University of Groningen
Mechanistic and translational studies to improve cisplatin sensitivity of testicular cancer
de Vries, Gerda
DOI:
10.33612/diss.135496604
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Publication date: 2020
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de Vries, G. (2020). Mechanistic and translational studies to improve cisplatin sensitivity of testicular cancer. https://doi.org/10.33612/diss.135496604
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Mechanistic and translational
studies to improve cisplatin
sensitivity of testicular cancer
Printing of this thesis was financially supported by UMCG Graduate School of Medical Sciences, Stichting Werkgroep Interne Oncologie and the University of Groningen.
Printed by Ipskamp Printing
Enschede, the Netherlands Design & layout Bianca Pijl, www.pijlldesign.nl Groningen, the Netherlands
© Copyright: 2020 G. de Vries, Groningen, the Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, without prior written permission of the author, or when appropriate, of the publishers of the publications included in this thesis.
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties
De openbare verdediging zal plaatsvinden op woensdag 21 oktober 2020 om 12.45 uur
door
Gerda de Vries
geboren op 13 augustus 1989 te Leeuwarden
Mechanistic and translational
studies to improve cisplatin
sensitivity of testicular cancer
Promotores Prof. dr. S. de Jong Prof. dr. J.A. Gietema Prof. dr. M.A.T.M. van Vugt Beoordelingscommissie Prof. dr. A. Samali
Prof. dr. J.J. Schuringa Prof. dr. W. Helfrich
Paranimfen
Jolanda A.L. Liefers-Visser Margot de Looff
Chapter 1 Chapter 2 Chapter 3 Chapter 4 Chapter 5 Chapter 6 Chapter 7 Chapter 8 Appendices Table of contents General Introduction
Testicular cancer: determinants of cisplatin sensitivity and novel therapeutic opportunities
Cancer Treat. Rev. 2020;88:102054.
Dual mTORC1/2 inhibition sensitizes testicular cancer models to cisplatin treatment
Mol. Cancer Ther. 2020;9:590–601.
MDM2 inhibitors sensitize testicular cancer models to mTORC1/2 inhibitors and cisplatin
Manuscript in preparation
Establishment and characterization of testicular cancer patient-derived xenograft models for preclinical evaluation of novel therapeutic strategies
Manuscript accepted; Sci. Rep.
Modulation of p21 expression does not affect cisplatin sensitivity of testicular cancer cells
Summary
Discussion an Future perspectives
Nederlandse samenvatting (Summary in Dutch)
About the author List of publications Dankwoord (Acknowledgements) 9 11 49 79 113 151 173 175 179 191 193 199 201 203 205
