University of Groningen
The role of troponin and albumin to assess myocardial dysfunction after cardiac surgery and
in the critically ill
van Beek, Dianne E.C.
DOI:
10.33612/diss.101333600
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Publication date:
2019
Link to publication in University of Groningen/UMCG research database
Citation for published version (APA):
van Beek, D. E. C. (2019). The role of troponin and albumin to assess myocardial dysfunction after cardiac
surgery and in the critically ill. Rijksuniversiteit Groningen. https://doi.org/10.33612/diss.101333600
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The role
of
troponin
and
albumin
to
assess myocardial dysfunction
after
cardiac surgery
and in
the critically ill
ISBN: 978-94-034-2065-3
Cover design and layout: © evelienjagtman.com printing: Ridderprint BV - www.ridderprint.nl
Printing of this thesis was financially supported by the University Medical Center Groningen © E.C. van Beek 2019
All rights are reserved. No part of this publication may be reproduced, stored, or transmitted in any form or by any means without permission of the copyright owners.
The role
of
troponin
and
albumin
to
assess myocardial dysfunction
after
cardiac surgery
and in
the critically ill
PROEFSCHRIFT
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. C. Wijmenga en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op Maandag 2 december 2019 om 16.15 uur
Door:
Egidia Christina van Beek
Promotores:
Prof. dr. T.W.L. Scheeren Prof. dr. M.M.R.F. Struys Prof. dr. J.C.C. van der Horst
Beoordelingscommissie:
Prof. dr. J.E. Tulleken Prof. dr. W.F. Buhre Prof. dr. M.L. Bots
Table of contents
1. General introduction 7
PART I Optimizing the use of troponin as a marker for excessive myocardial damage after cardiac surgery
2. Implementation of the third universal definition for myocardial
infarction after coronary artery bypass grafting in Western Europe 19 3. How typical is the typical rise and fall of troponin in (peri-procedural)
myocardial infarction 35
4. Improving the use of troponin to assess the risk for mortality after
cardiac surgery: a retrospective cohort study 57
PART II The role of albumin in myocardial dysfunction in the intensive care unit
5. Albumin, a marker for postoperative myocardial damage 75
6. Predictive value of serum albumin levels at ICU admission in a mixed ICU population on noradrenaline and fluid requirements in the first 24 hours
91
7. Low serum albumin and new-onset atrial fibrillation in the ICU:
a prospective cohort study 107
8. Validation of serum albumin as a prognostic marker in the intensive
care unit: a SICS-I sub-study 117
Appendix
9. Summary and general discussion 131
10. Acknowledgements | Dankwoord 145
