Citation
Haven, C. J. (2008, May 28). Molecular analysis of the HPJ-JT syndrome and sporadic parathyroid carcinogenesis. Retrieved from
https://hdl.handle.net/1887/12960
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License: Licence agreement concerning inclusion of doctoral thesis in the Institutional Repository of the University of Leiden
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Molecular analysis of
the HPT-JT syndrome and
sporadic parathyroid carcinogenesis
Molecular analysis of
the HPT-JT syndrome and
sporadic parathyroid carcinogenesis
Proefschrift
ter verkrijging van
de graad van Doctor aan de Universiteit Leiden,
op gezag van de Rector Magnificus prof.mr. P.F. van der Heijden, volgens besluit van het College voor Promoties
te verdedigen op woensdag 28 mei 2008 klokke 16.15 uur
door
Carola José Haven
geboren te Wolvega in 1971
Table of contents
Chapter 1 Introduction and outline 9-22 Chapter 2 A genotypic and histopathological study of a large Dutch kindred 23-30
with hyperparathyroidism-jaw tumor syndrome.
J Clin Endocrinol Metab. 2000 Apr;85(4):1449-54.
Chapter 3 HRPT2, encoding parafibromin, is mutated in hyper- 31-38 parathyroidism-jaw tumor syndrome.
Nat. Genet. 2002 Dec;32(4):676-80. Epub 2002 Nov 18.
Chapter 4 HRPT2 mutations are associated with malignancy in 39-48 sporadic parathyroid tumours.
J Med Genet. 2003 Sep;40(9):657-63.
Chapter 5 Loss of parafibromin immunoreactivity is a distinguishing feature 49-60 of parathyroid carcinoma.
Clin. Cancer Res. 2004 Oct 1;10(19):6629-37.
Chapter 6 Differential expression of the calcium sensing receptor and 61-72 combined loss of chromosomes 1q and 11q in parathyroid
carcinoma.
J Pathol. 2004 Jan;202(1):86-94.
Chapter 7 Identification of MEN1 and HRPT2 somatic mutations in paraffin- 73-82 embedded (sporadic) parathyroid carcinomas.
Clin Endocrinol (Oxf). 2007 Sep;67(3):370-6. Epub 2007 Jun 6.
Chapter 8 Gene expression of parathyroid tumors and identification of the 83-92 potential malignant phenotype.
J Med Genet. 2003 Sep;40(9):657-63.
Chapter 9 Multiplex ligation-dependent probe amplification analysis in 93-106 parathyroid tumours
manuscript
Chapter 10 Concluding remarks 107-114 Chapter 11 Summary/Samenvatting 115-124 Colour Figures 125-133 Curriculum Vitae 134 Thanks to 135
