therapy
Willems, H.P.J.
Citation
Willems, H. P. J. (2006, November 29). Hyperhomocysteinemia and venous thrombosis :
studies into risk and therapy. Retrieved from https://hdl.handle.net/1887/5417
Version:
Corrected Publisher’s Version
License:
Licence agreement concerning inclusion of doctoral thesis in the
Institutional Repository of the University of Leiden
Downloaded from:
https://hdl.handle.net/1887/5417
Hyperhomocysteinemia and venous thrombosis
Studies into risk and therapy
Hyperhomocysteinemia and venous thrombosis
Studies into risk and therapy
PROEFSCHRIFT
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden, op gezag van de rector Magnificus Dr. D.D. Breimer,
hoogleraar in de faculteit der Wiskunde en Natuurwetenschappen en die der Geneeskunde,
volgens besluit van het College voor Promoties te verdedigen op
woensdag 29 november 2006 klokke 16.15 uur
door
Promotor Prof. dr. F.R. Rosendaal Co-promotores Dr. G.M.J. Bos Dr. M. den Heijer Referent Prof. dr. H.R. Büller Overige leden Prof. dr. A. Algra Dr. H. Blom
Prof. dr. A.J. Rabelink
Contents
Chapter 1 General introduction 7 Chapter 2 Homocysteine and venous thrombosis: outline of a vitamin 15 intervention trial
Chapter 3 Acidic citrate stabilizes blood samples for assay of 31 total homocysteine.
Chapter 4 Comparison between acidic citrate and EDTA as anticoagulant 39 for measurement of homocysteine concentration
Chapter 5 Influence of coumarins on homocysteine concentration. 51 Chapter 6 The elevated risk for venous thrombosis in persons 63
with hyperhomocysteinemia is not reflected by the endogenous thrombin potential
Chapter 7 Homocysteine as risk factor for venous thrombosis in the 69 elderly
Chapter 8 Homocysteine lowering by B vitamins and the prevention 77 of deep-vein thrombosis and pulmonary embolism.
A randomized, placebo-controlled, double-blind, secondary prevention intervention trial.
Chapter 9 General discussion 91
Samenvatting 99
Dankwoord 103
