University of Groningen
Clinical and molecular phenotyping of asthma and COPD
Boudewijn, Ilse Maria
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Boudewijn, I. M. (2019). Clinical and molecular phenotyping of asthma and COPD. University of Groningen.
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Clinical
and
molecular
phenotyping
of
asthma
and
COPD
Boudewijn, Ilse Maria
Clinical and molecular phenotyping of asthma and COPD
PhD dissertation, University of Groningen, The Netherlands
ISBN 978-94-6375-069-1
ISBN (electronic) 978-94-6375-179-7
© Copyright 2019 – Ilse Boudewijn, Groningen, The Netherlands
All rights reserved. No part of this thesis may be reproduced, stored in a retrieval system or transmitted in any form or by any means, without prior permission of the author or, when appropriate, of the publisher of the publication or illustration material.
Cover design Evelien Jagtman | evelienjagtman.com
Lay-out Nikki Vermeulen | Ridderprint BV
Printing Ridderprint BV | www.ridderprint.nl
Printing of this thesis was financially supported by the University of Groningen, University Medical Center Groningen, Graduate School of Medical Sciences, GUIDE, department of pulmonary diseases UMCG, Longfonds, Stichting Astmabestrijding, ALK-Albello B.V., Boehringer Ingelheim B.V., Chiesi Pharmaceuticals B.V., Chipsoft B.V., Noord Negentig, Stethoscoopspecialist.nl and TEVA Netherlands B.V.
Clinical
and
molecular
phenotyping
of
asthma
and
COPD
Proefschrift
ter verkrijging van de graad van doctor aan de Rijksuniversiteit Groningen
op gezag van de
rector magnificus prof. dr. E. Sterken en volgens besluit van het College voor Promoties.
De openbare verdediging zal plaatsvinden op woensdag 27 maart 2019 om 14.30 uur
door
Ilse Maria Boudewijn
geboren op 19 mei 1987 te Groningen
Promotores
Prof. dr. D.S. Postma Prof. dr. V. Guryev
Copromotor
Dr. M. van den Berge
Beoordelingscommissie
Prof. dr. C.E. Brightling Prof. dr. G.G. Brusselle Prof. dr. R. Gosens
Paranimfen
Dr. E. Hartmans Drs. S. Lubberts
TABLE OF CONTENTS
Chapter 1 General introduction 7
PART 1 CLINICAL PHENOTYPING
Chapter 2 Less small airway dysfunction in asymptomatic bronchial 29 hyperresponsiveness than in asthma
Chapter 3 Effects of ageing and smoking on pulmonary computed 45 tomography scans using parametric response mapping
Chapter 4 Extrafine compared to non-extrafine particle inhaled 55 corticosteroids in smokers and ex-smokers with asthma
Chapter 5 Predictors of clinical response to extrafine and non-extrafine 73 particle inhaled corticosteroids in smokers and ex-smokers
with asthma
Chapter 6 Bronchial provocation testing can be improved by using 83 dry powder adenosine instead of nebulized adenosine
monophosphate
PART 2 MOLECULAR PHENOTYPING
Chapter 7 Nasal gene expression differentiates COPD from controls and 93 overlaps bronchial gene expression
Chapter 8 Nasal gene expression changes with inhaled corticosteroid 113 treatment in asthma
Chapter 9 A novel role of bronchial microRNAs and long non-coding RNAs 133 in asthma remission
Chapter 10 Summary 155 Chapter 11 General discussion and future perspectives 163
Chapter 12 Nederlandse samenvatting 183
