University of Groningen Inflammatory Bowel Disease Visschedijk, Marijn

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University of Groningen

Inflammatory Bowel Disease

Visschedijk, Marijn

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Publication date:

2018

Link to publication in University of Groningen/UMCG research database

Citation for published version (APA):

Visschedijk, M. (2018). Inflammatory Bowel Disease: 'New genes, rare variants & moving towards clinical

practice'. Rijksuniversiteit Groningen.

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521405-L-sub02-st-Visschedijk

Processed on: 23-7-2018 Processed on: 23-7-2018 Processed on: 23-7-2018 Processed on: 23-7-2018

STELLINGEN/ PROPOSITIONS

1. In genetic association studies, replication in independent cohorts is necessary to reduce false positive results, specifically in the context of rare variants (this thesis) 2. Rare variants, associated with complex disease, can be population-specific (this

thesis)

3. Pooling of DNA in next generation sequencing studies for screening for rare variants is a safe option. (this thesis)

4. IBD nurses are excellent in scoring the disease behaviour and disease location according to the Montreal Classification (this thesis)

5. A genetic variant in WWOX and in lncRNA RP11-679B19.1 is associated, as a disease-modifying variant, with recurrent fibrostenotic CD (this thesis)

6. Genetic variants associated with disease onset are different from those associated with disease behaviour, which suggests that the biological pathways that underlie disease behaviour can be distinct from those that underlie disease onset (this thesis)

7. Although precision medicine is not yet feasible, the developments in the genetics of IBD are coming closer to directly improving patient care (this thesis)

8. Als je ergens expert in wordt tijdens het doen van promotieonderzoek dan is het zoeken met Google

9. Geluk zit in een klein hoekje (Neil Pasricha) 10. Schaakstelling: mat in 2, wit aan zet