University of Groningen
Molecular imaging of immunotherapy biodistribution and the tumor immune environment
Suurs, Frans
DOI:
10.33612/diss.149059939
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Publication date: 2021
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
Suurs, F. (2021). Molecular imaging of immunotherapy biodistribution and the tumor immune environment. University of Groningen. https://doi.org/10.33612/diss.149059939
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Frans Valentijn Suurs
Molecular imaging of
immunotherapy biodistribution
and the tumor immune
environment
Suurs, F.V.
Molecular imaging of immunotherapy biodistribution and the tumor immune environment Thesis, University of Groningen, Groningen, The Netherlands
ISBN:
ISBN (electronic version): © F.V. Suurs, 2020
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, mechanically, by photocopying, recording, or otherwise, without prior permission of the author.
Cover: Gildeprint and Frans Suurs Layout: Frans Suurs
Printing by: Gildeprint
Printing of this thesis was supported by:
Stichting Werkgroep Interne Oncologie Graduate School of
Molecular imaging of
immunotherapy biodistribution
and the tumor immune
environment
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op maandag 4 januari 2021 om 16.15 uur
door
Frans Valentijn Suurs
geboren op 4 september 1989 te Amsterdam
Promotores
Prof. dr. E.G.E. de Vries Prof. dr. M.N. Lub - de Hooge Copromotores
Dr. D.J.A. de Groot Beoordelingscommissie Prof. dr. A.W.J.M. Glaudemans Prof. dr. J.G.W. Kosterink Prof. dr. A.D.R. Huitema
Paranimfen
Arkajyoti Bhattacharya Thomas V. Wagner Linda N. Broer
CONTENTS
Chapter 1 General introduction 9
Chapter 2 A review of bispecific antibodies and antibody constructs in
oncology and clinical challenges
Pharmacol Ther. 2019;201:103-19
15
Chapter 3 Biodistribution of a CD3/EpCAM bispecific T-cell engager is
driven by the CD3 arm
J Nucl Med. 2020;61:1594-601
61
Chapter 4 Mesothelin/CD3 half-life extended bispecific T-cell engager
molecule shows specific tumor uptake and distributes to mesothelin and CD3 expressing tissues
Submitted
87
Chapter 5 89Zr-labeled Bispecific T-cell Engager AMG 211 PET shows
AMG 211 accumulation in CD3-rich tissues and clear, he-terogeneous tumor uptake
Clin Cancer Res. 2019;25:3517-27
111
Chapter 6 Development and evaluation of interleukin-2 derived
radiotracers for PET imaging of T-cells in mice
J Nucl Med. 2020;61:1355-466
135
Chapter 7 Radiolabeled monoclonal antibody against
colony-stimulating factor 1 receptor specifically distributes to spleen and liver in immunocompetent mice
Submitted
155
Chapter 8 Fluorescent image-guided surgery in breast cancer by
intravenous application of a quenched fluorescence probe for cysteine cathepsins in a syngeneic mouse model
EJNMMI Res. 2020;10:111
173
Chapter 9 Summary and future perspectives 191
Chapter 10 Nederlandse samenvatting (summary in Dutch) 201
