced airway 91 inflammation
Eur Respir J. 2014;43: 1183-6
Chapter VII Genetic variance is associated with susceptibility for cigarette smoke-induced 95
DAMP release in mice
Am J Physiol Lung Cell Mol Physiol. In revision
Chapter VIII Increased serum levels of LL37, HMGB1 and S100A9 during 121 exacerbation in COPDpatients
Eur Respir J. 2015;45: 1482-5
Chapter IX Increased neutrophil expression of pattern recognition receptors during 127
COPD exacerbations
Respirology. 2017;22: 401-404
Chapter X Cigarette smoke-induced damage-associated molecular pattern release 133 from necrotic neutrophils triggers proinflammatory mediator release
Am J Respir Cell Mol Biol. 2015;52: 554-62
Chapter XI Advanced glycation endproducts and their receptor in different body 147 compartments in COPD
Chapter XII Summary, general discussion & future perspectives 169
Chapter XIII Nederlandse samenvatting / Dutch summary 189
Chapter XIV Dankwoord / Acknowledgements 199
Appendix I List of publications 205
