University of Groningen
Sleep as a synaptic architect
Raven, Frank
DOI:
10.33612/diss.131687500
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Publication date: 2020
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Citation for published version (APA):
Raven, F. (2020). Sleep as a synaptic architect: How sleep loss influences memory and synaptic plasticity. University of Groningen. https://doi.org/10.33612/diss.131687500
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SLEEP AS A SYNAPTIC ARCHITECT
HOW SLEEP LOSS INFLUENCES
MEMORY AND SYNAPTIC PLASTICITY
The work described in this thesis was performed within the Neurobiology expertise group at the Groningen Institute for Evolutionary Life Sciences (GELIFES), University of Groningen, Groningen, The Netherlands.
Printing of this thesis was supported by the Graduate School of Science and Engineering, University of Groningen, MBF Bioscience, and Noldus Informa-tion Technology.
ISBN: 978-94-034-2857-4 (printed version) ISBN: 978-94-034-2858-1 (electronic version)
Cover design: Salomons Design | www.salomonsdesign.myportfolio.com Lay-out: Publiss | www.publiss.nl
Printing: Ridderprint | www.ridderprint.nl Copyright © F. Raven, 2020.
All rights reserved. No part of this book may be reproduced, stored in a re-trieval system, or transmitted in any form or by any means, without prior writ-ten permission of the author.
Sleep as a Synaptic Architect
How sleep loss influences memory and synaptic plasticity
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op vrijdag 11 september 2020 om 16.15 uur
door
Frank Raven
geboren op 12 oktober 1991 te Sittard
Promotor
Prof. dr. E.A. van der Zee Copromotores Dr. R. Havekes Dr. P. Meerlo Beoordelingscommissie Prof. dr. M.J.H. Kas Prof. dr. J.H.H.J. Prickaerts Prof. dr. H.W.H.G. Kessels
Table of contents
Chapter 1
GENERAL INTRODUCTION
9
Chapter 2
THE ROLE OF SLEEP IN REGULATING STRUCTURAL PLASTICITY AND SYNAPTIC STRENGTH: IMPLICATIONS FOR MEMORY AND COGNITIVE FUNCTION
23
Chapter 3
A BRIEF PERIOD OF SLEEP DEPRIVATION CAUSES SPINE LOSS IN THE DENTATE GYRUS OF MICE
55
Chapter 4
SLEEP DEPRIVATION-INDUCED IMPAIRMENT OF MEMO-RY CONSOLIDATION IS NOT MEDIATED BY GLUCOCOR-TICOID STRESS HORMONES
85
Chapter 5
THE IMPACT OF COFILIN OVERACTIVATION ON HIP-POCAMPAL SHORT-TERM MEMORY FORMATION AND SYNAPTIC PLASTICITY
103
Chapter 6
ELUCIDATING THE ROLE OF PROTEIN SYNTHESIS IN HIPPOCAMPUS-DEPENDENT MEMORY CONSOLIDATION ACROSS THE DAY AND NIGHT
129
Chapter 7
GENERAL SUMMARY AND DISCUSSION
155
